Bayesian combinatorial MultiStudy factor analysis.
Grabski IN, Vito R, Trippa L, Parmigiani G.
Ann Appl Stat. 2023 Sep. 17(3):2212-2235. PMID: 37786772
Primary Faculty
Giovanni Parmigiani
Other Positions
Professor of Biostatistics, Harvard T.H. Chan School of Public Health
First Year Seminar Program
Harvard Faculty of Arts and Sciences
Overview
Models and software for predicting who is at risk of carrying genetic variants that confer susceptibility to cancer. Application to breast, ovarian, colorectal, pancreatic and skin cancer.
Statistical methods for the analysis of high throughput genomic data: analysis of cancer genome sequencing projects; integration of genomic information across technologies; cross-study validation of genomics results.
Statistical methods for comparative effectiveness research: comprehensive models for lifetime history of chronic disease outcomes; Bayesian meta-analysis; Bayesian causal inference; decision analysis.
Bayesian modeling and computation: multilevel models; decision theoretic approaches to inference; sequential experimental design and their application to adaptive and multistage studies in clinical and epidemiological research.
Bibliography
Meta-Analysis of Breast Cancer Risk for Individuals with PALB2 Pathogenic Variants.
Ruberu TLM, Braun D, Parmigiani G, Biswas S.
medRxiv. 2023 Jun 04. PMID: 37398422
Clinical implications of conflicting variant interpretations in the cancer genetics clinic.
Zukin E, Culver JO, Liu Y, Yang Y, Ricker CN, Hodan R, Sturgeon D, Kingham K, Chun NM, Rowe-Teeter C, Singh K, Zell JA, Ladabaum U, McDonnell KJ, Ford JM, Parmigiani G, Braun D, Kurian AW, Gruber SB, Idos GE.
Genet Med. 2023 Jul. 25(7):100837. PMID: 37057674
High-dose melphalan treatment significantly increases mutational burden at relapse in multiple myeloma.
Samur MK, Roncador M, Aktas Samur A, Fulciniti M, Bazarbachi AH, Szalat R, Shammas MA, Sperling AS, Richardson PG, Magrangeas F, Minvielle S, Perrot A, Corre J, Moreau P, Thakurta A, Parmigiani G, Anderson KC, Avet-Loiseau H, Munshi NC.
Blood. 2023 04 06. 141(14):1724-1736. PMID: 36603186
Variant-specific Mendelian Risk Prediction Model.
Bae E, Dias JA, Huang T, Chen J, Parmigiani G, Rebbeck TR, Braun D.
bioRxiv. 2023 Mar 08. PMID: 36945459
Combining Breast Cancer Risk Prediction Models.
Guan Z, Huang T, McCarthy AM, Hughes K, Semine A, Uno H, Trippa L, Parmigiani G, Braun D.
Cancers (Basel). 2023 Feb 08. 15(4). PMID: 36831433
Cross-Study Replicability in Cluster Analysis.
Masoero L, Thomas E, Parmigiani G, Tyekucheva S, Trippa L.
Stat Sci. 2023 May. 38(2):303-316. PMID: 37885824
MyLynch: A Patient-Facing Clinical Decision Support Tool for Genetically-Guided Personalized Medicine in Lynch Syndrome.
Knapp ST, Revette A, Underhill-Blazey M, Stopfer JE, Ukaegbu CI, Poulin C, Parenteau M, Syngal S, Bae E, Bickmore T, Hampel H, Idos GE, Parmigiani G, Yurgelun MB, Braun D.
Cancers (Basel). 2023 Jan 06. 15(2). PMID: 36672340
In-depth analysis of alternative splicing landscape in multiple myeloma and potential role of dysregulated splicing factors.
Aktas Samur A, Fulciniti M, Avet-Loiseau H, Lopez MA, Derebail S, Corre J, Minvielle S, Magrangeas F, Moreau P, Anderson KC, Parmigiani G, Samur MK, Munshi NC.
Blood Cancer J. 2022 12 20. 12(12):171. PMID: 36535935
Loss of ribonuclease DIS3 hampers genome integrity in myeloma by disrupting DNA:RNA hybrid metabolism.
Gritti I, Basso V, Rinchai D, Corigliano F, Pivetti S, Gaviraghi M, Rosano D, Mazza D, Barozzi S, Roncador M, Parmigiani G, Legube G, Parazzoli D, Cittaro D, Bedognetti D, Mondino A, Segalla S, Tonon G.
EMBO J. 2022 Nov 17. 41(22):e108040. PMID: 36215697
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Prominent bioinformatics expert to join Harvard School of Public Health faculty and become chair of Dana-Farber Department of Biostatistics and Computational Biology
For immediate release: July 9, 2009 Boston, MA -- Giovanni Parmigiani, PhD, a noted leader in applying bioinformatics tools to cancer studies and medical decision-making, has been appointed professor of biostatistics at Harvard School of Public Health (HSPH)…