Postdoctoral Fellow:
2017 – 2022
Education:
Ph.D., 2016, Charité Berlin (Germany)
M.Sc., 2011, Charité Berlin (Germany)
B.Sc., 2009, University of Bremen (Germany) and University of Glasgow (UK)
Research Interest:
Sandra is interested in understanding PI3K-Akt-TSC1/2-mTOR signaling in neurons. She is focused on identifying neurodevelopmental and metabolic defects caused by aberrant signaling of this pathway.
Publications:
Schrötter S, Yuskaitis CJ, MacArthur MR, Mitchell SJ, Hosios AM, Osipovich M, Torrence ME, Mitchell JR, Hoxhaj G, Sahin M, Manning BD. The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth. Cell Rep. 2022 May 17;39(7):110824. doi: 10.1016/j.celrep.2022.110824. PMID: 35584673; PMCID: PMC9175135
Brosig A, Fuchs J, Ipek F, Kroon C, Schrötter S, Vadhvani M, Polyzou A, Ledderose J, van Diepen M, Holzhütter HG, Trimbuch T, Gimber N, Schmoranzer J, Lieberam I, Rosenmund C, Spahn C, Scheerer P, Szczepek M, Leondaritis G, Eickholt BJ. The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches. Cell Rep. 2019;29(7):2028-2040.e8. doi:10.1016/j.celrep.2019.10.039. PMID: 31722215
Suckau O, Gross I, Schrötter S, Yang F, Luo J, Wree A, Chun J, Baska D, Baumgart J, Kano K, Aoki J, Bräuer AU. LPA1 , LPA2 , LPA4 , and LPA6 receptor expression during mouse brain development. Dev Dyn. 2019;248(5):375-395. doi:10.1002/dvdy.23. PMID:30847983
Cormerais Y, Pagnuzzi-Boncompagni M, Schrötter S, Giuliano S, Tambutté E, Endou H, Wempe MF, Pagès G, Pouysségur J, Picco V. Inhibition of the amino-acid transporter LAT1 demonstrates anti-neoplastic activity in medulloblastoma. J Cell Mol Med. 2019;23(4):2711-2718. doi:10.1111/jcmm.14176. PMID:30784173
Pelz C, Häckel S, Semini G, Schrötter S, Bintig W, Stricker S, Mrawietz G, Klein A, Lucka L, Shmanai V, Eickholt B, Hildmann A, Danker K. Inositol-C2-PAF acts as a biological response modifier and antagonizes cancer-relevant processes in mammary carcinoma cells. Cell Oncol (Dordr). 2018 Oct;41(5):505-516. Epub 2018 Jul 25. PMID:30047091
Schrötter S, Leondaritis G, Eickholt BJ. (2016). Capillary isoelectric focusing of Akt isoforms identifies highly dynamic phosphorylation in neuronal cells and brain tissue. J Biol Chem. 2016; 291(19): 10239–10251. PMID: 26945062
Hu H, Matter ML, Issa-Jahns L, Jijiwa M, Kraemer N, Musante L, de la Vega M, Ninnemann O, Schindler D, Damatova N, Eirich K, Sifringer M, Schrötter S, Eickholt BJ, van den Heuvel L, Casamina C, Stoltenburg-Didinger G, Ropers HH, Wienker TF, Hübner C, Kaindl AM. (2014). Mutations in PTRH2 cause novel infantile-onset multisystem disease with intellectual disability, microcephaly, progressive ataxia, and muscle weakness. Ann Clin Transl Neurol. 2014; 1(12):1024–1035. PMID: 25574476