Variant-specific Mendelian Risk Prediction Model.
Bae E, Dias JA, Huang T, Chen J, Parmigiani G, Rebbeck TR, Braun D.
bioRxiv. 2023 Mar 08. PMID: 36945459
Primary Faculty
Giovanni Parmigiani
Other Positions
Professor of Biostatistics, Harvard T.H. Chan School of Public Health
Freshman Seminar -Other Academic
Harvard Faculty of Arts and Sciences
Professor of Biostatistics, Harvard T.H. Chan School of Public Health
Freshman Seminar -Other Academic
Harvard Faculty of Arts and Sciences
Overview
Models and software for predicting who is at risk of carrying genetic variants that confer susceptibility to cancer. Application to breast, ovarian, colorectal, pancreatic and skin cancer.
Statistical methods for the analysis of high throughput genomic data: analysis of cancer genome sequencing projects; integration of genomic information across technologies; cross-study validation of genomics results.
Statistical methods for comparative effectiveness research: comprehensive models for lifetime history of chronic disease outcomes; Bayesian meta-analysis; Bayesian causal inference; decision analysis.
Bayesian modeling and computation: multilevel models; decision theoretic approaches to inference; sequential experimental design and their application to adaptive and multistage studies in clinical and epidemiological research.
Bibliography
Combining Breast Cancer Risk Prediction Models.
Guan Z, Huang T, McCarthy AM, Hughes K, Semine A, Uno H, Trippa L, Parmigiani G, Braun D.
Cancers (Basel). 2023 Feb 08. 15(4). PMID: 36831433
MyLynch: A Patient-Facing Clinical Decision Support Tool for Genetically-Guided Personalized Medicine in Lynch Syndrome.
Knapp ST, Revette A, Underhill-Blazey M, Stopfer JE, Ukaegbu CI, Poulin C, Parenteau M, Syngal S, Bae E, Bickmore T, Hampel H, Idos GE, Parmigiani G, Yurgelun MB, Braun D.
Cancers (Basel). 2023 Jan 06. 15(2). PMID: 36672340
High-Dose Melphalan Treatment Significantly Increases Mutational Burden at Relapse in Multiple Myeloma.
Samur MK, Roncador M, Aktas Samur A, Fulciniti M, Bazarbachi AH, Szalat RE, Shammas MA, Sperling AS, Richardson PG, Magrangeas F, Minvielle S, Perrot A, Corre J, Moreau P, Thakurta A, Parmigiani G, Anderson KC, Avet-Loiseau H, Munshi NC.
Blood. 2023 Jan 05. PMID: 36603186
In-depth analysis of alternative splicing landscape in multiple myeloma and potential role of dysregulated splicing factors.
Aktas Samur A, Fulciniti M, Avet-Loiseau H, Lopez MA, Derebail S, Corre J, Minvielle S, Magrangeas F, Moreau P, Anderson KC, Parmigiani G, Samur MK, Munshi NC.
Blood Cancer J. 2022 12 20. 12(12):171. PMID: 36535935
Loss of ribonuclease DIS3 hampers genome integrity in myeloma by disrupting DNA:RNA hybrid metabolism.
Gritti I, Basso V, Rinchai D, Corigliano F, Pivetti S, Gaviraghi M, Rosano D, Mazza D, Barozzi S, Roncador M, Parmigiani G, Legube G, Parazzoli D, Cittaro D, Bedognetti D, Mondino A, Segalla S, Tonon G.
EMBO J. 2022 11 17. 41(22):e108040. PMID: 36215697
Hierarchical resampling for bagging in multistudy prediction with applications to human neurochemical sensing.
Loewinger G, Patil P, Kishida KT, Parmigiani G.
Ann Appl Stat. 2022 Dec. 16(4):2145-2165. PMID: 36274786
A validation of models for prediction of pathogenic variants in mismatch repair genes.
Shyr C, Blackford AL, Huang T, Ke J, Ouardaoui N, Trippa L, Syngal S, Ukaegbu C, Uno H, Nafa K, Stadler ZK, Offit K, Amos CI, Lynch PM, Chen S, Giardiello FM, Buchanan DD, Hopper JL, Jenkins MA, Southey MC, Win AK, Figueiredo JC, Braun D, Parmigiani G.
Genet Med. 2022 10. 24(10):2155-2166. PMID: 35997715
Validity and Relative Validity of Alternative Methods of Assessing Physical Activity in Epidemiologic Studies: Findings From the Men's Lifestyle Validation Study.
Pernar CH, Chomistek AK, Barnett JB, Ivey K, Al-Shaar L, Roberts SB, Rood J, Fielding RA, Block J, Li R, Willett WC, Parmigiani G, Giovannucci EL, Mucci LA, Rimm EB.
Am J Epidemiol. 2022 06 27. 191(7):1307-1322. PMID: 35292800
Statistical methods for Mendelian models with multiple genes and cancers.
Liang JW, Idos GE, Hong C, Gruber SB, Parmigiani G, Braun D.
Genet Epidemiol. 2022 10. 46(7):395-414. PMID: 35583099
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