Postdoctoral Fellow:
2023 –
Education:
Ph.D., 2022, New York University Grossman School of Medicine
M.S., 2016, New York University Grossman School of Medicine
B.S., 2011, University of California, Berkeley
Research Interests:
Generally, interested in understanding the fundamental mechanisms of modern human diseases. Specifically, interested in the role of metabolic homeostasis in the initiation and progression of diseases such as cancer and depression.
Publications:
Shin J*, Phelan PJ*, Gjoerup O, Bachovchin W, Bullock PA. Characterization of a single chain variable fragment of nivolumab that targets PD–1 and blocks PD–L1 binding. Protein Expr Purif. 2021;177:105766. Epub 20200925. doi: 10.1016/j.pep.2020.105766. PubMed PMID: 32987122; PMCID: PMC7518118.
Wu L, Hollinshead KER, Hao Y, Au C, Kroehling L, Ng C, Lin WY, Li D, Silva HM, Shin J, Lafaille JJ, Possemato R, Pacold ME, Papagiannakopoulos T, Kimmelman AC, Satija R, Littman DR. Niche–Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic Redundancy. Cell. 2020;182(3):641–54 e20. Epub 20200701. doi: 10.1016/j.cell.2020.06.014. PubMed PMID: 32615085; PMCID: PMC7556360
Minton DR*, Nam M*, McLaughlin DJ*, Shin J, Bayraktar EC, Alvarez SW, Sviderskiy VO, Papagiannakopoulos T, Sabatini DM, Birsoy K, Possemato R. Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl–tRNAs. Mol Cell. 2018;69(4):610–21 e5. doi: 10.1016/j.molcel.2018.01.024. PubMed PMID: 29452640; PMCID: PMC5819360.
Peterson JN, Lin B, Shin J, Phelan PJ, Tsichlis P, Schwob JE, Bullock PA. Replication of JC Virus DNA in the G144 Oligodendrocyte Cell Line Is Dependent Upon Akt. J Virol. 2017;91(20). Epub 20170927. doi: 10.1128/JVI.00735– 17. PubMed PMID: 28768870; PMCID: PMC5625518.
Grubman SA*, Shin J*, Phelan PJ, Gong A, Can H, Dilworth R, Kini SK, Gagnon D, Archambault J, Meinke G, Bohm A, Jefferson DM, Bullock PA. Isolation of a monoclonal antibody that recognizes the origin binding domain of JCV, but not SV40, large T–antigen. Virology. 2016;497:92–101. Epub 20160721. doi: 10.1016/j.virol.2016.07.006.
PubMed PMID: 27433780.
Meinke G, Phelan PJ, Shin J, Gagnon D, Archambault J, Bohm A, Bullock PA. Structural Based Analyses of the JC Virus T–Antigen F258L Mutant Provides Evidence for DNA Dependent Conformational Changes in the C–Termini of Polyomavirus Origin Binding Domains. PLoS Pathog. 2016;12(1):e1005362. Epub 20160106. doi: 10.1371/journal.ppat.1005362. PubMed PMID: 26735515; PMCID: PMC4703215.
Shin J, Phelan PJ, Chhum P, Bashkenova N, Yim S, Parker R, Gagnon D, Gjoerup O, Archambault J, Bullock PA. Analysis of JC virus DNA replication using a quantitative and high–throughput assay. Virology. 2014;468– 470:113–25. Epub 20140824. doi: 10.1016/j.virol.2014.07.042. PubMed PMID: 25155200; PMCID: PMC4658058.
Meinke G, Phelan PJ, Kalekar R, Shin J, Archambault J, Bohm A, Bullock PA. Insights into the initiation of JC virus DNA replication derived from the crystal structure of the T–antigen origin binding domain. PLoS Pathog. 2014;10(2):e1003966. Epub 20140220. doi: 10.1371/journal.ppat.1003966. PubMed PMID: 24586168; PMCID: PMC3930596.