Alan Cowman

Optimisation of 2-(N-phenyl carboxamide) triazolopyrimidine antimalarials with moderate to slow acting erythrocytic stage activity.

Bailey BL, Nguyen W, Ngo A, Goodman CD, Gancheva MR, Favuzza P, Sanz LM, Gamo FJ, Lowes KN, McFadden GI, Wilson DW, Laleu B, Brand S, Jackson PF, Cowman AF, Sleebs BE.

Bioorg Chem. 2021 Oct. 115:105244. PMID: 34452759

High-dimensional mass cytometry identifies T cell and B cell signatures predicting reduced risk of Plasmodium vivax malaria.

Ioannidis LJ, Pietrzak HM, Ly A, Utami RA, Eriksson EM, Studniberg SI, Abeysekera W, Li-Wai-Suen CS, Sheerin D, Healer J, Puspitasari AM, Apriyanti D, Coutrier FN, Poespoprodjo JR, Kenangalem E, Andries B, Prayoga P, Sariyanti N, Smyth GK, Trianty L, Cowman AF, Price RN, Noviyanti R, Hansen DS.

JCI Insight. 2021 Jul 22. 6(14). PMID: 34128836

4D analysis of malaria parasite invasion offers insights into erythrocyte membrane remodeling and parasitophorous vacuole formation.

Geoghegan ND, Evelyn C, Whitehead LW, Pasternak M, McDonald P, Triglia T, Marapana DS, Kempe D, Thompson JK, Mlodzianoski MJ, Healer J, Biro M, Cowman AF, Rogers KL.

Nat Commun. 2021 06 15. 12(1):3620. PMID: 34131147

Development and application of a high-throughput screening assay for identification of small molecule inhibitors of the P. falciparum reticulocyte binding-like homologue 5 protein.

Sleebs BE, Jarman KE, Frolich S, Wong W, Healer J, Dai W, Lucet IS, Wilson DW, Cowman AF.

Int J Parasitol Drugs Drug Resist. 2020 12. 14:188-200. PMID: 33152623

Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway.

LaMonte GM, Rocamora F, Marapana DS, Gnädig NF, Ottilie S, Luth MR, Worgall TS, Goldgof GM, Mohunlal R, Santha Kumar TR, Thompson JK, Vigil E, Yang J, Hutson D, Johnson T, Huang J, Williams RM, Zou BY, Cheung AL, Kumar P, Egan TJ, Lee MCS, Siegel D, Cowman AF, Fidock DA, Winzeler EA.

Nat Commun. 2020 04 14. 11(1):1780. PMID: 32286267

Dual Plasmepsin-Targeting Antimalarial Agents Disrupt Multiple Stages of the Malaria Parasite Life Cycle.

Favuzza P, de Lera Ruiz M, Thompson JK, Triglia T, Ngo A, Steel RWJ, Vavrek M, Christensen J, Healer J, Boyce C, Guo Z, Hu M, Khan T, Murgolo N, Zhao L, Penington JS, Reaksudsan K, Jarman K, Dietrich MH, Richardson L, Guo KY, Lopaticki S, Tham WH, Rottmann M, Papenfuss T, Robbins JA, Boddey JA, Sleebs BE, Sabroux HJ, McCauley JA, Olsen DB, Cowman AF.

Cell Host Microbe. 2020 04 08. 27(4):642-658.e12. PMID: 32109369

Uncovering the ART of antimalarial resistance.

Marapana D, Cowman AF.

Science. 2020 01 03. 367(6473):22-23. PMID: 31896702

Inhibition of Plasmepsin V Activity Blocks Plasmodium falciparum Gametocytogenesis and Transmission to Mosquitoes.

Jennison C, Lucantoni L, O'Neill MT, McConville R, Erickson SM, Cowman AF, Sleebs BE, Avery VM, Boddey JA.

Cell Rep. 2019 12 17. 29(12):3796-3806.e4. PMID: 31851913

The Metabolite Repair Enzyme Phosphoglycolate Phosphatase Regulates Central Carbon Metabolism and Fosmidomycin Sensitivity in Plasmodium falciparum.

Dumont L, Richardson MB, van der Peet P, Marapana DS, Triglia T, Dixon MWA, Cowman AF, Williams SJ, Tilley L, McConville MJ, Cobbold SA.

mBio. 2019 12 10. 10(6). PMID: 31822583

Protein Kinase A Is Essential for Invasion of Plasmodium falciparum into Human Erythrocytes.

Wilde ML, Triglia T, Marapana D, Thompson JK, Kouzmitchev AA, Bullen HE, Gilson PR, Cowman AF, Tonkin CJ.

mBio. 2019 10 08. 10(5). PMID: 31594816