MCL-1 is a master regulator of cancer dependency on fatty acid oxidation.
Prew MS, Adhikary U, Choi DW, Portero EP, Paulo JA, Gowda P, Budhraja A, Opferman JT, Gygi SP, Danial NN, Walensky LD.
Cell Rep. 2022 10 04. 41(1):111445. PMID: 36198266
Secondary Faculty
Nika Danial
Associate Professor in the Department of Molecular Metabolism
Molecular Metabolism
Other Positions
Associate Professor of Medicine
Medicine-Brigham and Women's Hospital
Harvard Medical School
Links
Bibliography
Mitochondrial pyruvate supports lymphoma proliferation by fueling a glutamate pyruvate transaminase 2-dependent glutaminolysis pathway.
Wei P, Bott AJ, Cluntun AA, Morgan JT, Cunningham CN, Schell JC, Ouyang Y, Ficarro SB, Marto JA, Danial NN, DeBerardinis RJ, Rutter J.
Sci Adv. 2022 Sep 30. 8(39):eabq0117. PMID: 36179030
Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets.
Fu A, van Rooyen L, Evans L, Armstrong N, Avizonis D, Kin T, Bird GH, Reddy A, Chouchani ET, Liesa-Roig M, Walensky LD, Shapiro AMJ, Danial NN.
Cell Rep. 2021 11 23. 37(8):110037. PMID: 34818536
More Metabolism!
Olzmann JA, Fendt SM, Shah YM, Vousden K, Chandel N, Horng T, Danial N, Tu B, Christofk H, Vander Heiden MG, Wellen K.
Mol Cell. 2021 09 16. 81(18):3659-3664. PMID: 34547228
BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models.
Githaka JM, Tripathi N, Kirschenman R, Patel N, Pandya V, Kramer DA, Montpetit R, Zhu LF, Sonenberg N, Fahlman RP, Danial NN, Underhill DA, Goping IS.
Nat Commun. 2021 05 19. 12(1):2939. PMID: 34011960
UCP1 governs liver extracellular succinate and inflammatory pathogenesis.
Mills EL, Harmon C, Jedrychowski MP, Xiao H, Garrity R, Tran NV, Bradshaw GA, Fu A, Szpyt J, Reddy A, Prendeville H, Danial NN, Gygi SP, Lynch L, Chouchani ET.
Nat Metab. 2021 05. 3(5):604-617. PMID: 34002097
Development of a novel fluorescent biosensor for dynamic monitoring of metabolic methionine redox status in cells and tissues.
Choi DW, Roh YJ, Kim S, Lee HM, Kim M, Shin D, Park JH, Cho Y, Park HH, Ok YS, Kang D, Kim JH, Tarrago L, Danial NN, Gladyshev VN, Min PK, Lee BC.
Biosens Bioelectron. 2021 Apr 15. 178:113031. PMID: 33571808
CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice.
Wang CH, Lundh M, Fu A, Kriszt R, Huang TL, Lynes MD, Leiria LO, Shamsi F, Darcy J, Greenwood BP, Narain NR, Tolstikov V, Smith KL, Emanuelli B, Chang YT, Hagen S, Danial NN, Kiebish MA, Tseng YH.
Sci Transl Med. 2020 08 26. 12(558). PMID: 32848096
Hydrocarbon-Stitched Peptide Agonists of Glucagon-Like Peptide-1 Receptor.
Bird GH, Fu A, Escudero S, Godes M, Opoku-Nsiah K, Wales TE, Cameron MD, Engen JR, Danial NN, Walensky LD.
ACS Chem Biol. 2020 06 19. 15(6):1340-1348. PMID: 32348108
Glucose-dependent partitioning of arginine to the urea cycle protects ß-cells from inflammation.
Fu A, Alvarez-Perez JC, Avizonis D, Kin T, Ficarro SB, Choi DW, Karakose E, Badur MG, Evans L, Rosselot C, Bridon G, Bird GH, Seo HS, Dhe-Paganon S, Kamphorst JJ, Stewart AF, James Shapiro AM, Marto JA, Walensky LD, Jones RG, Garcia-Ocana A, Danial NN.
Nat Metab. 2020 05. 2(5):432-446. PMID: 32694660