Erik James Hasenoehrl

An amiloride derivative is active against the F1Fo-ATP synthase and cytochrome bd oxidase of Mycobacterium tuberculosis.

Hards K, Cheung CY, Waller N, Adolph C, Keighley L, Tee ZS, Harold LK, Menorca A, Bujaroski RS, Buckley BJ, Tyndall JDA, McNeil MB, Rhee KY, Opel-Reading HK, Krause K, Preiss L, Langer JD, Meier T, Hasenoehrl EJ, Berney M, Kelso MJ, Cook GM.

Commun Biol. 2022 02 24. 5(1):166. PMID: 35210534

Bioenergetic Inhibitors: Antibiotic Efficacy and Mechanisms of Action in Mycobacterium tuberculosis.

Hasenoehrl EJ, Wiggins TJ, Berney M.

Front Cell Infect Microbiol. 2020. 10:611683. PMID: 33505923

Dual inhibition of the terminal oxidases eradicates antibiotic-tolerant Mycobacterium tuberculosis.

Lee BS, Hards K, Engelhart CA, Hasenoehrl EJ, Kalia NP, Mackenzie JS, Sviriaeva E, Chong SMS, Manimekalai MSS, Koh VH, Chan J, Xu J, Alonso S, Miller MJ, Steyn AJC, Grüber G, Schnappinger D, Berney M, Cook GM, Moraski GC, Pethe K.

EMBO Mol Med. 2021 01 11. 13(1):e13207. PMID: 33283973

Derailing the aspartate pathway of Mycobacterium tuberculosis to eradicate persistent infection.

Hasenoehrl EJ, Rae Sajorda D, Berney-Meyer L, Johnson S, Tufariello JM, Fuhrer T, Cook GM, Jacobs WR, Berney M.

Nat Commun. 2019 09 16. 10(1):4215. PMID: 31527595

Inhibitors of energy metabolism interfere with antibiotic-induced death in mycobacteria.

Lee BS, Kalia NP, Jin XEF, Hasenoehrl EJ, Berney M, Pethe K.

J Biol Chem. 2019 02 08. 294(6):1936-1943. PMID: 30530783

Exploiting the synthetic lethality between terminal respiratory oxidases to kill Mycobacterium tuberculosis and clear host infection.

Kalia NP, Hasenoehrl EJ, Ab Rahman NB, Koh VH, Ang MLT, Sajorda DR, Hards K, Grüber G, Alonso S, Cook GM, Berney M, Pethe K.

Proc Natl Acad Sci U S A. 2017 07 11. 114(28):7426-7431. PMID: 28652330

Oxidative Phosphorylation as a Target Space for Tuberculosis: Success, Caution, and Future Directions.

Cook GM, Hards K, Dunn E, Heikal A, Nakatani Y, Greening C, Crick DC, Fontes FL, Pethe K, Hasenoehrl E, Berney M.

Microbiol Spectr. 2017 06. 5(3). PMID: 28597820