Current Position:
Postdoctoral Fellow in the Jacks Lab at MIT
Doctoral Student:
2015 – 2021
Education:
Ph.D., 2021, Harvard T.H. Chan School of Public Health, Biological Sciences in Public Health
B.S., 2015, Massachusetts Institute of Technology
Publications:
Torrence ME, MacArthur MR, Hosios AM, Valvezan AJ, Asara JM, Mitchell JR, Manning BD. The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals. eLife. 2021 Mar 1;10:e63326. doi: 10.7554/eLife.63326. Epub ahead of print. PMID: 33646118.
Valvezan AJ, McNamara MC, Miller SK, Torrence ME, Asara JM, Henske EP, Manning BD. IMPDH inhibitors for antitumor therapy in tuberous sclerosis complex. JCI Insight. 2020;5(7):e135071. Published 2020 Apr 9. doi:10.1172/jci.insight.135071. PMID: 32271165
Torrence ME and Manning BD. Nutrient Sensing in Cancer. Annu Rev Cancer Biol. 2018; 2:251-69. https://www.annualreviews.org/doi/full/10.1146/annurev-cancerbio-030617-050329
Kelsey I, Zbinden M, Byles V, Torrence M, Manning BD. mTORC1 suppresses PIM3 expression via miR-33 encoded by the SREBP loci. Sci Rep. 2017 Nov 23;7(1):16112. PMID: 29170467
Olivares O, Mayers JR, Gouirand V, Torrence ME, Gicquel T, Borge L, Lac S, Roques J, Lavaut MN, Berthezène P, Rubis M, Secq V, Garcia S, Moutardier V, Lombardo D, Iovanna JL, Tomasini R, Guillaumond F, Vander Heiden MG, Vasseur S. Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions. Nat Commun. 2017; 8:16031. PMID: 28685754
Mayers JR*, Torrence ME*, Danai LV, Papagiannakopoulos T, Davidson SM, Bauer MR, Lau AN, Ji BW, Dixit PD, Hosios AM, Muir A, Chin CR, Freinkman E, Jacks T, Wolpin BM, Vitkup D, Vander Heiden MG. Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers. Science. 2016; 353(6304):1161-5. PMID: 27609895. *Co-1st authors.
Yuan C, Clish CB, Wu C, Mayers JR, Kraft P, Townsend MK, Zhang M, Tworoger SS, Bao Y, Qian ZR, Rubinson DA, Ng K, Giovannucci EL, Ogino S, Stampfer MJ, Gaziano JM, Ma J, Sesso HD, Anderson GL, Cochrane BB, Manson JE, Torrence ME, Kimmelman AC, Amundadottir LT, Vander Heiden MG, Fuchs CS, Wolpin BM. Circulating Metabolites and Survival Among Patients with Pancreatic Cancer. J Natl Cancer Inst. 2016; 108(6):djv409. PMID: 26755275
Mayers JR, Wu C, Clish CB, Kraft P, Torrence ME, Fiske BP, Yuan C, Bao Y, Townsend MK, Tworoger SS, Davidson SM, Papagiannakopoulos T, Yang A, Dayton TL, Ogino S, Stampfer MJ, Giovannucci EL, Qian ZR, Rubinson DA, Ma J, Sesso HD, Gaziano JM, Cochrane BB, Liu S, Wactawski-Wende J, Manson JE, Pollak MN, Kimmelman AC, Souza A, Pierce K, Wang TJ, Gerszten RE, Fuchs CS, Vander Heiden MG, Wolpin BM. Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development. Nat Med. 2014; 20(10):1193-8. PMID: 25261994