Recent studies by the Rubin Lab reveal a genetic determinant of single-cell phenotypic heterogeneity, which may have implications for strategies to shorten the course of therapy. In this photo, a strain where this gene (lamA) has been deleted is shown alongside wild-type mycobacteria, after addition of the drug vancomycin. Green-fluorescent cells turn red upon cell death due to presence of propidium iodide, revealing the difference in survival of the strains in the face of drug treatment.
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