Sena Bae

Integrated annotation prioritizes metabolites with bioactivity in inflammatory bowel disease.

Bhosle A, Bae S, Zhang Y, Chun E, Avila-Pacheco J, Geistlinger L, Pishchany G, Glickman JN, Michaud M, Waldron L, Clish CB, Xavier RJ, Vlamakis H, Franzosa EA, Garrett WS, Huttenhower C.

Mol Syst Biol. 2024 Apr. 20(4):338-361. PMID: 38467837

Engineered Escherichia coli for the in situ secretion of therapeutic nanobodies in the gut.

Lynch JP, González-Prieto C, Reeves AZ, Bae S, Powale U, Godbole NP, Tremblay JM, Schmidt FI, Ploegh HL, Kansra V, Glickman JN, Leong JM, Shoemaker CB, Garrett WS, Lesser CF.

Cell Host Microbe. 2023 04 12. 31(4):634-649.e8. PMID: 37003258

Gut microbial metabolism of 5-ASA diminishes its clinical efficacy in inflammatory bowel disease.

Mehta RS, Mayers JR, Zhang Y, Bhosle A, Glasser NR, Nguyen LH, Ma W, Bae S, Branck T, Song K, Sebastian L, Pacheco JA, Seo HS, Clish C, Dhe-Paganon S, Ananthakrishnan AN, Franzosa EA, Balskus EP, Chan AT, Huttenhower C.

Nat Med. 2023 03. 29(3):700-709. PMID: 36823301

Faecalibaculum rodentium remodels retinoic acid signaling to govern eosinophil-dependent intestinal epithelial homeostasis.

Cao YG, Bae S, Villarreal J, Moy M, Chun E, Michaud M, Lang JK, Glickman JN, Lobel L, Garrett WS.

Cell Host Microbe. 2022 09 14. 30(9):1295-1310.e8. PMID: 35985335

A biosynthetic pathway for the selective sulfonation of steroidal metabolites by human gut bacteria.

Yao L, D'Agostino GD, Park J, Hang S, Adhikari AA, Zhang Y, Li W, Avila-Pacheco J, Bae S, Clish CB, Franzosa EA, Huttenhower C, Huh JR, Devlin AS.

Nat Microbiol. 2022 09. 7(9):1404-1418. PMID: 35982310

Discovery of bioactive microbial gene products in inflammatory bowel disease.

Zhang Y, Bhosle A, Bae S, McIver LJ, Pishchany G, Accorsi EK, Thompson KN, Arze C, Wang Y, Subramanian A, Kearney SM, Pawluk A, Plichta DR, Rahnavard A, Shafquat A, Xavier RJ, Vlamakis H, Garrett WS, Krueger A, Huttenhower C, Franzosa EA.

Nature. 2022 06. 606(7915):754-760. PMID: 35614211

Human gut bacteria produce ??17-modulating bile acid metabolites.

Paik D, Yao L, Zhang Y, Bae S, D'Agostino GD, Zhang M, Kim E, Franzosa EA, Avila-Pacheco J, Bisanz JE, Rakowski CK, Vlamakis H, Xavier RJ, Turnbaugh PJ, Longman RS, Krout MR, Clish CB, Rastinejad F, Huttenhower C, Huh JR, Devlin AS.

Nature. 2022 03. 603(7903):907-912. PMID: 35296854

A bacterial bile acid metabolite modulates Treg activity through the nuclear hormone receptor NR4A1.

Li W, Hang S, Fang Y, Bae S, Zhang Y, Zhang M, Wang G, McCurry MD, Bae M, Paik D, Franzosa EA, Rastinejad F, Huttenhower C, Yao L, Devlin AS, Huh JR.

Cell Host Microbe. 2021 09 08. 29(9):1366-1377.e9. PMID: 34416161

Whole microbial community viability is not quantitatively reflected by propidium monoazide sequencing approach.

Wang Y, Yan Y, Thompson KN, Bae S, Accorsi EK, Zhang Y, Shen J, Vlamakis H, Hartmann EM, Huttenhower C.

Microbiome. 2021 01 21. 9(1):17. PMID: 33478576

Fusobacterium nucleatum drives a pro-inflammatory intestinal microenvironment through metabolite receptor-dependent modulation of IL-17 expression.

Brennan CA, Clay SL, Lavoie SL, Bae S, Lang JK, Fonseca-Pereira D, Rosinski KG, Ou N, Glickman JN, Garrett WS.

Gut Microbes. 2021 Jan-Dec. 13(1):1987780. PMID: 34781821