We established a variety of cohorts to understand factors that impact ovulation and menstruation health across the lifespan and to fill the gap in scientific research in assessing menstrual irregularities. Our studies focus on factors that optimize health during reproductive transition such as pregnancy, birth, and menopause, as well as diseases including ovulatory disorders such as polycystic ovary syndrome (PCOS), infertility, endometriosis, and uterine fibroids.