Luca Pinello

Joint genotypic and phenotypic outcome modeling improves base editing variant effect quantification.

Ryu J, Barkal S, Yu T, Jankowiak M, Zhou Y, Francoeur M, Phan QV, Li Z, Tognon M, Brown L, Love MI, Lettre G, Ascher DB, Cassa CA, Sherwood RI, Pinello L.

medRxiv. 2023 Sep 10. PMID: 37732177

Loss-of-function lesions impact B-cell development and fitness but are insufficient to drive CLL in mouse models.

ten Hacken E, Yin S, Redd R, Hernández Sánchez M, Clement K, Hoffmann GB, Regis FF, Witten E, Li S, Neuberg D, Pinello L, Livak KJ, Wu CJ.

Blood Adv. 2023 08 22. 7(16):4514-4517. PMID: 36477552

Dictys: dynamic gene regulatory network dissects developmental continuum with single-cell multiomics.

Wang L, Trasanidis N, Wu T, Dong G, Hu M, Bauer DE, Pinello L.

Nat Methods. 2023 09. 20(9):1368-1378. PMID: 37537351

SIMBA: single-cell embedding along with features.

Chen H, Ryu J, Vinyard ME, Lerer A, Pinello L.

Nat Methods. 2023 May 29. PMID: 37248389

Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells.

Zeng J, Nguyen MA, Liu P, Ferreira da Silva L, Lin LY, Justus DG, Petri K, Clement K, Porter SN, Verma A, Neri NR, Rosanwo T, Ciuculescu MF, Abriss D, Mintzer E, Maitland SA, Demirci S, Tisdale JF, Williams DA, Zhu LJ, Pruett-Miller SM, Pinello L, Joung JK, Pattanayak V, Manis JP, Armant M, Pellin D, Brendel C, Wolfe SA, Bauer DE.

bioRxiv. 2023 May 27. PMID: 37292647

A survey on algorithms to characterize transcription factor binding sites.

Tognon M, Giugno R, Pinello L.

Brief Bioinform. 2023 05 19. 24(3). PMID: 37099664

Integrative dissection of gene regulatory elements at base resolution.

Chen Z, Javed N, Moore M, Wu J, Sun G, Vinyard M, Collins A, Pinello L, Najm FJ, Bernstein BE.

Cell Genom. 2023 Jun 14. 3(6):100318. PMID: 37388913

A molecular glue approach to control the half-life of CRISPR-based technologies.

Sreekanth V, Jan M, Zhao KT, Lim D, Davis JR, McConkey M, Kovalcik V, Barkal S, Law BK, Fife J, Tian R, Vinyard ME, Becerra B, Kampmann M, Sherwood RI, Pinello L, Liu DR, Ebert BL, Choudhary A.

bioRxiv. 2023 Mar 20. PMID: 36945568

Human genetic diversity alters off-target outcomes of therapeutic gene editing.

Cancellieri S, Zeng J, Lin LY, Tognon M, Nguyen MA, Lin J, Bombieri N, Maitland SA, Ciuculescu MF, Katta V, Tsai SQ, Armant M, Wolfe SA, Giugno R, Bauer DE, Pinello L.

Nat Genet. 2023 01. 55(1):34-43. PMID: 36522432

Precise DNA cleavage using CRISPR-SpRYgests.

Christie KA, Guo JA, Silverstein RA, Doll RM, Mabuchi M, Stutzman HE, Lin J, Ma L, Walton RT, Pinello L, Robb GB, Kleinstiver BP.

Nat Biotechnol. 2023 03. 41(3):409-416. PMID: 36203014