Gurol Tuncman

Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism.

Tirosh A, Tuncman G, Calay ES, Rathaus M, Ron I, Tirosh A, Yalcin A, Lee YG, Livne R, Ron S, Minsky N, Arruda AP, Hotamisligil GS.

Cell Metab. 2021 Feb 02. 33(2):319-333.e6. PMID: 33340456

The short-chain fatty acid propionate increases glucagon and FABP4 production, impairing insulin action in mice and humans.

Tirosh A, Calay ES, Tuncman G, Claiborn KC, Inouye KE, Eguchi K, Alcala M, Rathaus M, Hollander KS, Ron I, Livne R, Heianza Y, Qi L, Shai I, Garg R, Hotamisligil GS.

Sci Transl Med. 2019 04 24. 11(489). PMID: 31019023

Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes.

Burak MF, Inouye KE, White A, Lee A, Tuncman G, Calay ES, Sekiya M, Tirosh A, Eguchi K, Birrane G, Lightwood D, Howells L, Odede G, Hailu H, West S, Garlish R, Neale H, Doyle C, Moore A, Hotamisligil GS.

Sci Transl Med. 2015 Dec 23. 7(319):319ra205. PMID: 26702093

Adipocyte lipid chaperone AP2 is a secreted adipokine regulating hepatic glucose production.

Cao H, Sekiya M, Ertunc ME, Burak MF, Mayers JR, White A, Inouye K, Rickey LM, Ercal BC, Furuhashi M, Tuncman G, Hotamisligil GS.

Cell Metab. 2013 May 07. 17(5):768-78. PMID: 23663740

Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis.

Nakamura T, Furuhashi M, Li P, Cao H, Tuncman G, Sonenberg N, Gorgun CZ, Hotamisligil GS.

Cell. 2010 Feb 05. 140(3):338-48. PMID: 20144759

Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice.

Furuhashi M, Fucho R, Görgün CZ, Tuncman G, Cao H, Hotamisligil GS.

J Clin Invest. 2008 Jul. 118(7):2640-50. PMID: 18551191

Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2.

Furuhashi M, Tuncman G, Görgün CZ, Makowski L, Atsumi G, Vaillancourt E, Kono K, Babaev VR, Fazio S, Linton MF, Sulsky R, Robl JA, Parker RA, Hotamisligil GS.

Nature. 2007 Jun 21. 447(7147):959-65. PMID: 17554340

Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance.

Tuncman G, Hirosumi J, Solinas G, Chang L, Karin M, Hotamisligil GS.

Proc Natl Acad Sci U S A. 2006 Jul 11. 103(28):10741-6. PMID: 16818881

A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease.

Tuncman G, Erbay E, Hom X, De Vivo I, Campos H, Rimm EB, Hotamisligil GS.

Proc Natl Acad Sci U S A. 2006 May 02. 103(18):6970-5. PMID: 16641093

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes.

Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, Tuncman G, Görgün C, Glimcher LH, Hotamisligil GS.

Science. 2004 Oct 15. 306(5695):457-61. PMID: 15486293