Current Position:
Assistant Professor 
at Harvard Medical School
Doctoral Student:
2005-2011
Education:
Ph.D., 2011, Harvard T.H. Chan School of Public Health, Biological Sciences in Public Health
B.S., 1997, Cornell University
Publications:
Ricoult SJ, Dibble CC, Asara JM, Manning BD. SREBP regulates the expression and metabolic functions of wild-type and oncogenic IDH1. Mol Cell Biol. 2016; 36(18):2384-95. PMID: 27354064
Menon S, Dibble CC, Talbott G, Hoxhaj G, Valvezan AJ, Takahashi H, Cantley LC, Manning BD. Spatial control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome. Cell. 2014; 156(4):771-85. PMID: 24529379
Dibble CC, Manning BD. Signal intergration by mTORC1 coordinates nutrient input with biosynthetic output. Nat Cell Biol. 2013; 15(6):555-64. PMID: 23728461
Dibble CC, Elis W, Menon S, Qin W, Klekota J, Asara JM, Finan PM, Kwiatkowski DJ, Murphy LO, Manning BD. TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1. Mol Cell. 2012; 47(4):535-46. PMID: 22795129
Tanaka K, Babic I, Nathanson D, Akhavan D, Guo D, Gini B, Dang J, Zhu S, Yang H, de Jesus J, Amzajerdi AN, Zhang Y, Dibble CC, Dan H, Rinkenbaugh A, Yong WH, Vinters HV, Gera JF, Cavenee WK, Cloughesy TF, Manning BD, Baldwin AS, Mischel PS. Oncogenic EGFR signaling activates an mTORC2-NF-κB pathway that promotes chemotherapy resistance. Cancer Discov. 2011; 1(6):524-38. PMID: 22145100
Dibble CC, Manning BD. A molecular link between Akt regulation and chemotherapeutic response. Cancer Cell. 2009; 16(3):178-80. PMID: 19732717
Dibble CC, Asara JM, and Manning BD. Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1. Mol Cell Biol. 2009; 29(21):5657-70. PMID: 19720745
Huang Y, Zhang J, McHenry KT, Kim MM, Zeng W, Lopez-Pajares V, Dibble CC, Mizgerd JP, Yuan ZM. Induction of cytoplasmic accumulation of p53: a mechanism for low levels of arsenic exposure to predispose cells for malignant transformation. Cancer Res. 2008; 68(22):9131-6. PMID: 19010883
Huang J, Dibble CC, Matsuzaki M, Manning BD. The TSC1-TSC2 complex is required for proper activation of mTOR complex 2. Mol Cell Biol. 2008; 28(12):4104-15. PMID: 18411301
Zhang HH, Lipovsky AI, Dibble CC, Sahin M, Manning BD. S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt. Mol Cell. 2006; 24(2):185-97. PMID: 17052453
Fan L, Pepicelli CV, Dibble CC, Catbagan W, Zarycki JL, Laciak R, Gipp J, Shaw A, Lamm ML, Munoz A, Lipinski R, Thrasher JB, Bushman W. Hedgehog signaling promotes prostate xenograft tumor growth. Endocrinology. 2004; 145(8):3961-70. PMID: 15132968