Prospectively shared control data across concurrent randomised clinical trials.
Kotecha G, Ventz S, Trippa L.
Eur J Cancer. 2022 Dec 12. 181:18-20. PMID: 36621117
Primary Faculty
Lorenzo Trippa
Overview
I am interested in the development of adaptive clinical trial designs. My research includes the study of algorithms and methodologies for the analysis of data generated by adaptive trials. I am also particularly interested in Bayesian nonparametrics, a great source of modeling opportunity in biomedical applications as well as, both computational and theoretical problems.
Bibliography
Immune biomarkers of response to immunotherapy in patients with high-risk smoldering myeloma.
Sklavenitis-Pistofidis R, Aranha MP, Redd RA, Baginska J, Haradhvala NJ, Hallisey M, Dutta AK, Savell A, Varmeh S, Heilpern-Mallory D, Ujwary S, Zavidij O, Aguet F, Su NK, Lightbody ED, Bustoros M, Tahri S, Mouhieddine TH, Wu T, Flechon L, Anand S, Rosenblatt JM, Zonder J, Vredenburgh JJ, Boruchov A, Bhutani M, Usmani SZ, Matous J, Yee AJ, Jakubowiak A, Laubach J, Manier S, Nadeem O, Richardson P, Badros AZ, Mateos MV, Trippa L, Getz G, Ghobrial IM.
Cancer Cell. 2022 11 14. 40(11):1358-1373.e8. PMID: 36379208
The design and evaluation of hybrid controlled trials that leverage external data and randomization.
Ventz S, Khozin S, Louv B, Sands J, Wen PY, Rahman R, Comment L, Alexander BM, Trippa L.
Nat Commun. 2022 10 02. 13(1):5783. PMID: 36184621
A validation of models for prediction of pathogenic variants in mismatch repair genes.
Shyr C, Blackford AL, Huang T, Ke J, Ouardaoui N, Trippa L, Syngal S, Ukaegbu C, Uno H, Nafa K, Stadler ZK, Offit K, Amos CI, Lynch PM, Chen S, Giardiello FM, Buchanan DD, Hopper JL, Jenkins MA, Southey MC, Win AK, Figueiredo JC, Braun D, Parmigiani G.
Genet Med. 2022 10. 24(10):2155-2166. PMID: 35997715
Novel Clinical Trial Designs in Neuro-Oncology.
Saraf A, Trippa L, Rahman R.
Neurotherapeutics. 2022 10. 19(6):1844-1854. PMID: 35969361
Designing and conducting adaptive trials to evaluate interventions in health services and implementation research: practical considerations.
Lauffenburger JC, Choudhry NK, Russo M, Glynn RJ, Ventz S, Trippa L.
BMJ Med. 2022. 1(1). PMID: 36386444
Genetic subtypes of smoldering multiple myeloma are associated with distinct pathogenic phenotypes and clinical outcomes.
Bustoros M, Anand S, Sklavenitis-Pistofidis R, Redd R, Boyle EM, Zhitomirsky B, Dunford AJ, Tai YT, Chavda SJ, Boehner C, Neuse CJ, Rahmat M, Dutta A, Casneuf T, Verona R, Kastritis E, Trippa L, Stewart C, Walker BA, Davies FE, Dimopoulos MA, Bergsagel PL, Yong K, Morgan GJ, Aguet F, Getz G, Ghobrial IM.
Nat Commun. 2022 06 15. 13(1):3449. PMID: 35705541
Empirical Evaluations of Clinical Trial Designs.
Trippa L, Bacallado S.
JAMA Netw Open. 2022 05 02. 5(5):e2211620. PMID: 35544143
Clonal hematopoiesis is associated with increased risk of progression of asymptomatic Waldenström macroglobulinemia.
Tahri S, Mouhieddine TH, Redd R, Lampe L, Nilsson KI, El-Khoury H, Su NK, Nassar AH, Adib E, Bindra G, Abou Alaiwi S, Trippa L, Steensma DP, Castillo JJ, Treon SP, Ghobrial IM, Sperling AS.
Blood Adv. 2022 04 12. 6(7):2230-2235. PMID: 34847227
Prevalence of monoclonal gammopathies and clinical outcomes in a high-risk US population screened by mass spectrometry: a multicentre cohort study.
El-Khoury H, Lee DJ, Alberge JB, Redd R, Cea-Curry CJ, Perry J, Barr H, Murphy C, Sakrikar D, Barnidge D, Bustoros M, Leblebjian H, Cowan A, Davis MI, Amstutz J, Boehner CJ, Lightbody ED, Sklavenitis-Pistofidis R, Perkins MC, Harding S, Mo CC, Kapoor P, Mikhael J, Borrello IM, Fonseca R, Weiss ST, Karlson E, Trippa L, Rebbeck TR, Getz G, Marinac CR, Ghobrial IM.
Lancet Haematol. 2022 May. 9(5):e340-e349. PMID: 35344689