Alan Cowman

Development and application of a high-throughput screening assay for identification of small molecule inhibitors of the P. falciparum reticulocyte binding-like homologue 5 protein.

Sleebs BE, Jarman KE, Frolich S, Wong W, Healer J, Dai W, Lucet IS, Wilson DW, Cowman AF.

Int J Parasitol Drugs Drug Resist. 2020 12. 14:188-200. PMID: 33152623

Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway.

LaMonte GM, Rocamora F, Marapana DS, Gnädig NF, Ottilie S, Luth MR, Worgall TS, Goldgof GM, Mohunlal R, Santha Kumar TR, Thompson JK, Vigil E, Yang J, Hutson D, Johnson T, Huang J, Williams RM, Zou BY, Cheung AL, Kumar P, Egan TJ, Lee MCS, Siegel D, Cowman AF, Fidock DA, Winzeler EA.

Nat Commun. 2020 04 14. 11(1):1780. PMID: 32286267

Dual Plasmepsin-Targeting Antimalarial Agents Disrupt Multiple Stages of the Malaria Parasite Life Cycle.

Favuzza P, de Lera Ruiz M, Thompson JK, Triglia T, Ngo A, Steel RWJ, Vavrek M, Christensen J, Healer J, Boyce C, Guo Z, Hu M, Khan T, Murgolo N, Zhao L, Penington JS, Reaksudsan K, Jarman K, Dietrich MH, Richardson L, Guo KY, Lopaticki S, Tham WH, Rottmann M, Papenfuss T, Robbins JA, Boddey JA, Sleebs BE, Sabroux HJ, McCauley JA, Olsen DB, Cowman AF.

Cell Host Microbe. 2020 04 08. 27(4):642-658.e12. PMID: 32109369

Uncovering the ART of antimalarial resistance.

Marapana D, Cowman AF.

Science. 2020 01 03. 367(6473):22-23. PMID: 31896702

Inhibition of Plasmepsin V Activity Blocks Plasmodium falciparum Gametocytogenesis and Transmission to Mosquitoes.

Jennison C, Lucantoni L, O'Neill MT, McConville R, Erickson SM, Cowman AF, Sleebs BE, Avery VM, Boddey JA.

Cell Rep. 2019 12 17. 29(12):3796-3806.e4. PMID: 31851913

The Metabolite Repair Enzyme Phosphoglycolate Phosphatase Regulates Central Carbon Metabolism and Fosmidomycin Sensitivity in Plasmodium falciparum.

Dumont L, Richardson MB, van der Peet P, Marapana DS, Triglia T, Dixon MWA, Cowman AF, Williams SJ, Tilley L, McConville MJ, Cobbold SA.

mBio. 2019 12 10. 10(6). PMID: 31822583

Protein Kinase A Is Essential for Invasion of Plasmodium falciparum into Human Erythrocytes.

Wilde ML, Triglia T, Marapana D, Thompson JK, Kouzmitchev AA, Bullen HE, Gilson PR, Cowman AF, Tonkin CJ.

mBio. 2019 10 08. 10(5). PMID: 31594816

A 4-cyano-3-methylisoquinoline inhibitor of Plasmodium falciparum growth targets the sodium efflux pump PfATP4.

Gilson PR, Kumarasingha R, Thompson J, Zhang X, Penington JS, Kalhor R, Bullen HE, Lehane AM, Dans MG, de Koning-Ward TF, Holien JK, Soares da Costa TP, Hulett MD, Buskes MJ, Crabb BS, Kirk K, Papenfuss AT, Cowman AF, Abbott BM.

Sci Rep. 2019 07 16. 9(1):10292. PMID: 31311978

Neutralising antibodies block the function of Rh5/Ripr/CyRPA complex during invasion of Plasmodium falciparum into human erythrocytes.

Healer J, Wong W, Thompson JK, He W, Birkinshaw RW, Miura K, Long CA, Soroka V, Søgaard TMM, Jørgensen T, de Jongh WA, Weir C, Svahn E, Czabotar PE, Tham WH, Mueller I, Barlow PN, Cowman AF.

Cell Microbiol. 2019 07. 21(7):e13030. PMID: 30965383

Guided STED nanoscopy enables super-resolution imaging of blood stage malaria parasites.

Schloetel JG, Heine J, Cowman AF, Pasternak M.

Sci Rep. 2019 03 18. 9(1):4674. PMID: 30886187