Gregory Hunter Babunovic

A terpene nucleoside from M. tuberculosis induces lysosomal lipid storage in foamy macrophages.

Bedard M, van der Niet S, Bernard EM, Babunovic G, Cheng TY, Aylan B, Grootemaat AE, Raman S, Botella L, Ishikawa E, O'Sullivan MP, O'Leary S, Mayfield JA, Buter J, Minnaard AJ, Fortune SM, Murphy LO, Ory DS, Keane J, Yamasaki S, Gutierrez MG, van der Wel N, Moody DB.

J Clin Invest. 2023 03 15. 133(6). PMID: 36757797

A MAPS Vaccine Induces Multipronged Systemic and Tissue-Resident Cellular Responses and Protects Mice against Mycobacterium tuberculosis.

O'Hara JM, Wakabayashi S, Siddiqi N, Cheung E, Babunovic GH, Thompson CM, Lu YJ, Rubin EJ, Malley R, Zhang F.

mBio. 2023 02 28. 14(1):e0361122. PMID: 36749098

Tuberculosis treatment failure associated with evolution of antibiotic resilience.

Liu Q, Zhu J, Dulberger CL, Stanley S, Wilson S, Chung ES, Wang X, Culviner P, Liu YJ, Hicks ND, Babunovic GH, Giffen SR, Aldridge BB, Garner EC, Rubin EJ, Chao MC, Fortune SM.

Science. 2022 12 09. 378(6624):1111-1118. PMID: 36480634

CRISPR Interference Reveals That All-Trans-Retinoic Acid Promotes Macrophage Control of Mycobacterium tuberculosis by Limiting Bacterial Access to Cholesterol and Propionyl Coenzyme A.

Babunovic GH, DeJesus MA, Bosch B, Chase MR, Barbier T, Dickey AK, Bryson BD, Rock JM, Fortune SM.

mBio. 2022 02 22. 13(1):e0368321. PMID: 35038923

High-Throughput CRISPR Screens To Dissect Macrophage-Shigella Interactions.

Lai Y, Cui L, Babunovic GH, Fortune SM, Doench JG, Lu TK.

mBio. 2021 12 21. 12(6):e0215821. PMID: 34933448

Illuminating Host-Mycobacterial Interactions with Genome-wide CRISPR Knockout and CRISPRi Screens.

Lai Y, Babunovic GH, Cui L, Dedon PC, Doench JG, Fortune SM, Lu TK.

Cell Syst. 2020 09 23. 11(3):239-251.e7. PMID: 32970993

Heterogeneous GM-CSF signaling in macrophages is associated with control of Mycobacterium tuberculosis.

Bryson BD, Rosebrock TR, Tafesse FG, Itoh CY, Nibasumba A, Babunovic GH, Corleis B, Martin C, Keegan C, Andrade P, Realegeno S, Kwon D, Modlin RL, Fortune SM.

Nat Commun. 2019 05 27. 10(1):2329. PMID: 31133636

Mycobacterium tuberculosis-specific CD4+ and CD8+ T cells differ in their capacity to recognize infected macrophages.

Yang JD, Mott D, Sutiwisesak R, Lu YJ, Raso F, Stowell B, Babunovic GH, Lee J, Carpenter SM, Way SS, Fortune SM, Behar SM.

PLoS Pathog. 2018 02. 14(5):e1007060. PMID: 29782535

Posttranslational modification of a histone-like protein regulates phenotypic resistance to isoniazid in mycobacteria.

Sakatos A, Babunovic GH, Chase MR, Dills A, Leszyk J, Rosebrock T, Bryson B, Fortune SM.

Sci Adv. 2018 05. 4(5):eaao1478. PMID: 29732401