Mark R Sullivan

Arginase Therapy Combines Effectively with Immune Checkpoint Blockade or Agonist Anti-OX40 Immunotherapy to Control Tumor Growth.

Badeaux MD, Rolig AS, Agnello G, Enzler D, Kasiewicz MJ, Priddy L, Wiggins JF, Muir A, Sullivan MR, Van Cleef J, Daige C, Vander Heiden MG, Rajamanickam V, Wooldridge JE, Redmond WL, Rowlinson SW.

Cancer Immunol Res. 2021 Jan 26. PMID: 33500272

Isolation and Quantification of Metabolite Levels in Murine Tumor Interstitial Fluid by LC/MS.

Sullivan MR, Lewis CA, Muir A.

Bio Protoc. 2019 Nov 20. 9(22):e3427. PMID: 33654924

Deoxycytidine Release from Pancreatic Stellate Cells Promotes Gemcitabine Resistance.

Dalin S, Sullivan MR, Lau AN, Grauman-Boss B, Mueller HS, Kreidl E, Fenoglio S, Luengo A, Lees JA, Vander Heiden MG, Lauffenburger DA, Hemann MT.

Cancer Res. 2019 11 15. 79(22):5723-5733. PMID: 31484670

Increased PHGDH expression promotes aberrant melanin accumulation.

Mattaini KR, Sullivan MR, Lau AN, Fiske BP, Bronson RT, Vander Heiden MG.

BMC Cancer. 2019 Jul 22. 19(1):723. PMID: 31331318

Determinants of nutrient limitation in cancer.

Sullivan MR, Vander Heiden MG.

Crit Rev Biochem Mol Biol. 2019 06. 54(3):193-207. PMID: 31162937

Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability.

Sullivan MR, Danai LV, Lewis CA, Chan SH, Gui DY, Kunchok T, Dennstedt EA, Vander Heiden MG, Muir A.

Elife. 2019 04 16. 8. PMID: 30990168

Increased Serine Synthesis Provides an Advantage for Tumors Arising in Tissues Where Serine Levels Are Limiting.

Sullivan MR, Mattaini KR, Dennstedt EA, Nguyen AA, Sivanand S, Reilly MF, Meeth K, Muir A, Darnell AM, Bosenberg MW, Lewis CA, Vander Heiden MG.

Cell Metab. 2019 06 04. 29(6):1410-1421.e4. PMID: 30905671

Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth.

Cox AG, Tsomides A, Yimlamai D, Hwang KL, Miesfeld J, Galli GG, Fowl BH, Fort M, Ma KY, Sullivan MR, Hosios AM, Snay E, Yuan M, Brown KK, Lien EC, Chhangawala S, Steinhauser ML, Asara JM, Houvras Y, Link B, Vander Heiden MG, Camargo FD, Goessling W.

EMBO J. 2018 11 15. 37(22). PMID: 30348863

Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells.

Vandekeere S, Dubois C, Kalucka J, Sullivan MR, García-Caballero M, Goveia J, Chen R, Diehl FF, Bar-Lev L, Souffreau J, Pircher A, Kumar S, Vinckier S, Hirabayashi Y, Furuya S, Schoonjans L, Eelen G, Ghesquière B, Keshet E, Li X, Vander Heiden MG, Dewerchin M, Carmeliet P.

Cell Metab. 2018 10 02. 28(4):573-587.e13. PMID: 30017355

When cancer needs what's non-essential.

Sullivan MR, Vander Heiden MG.

Nat Cell Biol. 2017 May. 19(5):418-420. PMID: 28422952