Irene Heinz Given Professor of Immunology and Infectious Diseases
665 Huntington Ave
HIM Building, RM 1048
Boston, MA 02115
Tuberculosis is the leading infectious killer of adults worldwide. As HIV predisposes to tuberculosis, the number of deaths has been rising rapidly in many parts of the world. Despite over a century of research on the causative organism, Mycobacterium tuberculosis, we still have a very poor understanding of tuberculous infections. Our goal is to better understand the basic biology of this pathogen and to develop new therapeutic strategies.
Our research focuses on three areas. We study the fundamental cell biology of the organisms, including central processes such as cell wall metabolism, cell growth and translation. We also investigate the interface between the host and pathogen, identifying factors provided by both that determine the outcome of infection. Finally, we are deeply involved in trying to change the process of antibiotic discovery using new approaches to finding antibacterial compounds and understanding their mechanisms of action. To accomplish all of these we use a variety of tools, many developed in our lab, to manipulate and study this important pathogen.
M.D., 1990, Tufts University School of Medicine
Ph.D., 1990, Sackler School of Biomedical Sciences, Tufts University