Jean Schaffer

The Association Between C24:0/C16:0 Ceramide Ratio and Cardiorespiratory Fitness is Robust to Effect Modifications by Age and Sex.

Zatloukal J, Zylla S, Markus MRP, Ewert R, Gläser S, Völzke H, Albrecht D, Friedrich N, Nauck M, Peterson LR, Jiang X, Schaffer JE, Felix SB, Dörr M, Bahls M, Gross S, Zatloukal J, Zylla S, Markus MRP, Ewert R, Gläser S, Völzke H, Albrecht D, Friedrich N, Nauck M, Peterson LR, Jiang X, Schaffer JE, Felix SB, Dörr M, Bahls M, Gross S, Zatloukal J, Zylla S, Markus MRP, Ewert R, Gläser S, Völzke H, Albrecht D, Friedrich N, Nauck M, Peterson LR, Jiang X, Schaffer JE, Felix SB, Dörr M, Bahls M, Gross S.

Adv Biol (Weinh). 2024 04. 8(4):e2300633. PMID: 38342586

Sustained hyperglycemia specifically targets translation of mRNAs for insulin secretion.

Cheruiyot A, Hollister-Lock J, Sullivan B, Pan H, Dreyfuss JM, Bonner-Weir S, Schaffer JE.

J Clin Invest. 2023 Nov 30. 134(3). PMID: 38032734

Sustained hyperglycemia specifically targets translation of mRNAs for insulin secretion.

Cheruiyot A, Hollister-Lock J, Sullivan B, Pan H, Dreyfuss JM, Bonner-Weir S, Schaffer JE.

bioRxiv. 2023 Sep 29. PMID: 37808767

Previously unknown pathway for lipid biosynthesis discovered.

Schaffer JE.

Nature. 2023 Sep. 621(7977):47-48. PMID: 37648821

A pentasaccharide for monitoring pharmacodynamic response to gene therapy in GM1 gangliosidosis.

Kell P, Sidhu R, Qian M, Mishra S, Nicoli ER, D'Souza P, Tifft CJ, Gross AL, Gray-Edwards HL, Martin DR, Sena-Esteves M, Dietzen DJ, Singh M, Luo J, Schaffer JE, Ory DS, Jiang X.

EBioMedicine. 2023 Jun. 92:104627. PMID: 37267847

Author Correction: Loss of SNORA73 reprograms cellular metabolism and protects against steatohepatitis.

Sletten AC, Davidson JW, Yagabasan B, Moores S, Schwaiger-Haber M, Fujiwara H, Gale S, Jiang X, Sidhu R, Gelman SJ, Zhao S, Patti GJ, Ory DS, Schaffer JE.

Nat Commun. 2021 Nov 24. 12(1):6993. PMID: 34819504

Loss of SNORA73 reprograms cellular metabolism and protects against steatohepatitis.

Sletten AC, Davidson JW, Yagabasan B, Moores S, Schwaiger-Haber M, Fujiwara H, Gale S, Jiang X, Sidhu R, Gelman SJ, Zhao S, Patti GJ, Ory DS, Schaffer JE.

Nat Commun. 2021 09 01. 12(1):5214. PMID: 34471131

Validation of Trifluoromethylphenyl Diazirine Cholesterol Analogues As Cholesterol Mimetics and Photolabeling Reagents.

Krishnan K, Qian M, Feltes M, Chen ZW, Gale S, Wang L, Sugasawa Y, Reichert DE, Schaffer JE, Ory DS, Evers AS, Covey DF.

ACS Chem Biol. 2021 08 20. 16(8):1493-1507. PMID: 34355883

Application of a glycinated bile acid biomarker for diagnosis and assessment of response to treatment in Niemann-pick disease type C1.

Sidhu R, Kell P, Dietzen DJ, Farhat NY, Do AND, Porter FD, Berry-Kravis E, Reunert J, Marquardt T, Giugliani R, Lourenço CM, Wang RY, Movsesyan N, Plummer E, Schaffer JE, Ory DS, Jiang X.

Mol Genet Metab. 2020 12. 131(4):405-417. PMID: 33257258

Alterations in plasma triglycerides and ceramides: links with cardiac function in humans with type 2 diabetes.

Peterson LR, Jiang X, Chen L, Goldberg AC, Farmer MS, Ory DS, Schaffer JE.

J Lipid Res. 2020 07. 61(7):1065-1074. PMID: 32393551