Switching an active site helix in dihydrofolate reductase reveals limits to subdomain modularity.
Zhao VY, Rodrigues JV, Lozovsky ER, Hartl DL, Shakhnovich EI.
Biophys J. 2021 Sep 25. PMID: 34571014
Other Academic
Daniel L. Hartl
Professor in the Department of Immunology and Infectious Diseases
Immunology and Infectious Diseases
Links
Bibliography
Genetic surveillance for monitoring the impact of drug use on Plasmodium falciparum populations.
Ndiaye YD, Hartl DL, McGregor D, Badiane A, Fall FB, Daniels RF, Wirth DF, Ndiaye D, Volkman SK.
Int J Parasitol Drugs Drug Resist. 2021 Jul 26. 17:12-22. PMID: 34333350
Fine-scale variation in malaria prevalence across ecological regions in Madagascar: a cross-sectional study.
Rice BL, Golden CD, Randriamady HJ, Rakotomalala AANA, Vonona MA, Anjaranirina EJG, Hazen J, Castro MC, Metcalf CJE, Hartl DL.
BMC Public Health. 2021 05 29. 21(1):1018. PMID: 34051786
Relevance of Higher-Order Epistasis in Drug Resistance.
Lozovsky ER, Daniels RF, Heffernan GD, Jacobus DP, Hartl DL.
Mol Biol Evol. 2021 01 04. 38(1):142-151. PMID: 32745183
Genetic background and PfKelch13 affect artemisinin susceptibility of PfCoronin mutants in Plasmodium falciparum.
Sharma AI, Shin SH, Bopp S, Volkman SK, Hartl DL, Wirth DF.
PLoS Genet. 2020 12. 16(12):e1009266. PMID: 33370279
Study Protocol: A Cross-Sectional Examination of Socio-Demographic and Ecological Determinants of Nutrition and Disease Across Madagascar.
Golden CD, Rice BL, Randriamady HJ, Vonona AM, Randrianasolo JF, Tafangy AN, Andrianantenaina MY, Arisco NJ, Emile GN, Lainandrasana F, Mahonjolaza RFF, Raelson HP, Rakotoarilalao VR, Rakotomalala AANA, Rasamison AD, Mahery R, Tantely ML, Girod R, Annapragada A, Wesolowski A, Winter A, Hartl DL, Hazen J, Metcalf CJE.
Front Public Health. 2020. 8:500. PMID: 33042943
Genetic evidence for imported malaria and local transmission in Richard Toll, Senegal.
Daniels RF, Schaffner SF, Dieye Y, Dieng G, Hainsworth M, Fall FB, Diouf CN, Ndiop M, Cisse M, Gueye AB, Sarr O, Guinot P, Deme AB, Bei AK, Sy M, Thwing J, MacInnis B, Earle D, Guinovart C, Sene D, Hartl DL, Ndiaye D, Steketee RW, Wirth DF, Volkman SK.
Malar J. 2020 Aug 03. 19(1):276. PMID: 32746830
Evidence for Reduced Malaria Parasite Population after Application of Population-Level Antimalarial Drug Strategies in Southern Province, Zambia.
Daniels RF, Schaffner SF, Bennett A, Porter TR, Yukich JO, Mulube C, Mambwe B, Mwenda MC, Chishimba S, Bridges DJ, Moonga H, Hamainza B, Chizema Kawesha E, Miller JM, Steketee RW, Wirth DF, Eisele TP, Hartl DL, Volkman SK.
Am J Trop Med Hyg. 2020 08. 103(2_Suppl):66-73. PMID: 32618255
Experimental evolution for niche breadth in bacteriophage T4 highlights the importance of structural genes.
Pham JY, Ogbunugafor CB, Nguyen Ba AN, Hartl DL.
Microbiologyopen. 2020 02. 9(2):e968. PMID: 31778298
Limits to Compensatory Mutations: Insights from Temperature-Sensitive Alleles.
Tomala K, Zrebiec P, Hartl DL.
Mol Biol Evol. 2019 09 01. 36(9):1874-1883. PMID: 31058959
News
Malaria genetic surveillance project receives HGI grant
A Harvard T.H. Chan School of Public Health project to conduct genetic surveillance of malaria parasites in China is one of seven projects to receive grants this year from the Harvard Global Institute (HGI). Led by Dyann Wirth,…
Using genomics to shed light on malaria transmission
May 13, 2015 — To fight malaria, it’s crucial to assess the effectiveness of interventions against the mosquito-borne disease. But when malaria transmission declines, traditional methods for estimating transmission—based on mosquito sampling—become difficult. Now, a new study from Harvard…
