Gunes Parlakgul

Ubiquinone deficiency drives reverse electron transport to disrupt hepatic metabolic homeostasis in obesity.

Goncalves RLS, Wang ZB, Inouye KE, Lee GY, Fu X, Saksi J, Rosique C, Parlakgul G, Arruda AP, Hui ST, Loperena MC, Burgess SC, Graupera I, Hotamisligil GS.

bioRxiv. 2023 Feb 22. PMID: 36865319

Endoplasmic Reticulum Architecture and Inter-Organelle Communication in Metabolic Health and Disease.

Arruda AP, Parlakgül G.

Cold Spring Harb Perspect Biol. 2023 02 01. 15(2). PMID: 35940911

Integration of ER protein quality control mechanisms defines ß cell function and ER architecture.

Shrestha N, Torres M, Zhang J, Lu Y, Haataja L, Reinert RB, Knupp J, Chen YJ, Parlakgul G, Arruda AP, Tsai B, Arvan P, Qi L.

J Clin Invest. 2023 01 03. 133(1). PMID: 36346671

Regulation of liver subcellular architecture controls metabolic homeostasis.

Parlakgül G, Arruda AP, Pang S, Cagampan E, Min N, Güney E, Lee GY, Inouye K, Hess HF, Xu CS, Hotamisligil GS.

Nature. 2022 03. 603(7902):736-742. PMID: 35264794

Aberrant Ca2+ signaling by IP3Rs in adipocytes links inflammation to metabolic dysregulation in obesity.

Guney E, Arruda AP, Parlakgul G, Cagampan E, Min N, Lee GY, Greene L, Tsaousidou E, Inouye K, Han MS, Davis RJ, Hotamisligil GS.

Sci Signal. 2021 Dec 14. 14(713):eabf2059. PMID: 34905386

Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity.

Bartelt A, Widenmaier SB, Schlein C, Johann K, Goncalves RLS, Eguchi K, Fischer AW, Parlakgül G, Snyder NA, Nguyen TB, Bruns OT, Franke D, Bawendi MG, Lynes MD, Leiria LO, Tseng YH, Inouye KE, Arruda AP, Hotamisligil GS.

Nat Med. 2018 03. 24(3):292-303. PMID: 29400713

Defective STIM-mediated store operated Ca2+ entry in hepatocytes leads to metabolic dysfunction in obesity.

Arruda AP, Pers BM, Parlakgul G, Güney E, Goh T, Cagampan E, Lee GY, Goncalves RL, Hotamisligil GS.

Elife. 2017 12 15. 6. PMID: 29243589

Type I Interferons Interfere with Liver Glucose Metabolism.

Parlakgul G, Hotamisligil GS.

Cell Metab. 2017 06 06. 25(6):1211-1212. PMID: 28591628

A 3 Year-Old Male Child Ingested Approximately 750 Grams of Elemental Mercury.

Uysalol M, Parlakgül G, Yilmaz Y, Çitak A, Uzel N.

Balkan Med J. 2016 Jul. 33(4):467-9. PMID: 27606146

Chronic enrichment of hepatic endoplasmic reticulum-mitochondria contact leads to mitochondrial dysfunction in obesity.

Arruda AP, Pers BM, Parlakgül G, Güney E, Inouye K, Hotamisligil GS.

Nat Med. 2014 Dec. 20(12):1427-35. PMID: 25419710