Current Position:
Assistant Professor at Children’s Research Institute at UT Southwestern
Postdoctoral Fellow:
2013 – 2019
Education:
Ph.D., 2012, MRC-PPU, University of Dundee, Scotland, UK
B.S., 2008, Bogazici University, Istanbul, Turkey
Publications:
Byles V, Cormerais Y, Kalafut K, Barrera V, Hughes Hallett JE, Sui SH, Asara JM, Adams CM, Hoxhaj G, Ben-Sahra I, Manning BD. Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin. Mol Metab. 2021 Jul 23:101309. doi: 10.1016/j.molmet.2021.101309. Epub ahead of print. PMID: 34303878.
Hoxhaj G, Manning BD. The PI3K-AKT Network at the Interface of Oncogenic Signalling and Cancer Metabolism. Nat Rev Cancer. 2020 Feb;20(2):74-88. doi:10.1038/s41568-019-0216-7. PMID: 31686003
Hoxhaj G, Ben-Sahra I, Lockwood SE, Timson RC, Byles V, Henning GT, Gao P, Selfors LM, Asara JM, Manning BD. Direct stimulation of NADP+ synthesis through Akt-mediated phosphorylation of NAD kinase. Science. 2019 Mar 8;363(6431):1088-1092. doi: 10.1126/science.aau3903. PMID: 30846598
Hoxhaj G, Hughes-Hallett J, Timson RC, Ilagan E, Yuan M, Asara JM, Ben-Sahra I, Manning BD. The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels. Cell Rep. 2017; 21(5):1331-1346. PMID: 29091770
Howell JJ, Hellberg K, Turner M, Talbott G, Kolar MJ, Ross DS, Hoxhaj G, Saghatelian A, Shaw RJ, Manning BD. Metformin Inhibits Hepatic mTORC1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex. Cell Metab. 2017; 25(2):463-471. PMID: 28089566
Heintz C, Doktor TK, Lanjuin A, Escoubas CC, Zhang Y, Weir HJ, Dutta S, Silva-Garcia CG, Bruun GH, Morantte I, Hoxhaj G, Manning BD, Andersen BS, Mair WB. Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans. Nature. 2017; 541(7635):102-106. PMID: 27919065
Hoxhaj G, Caddye E, Najafov A, Houde VP, Johnson C, Dissanayake K, Toth R, Campbell DG, Prescott AR, MacKintosh C. The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids. Elife. 2016; 5. pii: e12278. PMID: 27244671
Ben-Sahra I*, Hoxhaj G*, Ricoult SJH, Asara JM, Manning BD. mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle. Science. 2016; 351(6274):728-33. PMID: 26912861. *Co-1st authors.
Menon S, Dibble CC, Talbott G, Hoxhaj G, Valvezan AJ, Takahashi H, Cantley LC, Manning BD. Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome. Cell. 2014; 156(4): 771-85. PMID: 24529379
Hoxhaj G, Najafov A, Toth R, Campbell DG, Prescott AR, MacKintosh C. ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase. J Cell Sci. 2012; 125(Pt 19):4662-75. PMID: 22797923
Najafov A, Seker T, Even I, Hoxhaj G, Selvi O, Ozel DE, Koman A, Birgül-İyison N. MENA is a transcriptional target of the Wnt/beta-catenin pathway. PLoS One. 2012; 7(5):e37013. PMID: 22615875
Kavak E, Najafov A, Ozturk N, Seker T, Cavusoglu K, Aslan T, Duru AD, Saygili T, Hoxhaj G, Hiz MC, Unal DO, Birgül-Iyison N, Ozturk M, Koman A. Analysis of the Wnt/B-catenin/TCF4 pathway using SAGE, genome-wide microarray and promoter analysis: Identification of BRI3 and HSF2 as novel targets. Cell Signal. 2010; 22(10):1523-35. PMID: 20538055
Jeong JY, Hoxhaj G, Socha AL, Sytkowski AJ, Feldman L. An erythropoietin autocrine/paracrine axis modulates the growth and survival of human prostate cancer cells. Mol Cancer Res. 2009; 7(7):1150-7. PMID: 19567780