Current Position:
Senior Scientist, AbbVie
Postdoctoral Fellow:
2010 – 2015
Education:
Ph.D. 2009 – University of Toronto, Canada
M.S. 2000 – Institute of Biophysics of Chinese Academy of Sciences, China
B.S. 1997 – Nankai University, China
Research Interests:
Cancer cells are dramatically different from normal cells in their metabolic functions. Yinan’s research aims at identifying metabolic and stress response pathways that provide the most attractive intervention points for treating cancer. Armed with such knowledge, he is trying to target these pathways by screening chemical compounds in search of new classes of cancer therapeutics.
Publications:
Zabala-Letona A, Arruabarrena-Aristorena A, Martín-Martín N, Fernandez-Ruiz S, Sutherland JD, Clasquin M, Tomas-Cortazar J, Jimenez J, Torres I, Quang P, Ximenez-Embun P, Bago R, Ugalde-Olano A, Loizaga-Iriarte A, Lacasa-Viscasillas I, Unda M, Torrano V, Cabrera D, van Liempd SM, Cendon Y, Castro E, Murray S, Revandkar A, Alimonti A, Zhang Y, Barnett A, Lein G, Pirman D, Cortazar AR, Arreal L, Prudkin L, Astobiza I, Valcarcel-Jimenez L, Zuñiga-García P, Fernandez-Dominguez I, Piva M, Caro-Maldonado A, Sánchez-Mosquera P, Castillo-Martín M, Serra V, Beraza N, Gentilella A, Thomas G, Azkargorta M, Elortza F, Farràs R, Olmos D, Efeyan A, Anguita J, Muñoz J, Falcón-Pérez JM, Barrio R, Macarulla T, Mato JM, Martinez-Chantar ML, Cordon-Cardo C, Aransay AM, Marks K, Baselga J, Tabernero J, Nuciforo P, Manning BD, Marjon K, Carracedo A. mTORC1-dependent AMD1 regulation sustrains polyamine metabolism in prostate cancer. Nature. 2017; 547(7661):109-113. PMID:28658205
Zhang Y, Nicholatos J, Dreier JR, Ricoult SJ, Widenmaier SB, Hotamisligil GS, Kwiatkowski DJ, Manning BD. Coordinated regulation of protein synthesis and degradation by mTORC1. Nature. 2014; 513(7518):440-3. PMID: 25043031
Tanaka K, Babic I, Nathanson D, Akhavan D, Guo D, Gini B, Dang J, Zhu S, Yang H, de Jesus J, Amzajerdi AN, Zhang Y, Dibble CC, Dan H, Rinkenbaugh A, Yong WH, Vinters HV, Gera JF, Cavenee WK, Cloughesy TF, Manning BD, Baldwin AS, Mischel PS. Oncogenic EGFR signaling activates an mTORC2-NF-kB pathway that promotes chemotherapy resistance. Cancer Discov. 2011; 1(6):524-538. PMID: 22145100
Zhang Y, Kozlov G, Pocanschi C, Brockmeier U, Ireland BS, Maattanen P, Howe C, Elliott T, Gehring K, Williams DB. ERp57 does not require interactions with calnexin and calreticulin to promote assembly of class I histocompatibility molecules and it enhances peptide loading independently of its redox activity. J Biol Chem. 2009; 284(15):10160-73. PMID: 19196713
Zhang Y, Williams DB. Assembly of MHC class I molecules within the endoplasmic reticulum. Immunol Res. 2006; 35(1-2):151-62. PMID: 17003517
Zhang Y, Baig E, Williams DB. Functions of ERp57 in the folding and assembly of major histocompatibility complex class I molecules. J Biol Chem. 2006; 281(21):14622-31. PMID: 16567808
Hu K, Sun Y, Chen D, Zhang Y. The effect of lipid environment in purple membrane on bacteriorhodopsin. J Photochem Photobiol B. 2000; 58(2-3):163-9. PMID: 11233645
Zhang Y, Yang G, Hu K. The conformational and functional effect of biotin modification on purple membrane. ACTA Biophysica Sinica. 2000; 16(4):797-800.