Home People Publications Software Links	Welcome to Cheng Li’s Computational Genomics Research Group We develop analysis methods and software for high-throughput microarray and sequencing data, and apply these methods to cancer and neuroscience studies. Please see our research areas below (Contact us, Research positions). Integrative analysis of genomic alteration patterns in cancer, using SNP arrays, exon and gene expression arrays, and microRNA platforms (Li 09, Walker 06). SNP arrays are used to identify cancer genomic alterations such as LOH and copy number changes (Li 08, Beroukhim 06, Garraway 05, Zhao 04). Cross-species analysis of brain aging and Alzheimer's disease, using human, monkey, and mouse gene expression array data (Loerch 08, Lu 04). dChip software. We are dedicated to developing and maintaining the user-friendly and free microarray analysis software dChip (Manual, User group). (Li 08, Leykin 05). dChip provides many analysis and visualization methods for gene expression and SNP microarray data and has been used in many research applications. It is the first software to perform model-based analysis of oligonucleotide expression array data and one of the first to perform copy number and LOH analysis of SNP arrays. New analysis methods are constantly developed and tested in dChip through collaborative projects and then provided for broader use. Current research support: National Institutes of Health. Address Room 11036, Center for Life Sciences, 3 Blackfan Circle, Boston, MA 02115 Department of Biostatistics, Harvard School of Public Health Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute Contact Cheng Li: Email cli@hsph.harvard.edu, Phone 617-632-3498