External Control Arms and Data Analysis Methods in Nonrandomized Trial of Patients With Glioblastoma.
Rahman R, Ventz S, Trippa L.
JAMA Oncol. 2023 07 01. 9(7):1006-1007. PMID: 37200026
Primary Faculty
Lorenzo Trippa
Overview
I am interested in the development of adaptive clinical trial designs. My research includes the study of algorithms and methodologies for the analysis of data generated by adaptive trials. I am also particularly interested in Bayesian nonparametrics, a great source of modeling opportunity in biomedical applications as well as, both computational and theoretical problems.
Bibliography
Looking ahead in early-phase trial design to improve the drug development process: examples in oncology.
Vanderbeek AM, Redd RA, Ventz S, Trippa L.
BMC Med Res Methodol. 2023 Jun 29. 23(1):151. PMID: 37386450
Accessible Data Collections for Improved Decision Making in Neuro-Oncology Clinical Trials.
Rahman R, Ventz S, Redd R, Cloughesy T, Alexander BM, Wen PY, Trippa L.
Clin Cancer Res. 2023 06 13. 29(12):2194-2198. PMID: 36939557
Personalised progression prediction in patients with monoclonal gammopathy of undetermined significance or smouldering multiple myeloma (PANGEA): a retrospective, multicohort study.
Cowan A, Ferrari F, Freeman SS, Redd R, El-Khoury H, Perry J, Patel V, Kaur P, Barr H, Lee DJ, Lightbody E, Downey K, Argyelan D, Theodorakakou F, Fotiou D, Liacos CI, Kanellias N, Chavda SJ, Ainley L, Sandecká V, Pospíšilová L, Minarik J, Jungova A, Radocha J, Spicka I, Nadeem O, Yong K, Hájek R, Kastritis E, Marinac CR, Dimopoulos MA, Get G, Trippa L, Ghobrial IM.
Lancet Haematol. 2023 Mar. 10(3):e203-e212. PMID: 36858677
Combining Breast Cancer Risk Prediction Models.
Guan Z, Huang T, McCarthy AM, Hughes K, Semine A, Uno H, Trippa L, Parmigiani G, Braun D.
Cancers (Basel). 2023 Feb 08. 15(4). PMID: 36831433
Validation of Predictive Analyses for Interim Decisions in Clinical Trials.
Avalos-Pacheco A, Ventz S, Arfè A, Alexander BM, Rahman R, Wen PY, Trippa L.
JCO Precis Oncol. 2023 02. 7:e2200606. PMID: 36848613
Prospectively shared control data across concurrent randomised clinical trials.
Kotecha G, Ventz S, Trippa L.
Eur J Cancer. 2023 03. 181:18-20. PMID: 36621117
Immune biomarkers of response to immunotherapy in patients with high-risk smoldering myeloma.
Sklavenitis-Pistofidis R, Aranha MP, Redd RA, Baginska J, Haradhvala NJ, Hallisey M, Dutta AK, Savell A, Varmeh S, Heilpern-Mallory D, Ujwary S, Zavidij O, Aguet F, Su NK, Lightbody ED, Bustoros M, Tahri S, Mouhieddine TH, Wu T, Flechon L, Anand S, Rosenblatt JM, Zonder J, Vredenburgh JJ, Boruchov A, Bhutani M, Usmani SZ, Matous J, Yee AJ, Jakubowiak A, Laubach J, Manier S, Nadeem O, Richardson P, Badros AZ, Mateos MV, Trippa L, Getz G, Ghobrial IM.
Cancer Cell. 2022 11 14. 40(11):1358-1373.e8. PMID: 36379208
The design and evaluation of hybrid controlled trials that leverage external data and randomization.
Ventz S, Khozin S, Louv B, Sands J, Wen PY, Rahman R, Comment L, Alexander BM, Trippa L.
Nat Commun. 2022 10 02. 13(1):5783. PMID: 36184621
A validation of models for prediction of pathogenic variants in mismatch repair genes.
Shyr C, Blackford AL, Huang T, Ke J, Ouardaoui N, Trippa L, Syngal S, Ukaegbu C, Uno H, Nafa K, Stadler ZK, Offit K, Amos CI, Lynch PM, Chen S, Giardiello FM, Buchanan DD, Hopper JL, Jenkins MA, Southey MC, Win AK, Figueiredo JC, Braun D, Parmigiani G.
Genet Med. 2022 10. 24(10):2155-2166. PMID: 35997715