Arpit Sharma

The CRTC-1 transcriptional domain is required for COMPASS complex-mediated longevity in C. elegans.

Silva-García CG, Láscarez-Lagunas LI, Papsdorf K, Heintz C, Prabhakar A, Morrow CS, Pajuelo Torres L, Sharma A, Liu J, Colaiácovo MP, Brunet A, Mair WB.

Nat Aging. 2023 Nov. 3(11):1358-1371. PMID: 37946042

Neuronal mTORC1 inhibition promotes longevity without suppressing anabolic growth and reproduction in C. elegans.

Smith HJ, Lanjuin A, Sharma A, Prabhakar A, Nowak E, Stine PG, Sehgal R, Stojanovski K, Towbin BD, Mair WB.

PLoS Genet. 2023 Sep. 19(9):e1010938. PMID: 37721956

Efficacy of longevity interventions in C. elegans is determined by early life activity of RNA splicing factors

Sneha Dutta, Caroline Heintz, Maria C. Perez-Matos, Ayse Sena Mutlu, Mary E. Piper, Meeta Mistry, Arpit Sharma, Hannah J. Smith, Porsha Howell, Rohan Sehgal, Anne Lanjuin, Meng C. Wang, William B. Mair.

2021.

Neuronal mTORC1 inhibition promotes longevity without suppressing anabolic growth and reproduction in C. elegans

Hannah J Smith, Anne Lanjuin, Arpit Sharma, Aditi Prabhakar, Emina Tabakovic, Rohan Sehgal, William B Mair.

bioRxiv. 2021.

Metabolic Communication and Healthy Aging: Where Should We Focus Our Energy?

Smith HJ, Sharma A, Mair WB.

Dev Cell. 2020 07 20. 54(2):196-211. PMID: 32619405

Finding community during a pandemic.

Sharma A.

Science. 2020 Apr 10. 368(6487):206. PMID: 32273472

Impact of short- and long-term electrically induced muscle exercise on gene signaling pathways, gene expression, and PGC1a methylation in men with spinal cord injury.

Petrie MA, Sharma A, Taylor EB, Suneja M, Shields RK.

Physiol Genomics. 2020 02 01. 52(2):71-80. PMID: 31869286

Causal roles of mitochondrial dynamics in longevity and healthy aging.

Sharma A, Smith HJ, Yao P, Mair WB.

EMBO Rep. 2019 12 05. 20(12):e48395. PMID: 31667999

Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis.

Tompkins SC, Sheldon RD, Rauckhorst AJ, Noterman MF, Solst SR, Buchanan JL, Mapuskar KA, Pewa AD, Gray LR, Oonthonpan L, Sharma A, Scerbo DA, Dupuy AJ, Spitz DR, Taylor EB.

Cell Rep. 2019 09 03. 28(10):2608-2619.e6. PMID: 31484072

Impaired skeletal muscle mitochondrial pyruvate uptake rewires glucose metabolism to drive whole-body leanness.

Sharma A, Oonthonpan L, Sheldon RD, Rauckhorst AJ, Zhu Z, Tompkins SC, Cho K, Grzesik WJ, Gray LR, Scerbo DA, Pewa AD, Cushing EM, Dyle MC, Cox JE, Adams C, Davies BS, Shields RK, Norris AW, Patti G, Zingman LV, Taylor EB.

Elife. 2019 07 18. 8. PMID: 31305240