Greg works on improving and understanding macrophage restriction of Mycobacterium tuberculosis infection.
Michael is coordinating IMPAcTB, an international, multi-institution project that aims to identify and characterize mechanisms of host protection against tuberculosis across animal models and human patient cohorts.
Mike works with Bioinformatics, data munging, analysis of Next-Generation Sequence data, and proteomics data. Perl, R and shell scripting.
Peter researches high-throughput RNA-Sequencing of Mycobacterium tuberculosis strains across various growth conditions to link genotype to phenotypic variation.
Abigail is taking cues from Mycobacterium tuberculosis on what is important for its survival through studying genes under selection during infection. She is currently working towards understanding the effects of selection on a classic Mtb virulence system.
Patty is Postdoctoral Fellow who is working towards understanding the action of antibodies in natural TB infection. She is working to address whether human antibodies from different TB disease states can confer control of Mtb growth or protection in a mouse model of Mtb infection. Patty works in between the labs of Sarah Fortune at HSPH and Galit Alter at the Ragon Institute. Feature article, “Science in the A.L.P.S.,” about Patty’s experience…
Forrest defines the parameters that are expected to drive the rate of resistance observed clinically and establish a quantitative estimate of risk of the emergence of drug resistance in clinical use to Pretomanid and a larger panel of compounds in development.
Eddie is interested in the role antibodies play during tuberculosis infection. He is taking biased and unbiased approaches to identify specific characteristics of the humoral immune response capable of modulating infection or disease.
Wiktor’s research involves Fc glycosylation and how it impacts innate immune cell functionality.
Qingyun’s research interests center around employing population genomics approaches to comprehend the evolutionary mechanisms through which bacterial pathogens enhance their propagation within human host populations. Gaining insight into the successfully adapted bacterial variants could open new avenues for the design of precision target-based interventions.
Tetiana comes to HSPH with a background in medicinal chemistry and small molecules synthesis, working recently in a contract research organization on integrated projects for 9 years. Her passion is working on integrated projects combining synthetic chemistry, biology, and computational chemistry.
Maia is interested in understanding what good host protection against tuberculosis challenge looks like. She is currently working on defining the role of lung epithelial and stromal cells in immune cell circuits and crosstalk after vaccination or tuberculosis infection using single-cell RNA sequencing. Maia’s work is in collaboration with her co-mentor Adam Haber.
Byron is highly motivated to provide advanced technical assistance for animal studies involving human pathogens across several laboratories within the department.
Jake is an infectious disease physician at MGH and a postdoctoral fellow in the Fortune Lab studying how the immune response to tuberculosis can be harnessed to improve vaccines and therapies.
Jamie hopes to use his genetics training and varied lab experience to help the Fortune group to better understand the mechanisms behind Mtb infection and how these can be addressed.