Neuronal mTORC1 inhibition promotes longevity without suppressing anabolic growth and reproduction in C. elegans
Hannah J Smith, Anne Lanjuin, Arpit Sharma, Aditi Prabhakar, Emina Tabakovic, Rohan Sehgal, William B Mair.
bioRxiv. 2021.
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Metabolic Communication and Healthy Aging: Where Should We Focus Our Energy?
Smith HJ, Sharma A, Mair WB.
Dev Cell. 2020 07 20. 54(2):196-211. PMID: 32619405
Impact of short- and long-term electrically induced muscle exercise on gene signaling pathways, gene expression, and PGC1a methylation in men with spinal cord injury.
Petrie MA, Sharma A, Taylor EB, Suneja M, Shields RK.
Physiol Genomics. 2020 02 01. 52(2):71-80. PMID: 31869286
Causal roles of mitochondrial dynamics in longevity and healthy aging.
Sharma A, Smith HJ, Yao P, Mair WB.
EMBO Rep. 2019 12 05. 20(12):e48395. PMID: 31667999
Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis.
Tompkins SC, Sheldon RD, Rauckhorst AJ, Noterman MF, Solst SR, Buchanan JL, Mapuskar KA, Pewa AD, Gray LR, Oonthonpan L, Sharma A, Scerbo DA, Dupuy AJ, Spitz DR, Taylor EB.
Cell Rep. 2019 09 03. 28(10):2608-2619.e6. PMID: 31484072
Impaired skeletal muscle mitochondrial pyruvate uptake rewires glucose metabolism to drive whole-body leanness.
Sharma A, Oonthonpan L, Sheldon RD, Rauckhorst AJ, Zhu Z, Tompkins SC, Cho K, Grzesik WJ, Gray LR, Scerbo DA, Pewa AD, Cushing EM, Dyle MC, Cox JE, Adams C, Davies BS, Shields RK, Norris AW, Patti G, Zingman LV, Taylor EB.
Elife. 2019 07 18. 8. PMID: 31305240
Oxaloacetic acid mediates ADP-dependent inhibition of mitochondrial complex II-driven respiration.
Fink BD, Bai F, Yu L, Sheldon RD, Sharma A, Taylor EB, Sivitz WI.
J Biol Chem. 2018 12 21. 293(51):19932-19941. PMID: 30385511
The role of the skeletal muscle mitochondrial pyruvate carrier in systemic glucose homeostasis and whole-body adiposity
Arpit Sharma.
The role of the skeletal muscle mitochondrial pyruvate carrier in systemic glucose homeostasis and whole-body adiposity. 2018.
Distinct Skeletal Muscle Gene Regulation from Active Contraction, Passive Vibration, and Whole Body Heat Stress in Humans.
Petrie MA, Kimball AL, McHenry CL, Suneja M, Yen CL, Sharma A, Shields RK.
PLoS One. 2016. 11(8):e0160594. PMID: 27486743