Brendan Manning
Primary Faculty

Brendan Manning

Professor of Molecular Metabolism

Molecular Metabolism

Other Positions

Acting Chair, Department of Molecular Metabolism

Molecular Metabolism

Harvard T.H. Chan School of Public Health


Brendan D. Manning is a Professor in the Department of Molecular Metabolism at the Harvard T.H. Chan School of Public Health and the Department of Cell Biology at Harvard Medical School, and a Faculty Member of the Dana-Farber/Harvard Cancer Center. Dr. Manning received his B.S. from the University of Massachusetts, Amherst, and his Ph.D. from Yale University. During his time as a postdoctoral fellow in the laboratory of Lewis Cantley at Harvard Medical School, he discovered that the tuberous sclerosis complex (TSC) tumor suppressors serve as the molecular connection between the PI3K and mTOR pathways, thereby linking a signaling pathway activated in the majority of human cancers to a nutrient-sensing pathway that controls cell growth and metabolism. In 2004, he joined the faculty of the then newly established Department of Genetics and Complex Diseases at Harvard (renamed Molecular Metabolism in 2019) to continue research at the interface of cell signaling and metabolism. Research in the Manning laboratory is particularly focused on the regulation and function of the PI3K - mTOR signaling network in physiology and disease. Dr. Manning was an inaugural recipient of the National Cancer Institute’s Outstanding Investigator Award.

Research in the Manning lab is defining the molecular interface between cellular signaling networks and metabolic networks, as it relates to both normal physiology and diseases with metabolic dysregulation as a key feature, including cancer, diabetes, neurological disorders, and aging-related diseases. Research efforts are focused in part on defining the regulatory mechanisms and functions of a signaling network converging on the tuberous sclerosis complex (TSC) protein complex and the mammalian target of rapamycin (mTOR), which relay an array of extracellular and intracellular growth signals to control the balance between anabolic and catabolic metabolism in cells, tissues, and tumors.

BS, 1993
University of Massachusetts, Amherst, Massachusetts

PhD, 2000
Yale University, New Haven, Connecticut



A new route to control cell metabolism and growth

March 26, 2019—In a new Science paper, Brendan Manning, professor of genetics and complex diseases, and colleagues reveal how a previously understudied enzyme may help fuel the metabolism of cancer cells and contribute to the development of other…

Targeting tumor metabolic vulnerabilities

December 8, 2017 – A research team at Harvard T.H. Chan School of Public Health has identified a key metabolic vulnerability in some types of tumor cells and discovered a way to exploit it by harnessing well-known immunosuppressant…

Xihong Lin, Brendan Manning, Shuji Ogino receive prestigious NCI awards

October 20, 2015 — It was announced this week that two faculty members from Harvard T.H. Chan School of Public Health—Xihong Lin and Brendan Manning—received prestigious National Cancer Institute Outstanding Investigator Awards (OIA). These multimillion-dollar seven-year awards, providing…