Maria Mota

Sexual differentiation in human malaria parasites is regulated by competition between phospholipid metabolism and histone methylation.

Harris CT, Tong X, Campelo R, Marreiros IM, Vanheer LN, Nahiyaan N, Zuzarte-Luís VA, Deitsch KW, Mota MM, Rhee KY, Kafsack BFC.

Nat Microbiol. 2023 07. 8(7):1280-1292. PMID: 37277533

The nutrient games - Plasmodium metabolism during hepatic development.

Lahree A, Mello-Vieira J, Mota MM.

Trends Parasitol. 2023 06. 39(6):445-460. PMID: 37061442

A non-canonical sensing pathway mediates Plasmodium adaptation to amino acid deficiency.

Marreiros IM, Marques S, Parreira A, Mastrodomenico V, Mounce BC, Harris CT, Kafsack BF, Billker O, Zuzarte-Luís V, Mota MM.

Commun Biol. 2023 02 21. 6(1):205. PMID: 36810637

Interplay between liver and blood stages of Plasmodium infection dictates malaria severity via ?d T cells and IL-17-promoted stress erythropoiesis.

Chora ÂF, Marques S, Gonçalves JL, Lima P, Gomes da Costa D, Fernandez-Ruiz D, Marreiros MI, Ruivo P, Carvalho T, Ribeiro RM, Serre K, Heath WR, Silva-Santos B, Tate AT, Mota MM.

Immunity. 2023 03 14. 56(3):592-605.e8. PMID: 36804959

A spatiotemporally resolved single-cell atlas of the Plasmodium liver stage.

Afriat A, Zuzarte-Luís V, Bahar Halpern K, Buchauer L, Marques S, Chora ÂF, Lahree A, Amit I, Mota MM, Itzkovitz S.

Nature. 2022 Nov. 611(7936):563-569. PMID: 36352220

Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance.

Tye MA, Payne NC, Johansson C, Singh K, Santos SA, Fagbami L, Pant A, Sylvester K, Luth MR, Marques S, Whitman M, Mota MM, Winzeler EA, Lukens AK, Derbyshire ER, Oppermann U, Wirth DF, Mazitschek R.

Nat Commun. 2022 08 25. 13(1):4976. PMID: 36008486

Host lung microbiota promotes malaria-associated acute respiratory distress syndrome.

Mukherjee D, Chora ÂF, Lone JC, Ramiro RS, Blankenhaus B, Serre K, Ramirez M, Gordo I, Veldhoen M, Varga-Weisz P, Mota MM.

Nat Commun. 2022 06 29. 13(1):3747. PMID: 35768411

Active APPL1 sequestration by Plasmodium favors liver-stage development.

Lahree A, Baptista SJS, Marques S, Perschin V, Zuzarte-Luís V, Goel M, Choudhary HH, Mishra S, Stigloher C, Zerial M, Sundaramurthy V, Mota MM.

Cell Rep. 2022 05 31. 39(9):110886. PMID: 35649358

Plasmodium parasitophorous vacuole membrane-resident protein UIS4 manipulates host cell actin to avoid parasite elimination.

M'Bana V, Lahree A, Marques S, Slavic K, Mota MM.

iScience. 2022 May 20. 25(5):104281. PMID: 35573190

The reciprocal influence of the liver and blood stages of the malaria parasite's life cycle.

Chora ÂF, Mota MM, Prudêncio M.

Int J Parasitol. 2022 Oct. 52(11):711-715. PMID: 35367213