Doctoral Student:
2019 –
Education:
B.S., 2015, University of Pittsburgh
Research Interest:
Krystle is interested in understanding how the mTOR signaling network is regulated by nutrient availability and dietary conditions, and how this impacts cellular and systemic metabolism in healthy organisms, as well as in metabolic disease and aging. I am also interested in dissecting the tissue-specific roles of mTOR signaling.
Publications:
Hosios AM, Wilkinson ME, McNamara MC, Kalafut KC, Torrence ME, Asara JM, Manning BD. mTORC1 regulates a lysosome-dependent adaptive shift in intracellular lipid species. Nat Metab. 2022 Dec;4(12):1792-1811. doi: 10.1038/s42255-022-00706-6. Epub 2022 Dec 19. PMID: 36536136; PMCID: PMC9799240.
Kalafut KC, Mitchell SJ, MacArthur MR, Mitchell JR. Short-Term Ketogenic Diet Induces a Molecular Response That Is Distinct From Dietary Protein Restriction. Front Nutr. 2022 Mar 30;9:839341. doi: 10.3389/fnut.2022.839341. PMID: 35433789; PMCID: PMC9005751.
Byles V, Cormerais Y, Kalafut K, Barrera V, Hughes Hallett JE, Sui SH, Asara JM, Adams CM, Hoxhaj G, Ben-Sahra I, Manning BD. Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin. Mol Metab. 2021 Jul 23:101309. doi: 10.1016/j.molmet.2021.101309. Epub ahead of print. PMID: 34303878.
Di Francesco A, Choi Y, Bernier M, Zhang Y, Diaz-Ruiz A, Aon MA, Kalafut K, Ehrlich MR, Murt K, Ali A, Pearson KJ, Levan S, Preston JD, Martin-Montalvo A, Martindale JL, Abdelmohsen K, Michel CR, Willmes DM, Henke C, Navas P, Villalba JM, Siegel D, Gorospe M, Fritz K, Biswal S, Ross D, de Cabo R. NQO1 protects obese mice through improvements in glucose and lipid metabolism. NPJ Aging Mech Dis. 2020;6(1):13. PMCID: PMC7678866.