Postdoctoral Fellow:
2020 –
Education:
B.S. Cell and Molecular Biology, 2013, University of Montpellier II
M.S, Bio-Medical Research, 2015, University of Montpellier II: Control of the cell fate -Cancer
Ph.D., 2019, University of Montpellier
Research Interest:
Madi is interested in how signaling processes can control metabolic pathways and particularly how cancer cells can regulate their metabolism through these molecular mechanisms.
Publications:
Cissé MY, Pyrdziak S, Firmin N, Gayte L, Heuillet M, Bellvert F, Fuentes M, Delpech H, Riscal R, Arena G, Chibon F, Le Gellec S, Maran-Gonzalez A, Chateau MC, Theillet C, Carrere S, Portais JC, Le Cam L, Linares LK. Targeting MDM2-dependent serine metabolism as a therapeutic strategy for liposarcoma. Sci Transl Med. 2020;12(547):eaay2163. doi:10.1126/scitranslmed.aay2163. PMID: 32522803
Heuillet M, Millard P, Cissé MY, Linares LK, Létisse F, Manié S, Le Cam L, Portais JC, Bellvert F. Simultaneous Measurement of Metabolite Concentration and Isotope Incorporation by Mass Spectrometry. Anal Chem. 2020;92(8):5890-5896. doi:10.1021/acs.analchem.9b05709. PMID: 32212637
Andrique C, Morardet L, Linares LK, Cissé MY, Merle C, Chibon F, Provot S, Haÿ E, Ea HK, Cohen-Solal M, Modrowski D. Calpain-6 controls the fate of sarcoma stem cells by promoting autophagy and preventing senescence. JCI Insight. 2018;3(17):e121225. Published 2018 Sep 6. doi:10.1172/jci.insight.121225. PMID: 30185659
Arena G, Cissé MY, Pyrdziak S, Chatre L, Riscal R, Fuentes M, Arnold JJ, Kastner M, Gayte L, Bertrand-Gaday C, Nay K, Angebault-Prouteau C, Murray K, Chabi B, Koechlin-Ramonatxo C, Orsetti B, Vincent C, Casas F, Marine JC, Etienne-Manneville S, Bernex F, Lombès A, Cameron CE, Dubouchaud H, Ricchetti M, Linares LK, Le Cam L. Mitochondrial MDM2 Regulates Respiratory Complex I Activity Independently of p53. Mol Cell. 2018;69(4):594-609.e8. doi:10.1016/j.molcel.2018.01.023. PMID: 29452639
Riscal R, Schrepfer E, Arena G, Cissé MY, Bellvert F, Heuillet M, Rambow F, Bonneil E, Sabourdy F, Vincent C, Ait-Arsa I, Levade T, Thibaut P, Marine JC, Portais JC, Sarry JE, Le Cam L, Linares LK. Chromatin-Bound MDM2 Regulates Serine Metabolism and Redox Homeostasis Independently of p53. Mol Cell. 2016;62(6):890-902. doi:10.1016/j.molcel.2016.04.033. PMID: 27264869
Patent :
EP17306681.2: Methods for the diagnosis and treatment of liposarcoma – 2017