Current Position:
Associate Scientist at Agios Pharmaceuticals
Doctoral Student:
2013 – 2020
Education:
Ph.D., 2020, Harvard T.H. Chan School of Public Health, Biological Sciences in Public Health
M.A., 2013, Nutrition and Metabolism, Boston University School of Medicine
B.S., 2008, Human Physiology, Boston University
Publications:
Byles V, Cormerais Y, Kalafut K, Barrera V, Hughes Hallett JE, Sui SH, Asara JM, Adams CM, Hoxhaj G, Ben-Sahra I, Manning BD. Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin. Mol Metab. 2021 Jul 23:101309. doi: 10.1016/j.molmet.2021.101309. Epub ahead of print. PMID: 34303878.
Hoxhaj G, Ben-Sahra I, Lockwood SE, Timson RC, Byles V, Henning GT, Gao P, Selfors LM, Asara JM, Manning BD. Direct stimulation of NADP+ synthesis through Akt-mediated phosphorylation of NAD kinase. Science. 2019 Mar 8;363(6431):1088-1092. doi: 10.1126/science.aau3903. PMID: 30846598
Kelsey I, Zbinden M, Byles V, Torrence M, Manning BD. mTORC1 suppresses PIM3 expression via miR-33 encoded by the SREBP loci. Sci Rep. 2017 Nov 23;7(1):16112. PMID: 29170467
Covarrubias AJ, Aksoylar HI, Yu J, Snyder NW, Worth AJ, Iyer SS, Wang J, Ben-Sahra I, Byles V, Polynne-Stapornkul T, Espinosa EC, Lamming D, Manning BD, Zhang Y, Blair IA, Horng T. Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation. Elife. 2016; 5. pii: e11612. PMID: 26894960
Byles V, Covarrubias A, Ben-Sahra I, Lamming, DW, Sabatini DM, Manning BD, Horng T. The TSC-mTOR Pathway Regulates Macrophage Polarization. Nature Communications. 2013; 4:2834. PMID: 24280772
Covarrubias A, Byles V, Horng T. ROS Sets the Stage for Macrophage Differentiation. Cell Research. 2013; 8:984-5. PMID: 23835480
Lovaas JD, Zhu L, Chiao CY, Byles V, Faller DV, Dai Y. SIRT1 Enhances Matrix Metalloproteinase-2 Expression and Tumor Cell Invasion in Prostate Cancer Cells. Prostate. 2013; 73(5):522-530. PMID: 23038275
Murakami T, Ockinger J, Yu J, Byles V, McColl A, Hofer A, Horng T. Critical Role for Calcium Mobilization in Activation of the Nlrp3 Inflammasome. Proc Natl Acad Sci USA. 2012; 109(28):11282-7. PMID: 22733741
Byles V, Zhu L, Lovaas JD, Chmilewski LK, Wang J, Faller DV, Dai Y. SIRT1 Induces EMT by Cooperating with EMT Inducing Transcription Factors and Enhances Prostate Cancer Migration and Metastasis. Oncogene. 2012; 31:4619-4629. PMID: 22249256
Byles V, Chmilewski LK, Wang J, Zhu L, Forman L, Faller DV, Dai Y. Aberrant Cytoplasmic Localization and Protein Stability of SIRT1 is Regulated by PI3K/IGF-1R Signaling in Human Cancer Cells. International Journal of Biological Sciences. 2010; 6:599-612. PMID: 20941378