Luca Pinello

A molecular glue approach to control the half-life of CRISPR-based technologies.

Sreekanth V, Jan M, Zhao KT, Lim D, Davis JR, McConkey M, Kovalcik V, Barkal S, Law BK, Fife J, Tian R, Vinyard ME, Becerra B, Kampmann ME, Sherwood RI, Pinello L, Liu DR, Ebert BL, Choudhary A.

bioRxiv. 2023 Mar 20. PMID: 36945568

Human genetic diversity alters off-target outcomes of therapeutic gene editing.

Cancellieri S, Zeng J, Lin LY, Tognon M, Nguyen MA, Lin J, Bombieri N, Maitland SA, Ciuculescu MF, Katta V, Tsai SQ, Armant M, Wolfe SA, Giugno R, Bauer DE, Pinello L.

Nat Genet. 2023 01. 55(1):34-43. PMID: 36522432

Loss-of-function lesions impact B-cell development and fitness but are insufficient to drive CLL in mouse models.

Ten Hacken E, Yin S, Redd RA, Hernández Sánchez M, Clement K, Brunsting Hoffmann G, Regis FFD, Witten E, Li S, Neuberg D, Pinello L, Livak KJ, Wu CJ.

Blood Adv. 2022 Dec 07. PMID: 36477552

Precise DNA cleavage using CRISPR-SpRYgests.

Christie KA, Guo JA, Silverstein RA, Doll RM, Mabuchi M, Stutzman HE, Lin J, Ma L, Walton RT, Pinello L, Robb GB, Kleinstiver BP.

Nat Biotechnol. 2023 Mar. 41(3):409-416. PMID: 36203014

Single-cell analysis and functional characterization uncover the stem cell hierarchies and developmental origins of rhabdomyosarcoma.

Wei Y, Qin Q, Yan C, Hayes MN, Garcia SP, Xi H, Do D, Jin AH, Eng TC, McCarthy KM, Adhikari A, Onozato ML, Spentzos D, Neilsen GP, Iafrate AJ, Wexler LH, Pyle AD, Suvà ML, Dela Cruz F, Pinello L, Langenau DM.

Nat Cancer. 2022 08. 3(8):961-975. PMID: 35982179

Author Correction: Augmenting and directing long-range CRISPR-mediated activation in human cells.

Tak YE, Horng JE, Perry NT, Schultz HT, Iyer S, Yao Q, Zou LS, Aryee MJ, Pinello L, Joung JK.

Nat Methods. 2022 Jul. 19(7):899. PMID: 35761069

Author Correction: CRISPR prime editing with ribonucleoprotein complexes in zebrafish and primary human cells.

Petri K, Zhang W, Ma J, Schmidts A, Lee H, Horng JE, Kim DY, Kurt IC, Clement K, Hsu JY, Pinello L, Maus MV, Joung JK, Yeh JJ.

Nat Biotechnol. 2022 Feb. 40(2):273. PMID: 33986547

singlecellVR: Interactive Visualization of Single-Cell Data in Virtual Reality.

Stein DF, Chen H, Vinyard ME, Qin Q, Combs RD, Zhang Q, Pinello L.

Front Genet. 2021. 12:764170. PMID: 34777482

Three subtypes of lung cancer fibroblasts define distinct therapeutic paradigms.

Hu H, Piotrowska Z, Hare PJ, Chen H, Mulvey HE, Mayfield A, Noeen S, Kattermann K, Greenberg M, Williams A, Riley AK, Wilson JJ, Mao YQ, Huang RP, Banwait MK, Ho J, Crowther GS, Hariri LP, Heist RS, Kodack DP, Pinello L, Shaw AT, Mino-Kenudson M, Hata AN, Sequist LV, Benes CH, Niederst MJ, Engelman JA.

Cancer Cell. 2021 11 08. 39(11):1531-1547.e10. PMID: 34624218

GRAFIMO: Variant and haplotype aware motif scanning on pangenome graphs.

Tognon M, Bonnici V, Garrison E, Giugno R, Pinello L.

PLoS Comput Biol. 2021 09. 17(9):e1009444. PMID: 34570769