Current Position:
Manager at Simon-Kucher & Partners
Doctoral Student:
2010 – 2016
Education:
Ph.D., 2016, Harvard T.H. Chan School of Public Health, Biological Sciences in Public Health
B.S., 2010, Massachusetts Institute of Technology, Cambridge, MA
Publications:
Brown FD, Sen DR, LaFleur MW, Godec J, Lukacs-Kornek V, Schildberg FA, Kim HJ, Yates KB, Ricoult SJH, Bi K, Trombley JD, Kapoor VN, Stanley IA, Cremasco V, Danial NN, Manning BD, Sharpe AH, Haining WN, Turley SJ. Fibroblastic reticular cells enhance T cell metabolism and survival via epigenetic remodeling. Nat Immunol. 2019;20(12):1668‐1680. doi:10.1038/s41590-019-0515-x. PMID: 31636464
Breitkopf SB, Ricoult SJH, Yuan M, Xu Y, Peake DA, Manning BD, Asara JM. A relative quantitative positive/negative ion switching method for untargeted lipidomics via high resolution LC-MS/MS from any biological source. Metabolomics. 2017; 13(3). pii: 30. PMID: 28496395
Ricoult SJ, Dibble CC, Asara JM, Manning BD. SREBP regulates the expression and metabolic functions of wild-type and onogenic IDH1. Mol Cell Biol. 2016; 36(18):2384-95. PMID: 27354064
Ricoult SJ, Yecies JL, Ben-Sahra I, Manning BD. Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP. Oncogene. 2016; 35(10):1250-60. PMID: 26028026
Ben-Sahra I*, Hoxhaj G*, Ricoult SJH, Asara JM, Manning BD. mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle. Science. 2016; 351(6274):728-33. PMID: 26912861. *Co-1st authors.
Priolo C, Ricoult SJ, Khabibullin D, Filippakis H, Yu J, Manning BD, Clish C, Henske EP. Tuberous Sclerosis Complex 2 Loss Increases Lysophosphatidylcholine Synthesis in Lymphangioleiomyomatosis. Am J Respir Cell Mol Biol. 2015; 53(1):33-41. PMID: 25780943
Zhang Y, Nicholatos J, Dreier JR, Ricoult SJ, Widenmaier SB, Hotamisligil GS, Kwiatkowski DJ, Manning BD. Coordinated regulation of protein synthesis and degradation by mTORC1. Nature. 2014; 513(7518):440-3. PMID: 25043031
Howell JJ, Ricoult SJ, Ben-Sahra I, Manning BD. A growing role for mTOR in promoting anabolic metabolism. Biochem Soc Trans. 2013; 41(4):906-12. PMID: 23863154
Ricoult SJ, Manning BD. The multifaceted role of mTORC1 in the control of lipid metabolism. EMBO Rep. 2013; 14(3):242-51. PMID: 23399656
Bell EL, Emerling BM, Ricoult SJ, Guarente L. SirT3 suppresses hypoxia inducible factor 1a and tumor growth by inhibiting mitochondrial ROS production. Oncogene. 2011; 30(26):2986-96. PMID: 21358671