Professor of Molecular Metabolism
Director of BPH program
Harvard T.H. Chan School of Public Health
The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals.
Torrence ME, MacArthur MR, Hosios AM, Valvezan AJ, Asara JM, Mitchell JR, Manning BD.
Elife. 2021 Mar 01. 10. PMID: 33646118
Valvezan AJ, McNamara MC, Miller SK, Torrence ME, Asara JM, Henske EP, Manning BD.
JCI Insight. 2020 04 09. 5(7). PMID: 32271165
Hoxhaj G, Manning BD.
Nat Rev Cancer. 2020 02. 20(2):74-88. PMID: 31686003
Brown FD, Sen DR, LaFleur MW, Godec J, Lukacs-Kornek V, Schildberg FA, Kim HJ, Yates KB, Ricoult SJH, Bi K, Trombley JD, Kapoor VN, Stanley IA, Cremasco V, Danial NN, Manning BD, Sharpe AH, Haining WN, Turley SJ.
Nat Immunol. 2019 12. 20(12):1668-1680. PMID: 31636464
Author Correction: Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis.
Liu P, Gan W, Inuzuka H, Lazorchak AS, Gao D, Arojo O, Liu D, Wan L, Zhai B, Yu Y, Yuan M, Kim BM, Shaik S, Menon S, Gygi SP, Lee TH, Asara JM, Manning BD, Blenis J, Su B, Wei W.
Nat Cell Biol. 2019 05. 21(5):662-663. PMID: 30783264
Hoxhaj G, Ben-Sahra I, Lockwood SE, Timson RC, Byles V, Henning GT, Gao P, Selfors LM, Asara JM, Manning BD.
Science. 2019 03 08. 363(6431):1088-1092. PMID: 30846598
Valvezan AJ, Manning BD.
Nat Metab. 2019 03. 1(3):321-333. PMID: 32694720
Nature. 2019 02. 566(7743):187-188. PMID: 30737501
Ex vivo and in vivo stable isotope labelling of central carbon metabolism and related pathways with analysis by LC-MS/MS.
Yuan M, Kremer DM, Huang H, Breitkopf SB, Ben-Sahra I, Manning BD, Lyssiotis CA, Asara JM.
Nat Protoc. 2019 02. 14(2):313-330. PMID: 30683937
We cannot treat our way out of the rising trend in cancer cases. The only solution is a full-scale defense, so that nobody suffers the disease in the first place.
March 26, 2019—In a new Science paper, Brendan Manning, professor of genetics and complex diseases, and colleagues reveal how a previously understudied enzyme may help fuel the metabolism of cancer cells and contribute to the development of other…
December 8, 2017 – A research team at Harvard T.H. Chan School of Public Health has identified a key metabolic vulnerability in some types of tumor cells and discovered a way to exploit it by harnessing well-known immunosuppressant…
October 20, 2015 — It was announced this week that two faculty members from Harvard T.H. Chan School of Public Health—Xihong Lin and Brendan Manning—received prestigious National Cancer Institute Outstanding Investigator Awards (OIA). These multimillion-dollar seven-year awards, providing…
Findings by Harvard School of Public Health’s Brendan Manning, professor of genetics and complex diseases, are providing new insights into tuberous sclerosis complex (TSC) — a rare genetic disease that causes the widespread growth of benign tumors —…