MOSAIC enables in situ saturation mutagenesis of genes and CRISPR prime editing guide RNA optimization in human cells.
Hsu JY, Lam KC, Shih J, Pinello L, Joung JK.
bioRxiv. 2024 Apr 26. PMID: 38712243
Other Positions
Associate Professor of Pathology
Pathology-Massachusetts General Hospital
Harvard Medical School
Bibliography
CRISPR PERSIST-On enables heritable and fine-tunable human gene activation.
Tak YE, Hsu JY, Shih J, Schultz HT, Nguyen IT, Lam KC, Pinello L, Keith Joung J.
bioRxiv. 2024 Apr 26. PMID: 38712303
Joint genotypic and phenotypic outcome modeling improves base editing variant effect quantification.
Ryu J, Barkal S, Yu T, Jankowiak M, Zhou Y, Francoeur M, Phan QV, Li Z, Tognon M, Brown L, Love MI, Bhat V, Lettre G, Ascher DB, Cassa CA, Sherwood RI, Pinello L.
Nat Genet. 2024 May. 56(5):925-937. PMID: 38658794
Defining and benchmarking open problems in single-cell analysis.
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Res Sq. 2024 Apr 04. PMID: 38645152
DNA-Diffusion: Leveraging Generative Models for Controlling Chromatin Accessibility and Gene Expression via Synthetic Regulatory Elements.
DaSilva LF, Senan S, Patel ZM, Janardhan Reddy A, Gabbita S, Nussbaum Z, Valdez Córdova CM, Wenteler A, Weber N, Tunjic TM, Ahmad Khan T, Li Z, Smith C, Bejan M, Karmel Louis L, Cornejo P, Connell W, Wong ES, Meuleman W, Pinello L.
bioRxiv. 2024 Feb 01. PMID: 38352499
Statistical inference with a manifold-constrained RNA velocity model uncovers cell cycle speed modulations.
Lederer AR, Leonardi M, Talamanca L, Herrera A, Droin C, Khven I, Carvalho HJF, Valente A, Mantes AD, Arabí PM, Pinello L, Naef F, Manno G.
bioRxiv. 2024 Jan 22. PMID: 38328127
Benchmarking computational methods to identify spatially variable genes and peaks.
Li Z, Patel ZM, Song D, Yan G, Li JJ, Pinello L.
bioRxiv. 2023 Dec 03. PMID: 38076922
Joint genotypic and phenotypic outcome modeling improves base editing variant effect quantification.
Ryu J, Barkal S, Yu T, Jankowiak M, Zhou Y, Francoeur M, Phan QV, Li Z, Tognon M, Brown L, Love MI, Lettre G, Ascher DB, Cassa CA, Sherwood RI, Pinello L.
medRxiv. 2023 Sep 10. PMID: 37732177
Loss-of-function lesions impact B-cell development and fitness but are insufficient to drive CLL in mouse models.
ten Hacken E, Yin S, Redd R, Hernández Sánchez M, Clement K, Hoffmann GB, Regis FF, Witten E, Li S, Neuberg D, Pinello L, Livak KJ, Wu CJ.
Blood Adv. 2023 08 22. 7(16):4514-4517. PMID: 36477552
Dictys: dynamic gene regulatory network dissects developmental continuum with single-cell multiomics.
Wang L, Trasanidis N, Wu T, Dong G, Hu M, Bauer DE, Pinello L.
Nat Methods. 2023 09. 20(9):1368-1378. PMID: 37537351