Multiplexed detection of bacterial nucleic acids using Cas13 in droplet microarrays.
Thakku SG, Ackerman CM, Myhrvold C, Bhattacharyya RP, Livny J, Ma P, Gomez GI, Sabeti PC, Blainey PC, Hung DT.
PNAS Nexus. 2022 Mar. 1(1):pgac021. PMID: 35450424
Primary Faculty
Pardis Christine Sabeti
Professor of Immunology and Infectious Diseases
Immunology and Infectious Diseases
Other Positions
Professor of Organismic and Evolutionary Biology
OEB Instruction + Org Res -Other Academic
Harvard Faculty of Arts and Sciences
Overview
Dr. Sabeti's lab focuses on developing new analytical and genomic methods to study evolutionary adaptation and genetic diversity in humans and pathogens, with three current research foci: (1) Identifying and characterizing the underlying adaptive changes that have shaped the human species over time; and (2) Investigating genetic diversity in pathogens such as Lassa virus, Ebola virus, Zika virus, and Babesia microti, towards improved diagnostics, surveillance, and interventions, and (3) Developing novels tools to detect and diagnose microbes causing human morbidity and mortality.
B.S., 1997
M.I.T.
M.Sc., 1998
University of Oxford
D.Phil., 2003
University of Oxford
M.D., 2006
Harvard Medical School
Bibliography
Comparative transmissibility of SARS-CoV-2 variants Delta and Alpha in New England, USA.
Earnest R, Uddin R, Matluk N, Renzette N, Turbett SE, Siddle KJ, Loreth C, Adams G, Tomkins-Tinch CH, Petrone ME, Rothman JE, Breban MI, Koch RT, Billig K, Fauver JR, Vogels CBF, Bilguvar K, De Kumar B, Landry ML, Peaper DR, Kelly K, Omerza G, Grieser H, Meak S, Martha J, Dewey HB, Kales S, Berenzy D, Carpenter-Azevedo K, King E, Huard RC, Novitsky V, Howison M, Darpolor J, Manne A, Kantor R, Smole SC, Brown CM, Fink T, Lang AS, Gallagher GR, Pitzer VE, Sabeti PC, Gabriel S, MacInnis BL, Tewhey R, Adams MD, Park DJ, Lemieux JE, Grubaugh ND.
Cell Rep Med. 2022 Apr 19. 3(4):100583. PMID: 35480627
Designing sensitive viral diagnostics with machine learning.
Metsky HC, Welch NL, Pillai PP, Haradhvala NJ, Rumker L, Mantena S, Zhang YB, Yang DK, Ackerman CM, Weller J, Blainey PC, Myhrvold C, Mitzenmacher M, Sabeti PC.
Nat Biotechnol. 2022 Mar 03. PMID: 35241837
Analysis of 6.4 million SARS-CoV-2 genomes identifies mutations associated with fitness.
Obermeyer F, Jankowiak M, Barkas N, Schaffner SF, Pyle JD, Yurkovetskiy L, Bosso M, Park DJ, Babadi M, MacInnis BL, Luban J, Sabeti PC, Lemieux JE.
medRxiv. 2022 Feb 16. PMID: 35194619
Multiplexed CRISPR-based microfluidic platform for clinical testing of respiratory viruses and identification of SARS-CoV-2 variants.
Welch NL, Zhu M, Hua C, Weller J, Mirhashemi ME, Nguyen TG, Mantena S, Bauer MR, Shaw BM, Ackerman CM, Thakku SG, Tse MW, Kehe J, Uwera MM, Eversley JS, Bielwaski DA, McGrath G, Braidt J, Johnson J, Cerrato F, Moreno GK, Krasilnikova LA, Petros BA, Gionet GL, King E, Huard RC, Jalbert SK, Cleary ML, Fitzgerald NA, Gabriel SB, Gallagher GR, Smole SC, Madoff LC, Brown CM, Keller MW, Wilson MM, Kirby MK, Barnes JR, Park DJ, Siddle KJ, Happi CT, Hung DT, Springer M, MacInnis BL, Lemieux JE, Rosenberg E, Branda JA, Blainey PC, Sabeti PC, Myhrvold C.
Nat Med. 2022 May. 28(5):1083-1094. PMID: 35130561
Bioterrorism: An analysis of biological agents used in terrorist events.
Tin D, Sabeti P, Ciottone GR.
Am J Emerg Med. 2022 Apr. 54:117-121. PMID: 35152120
The case for altruism in institutional diagnostic testing.
Specht I, Sani K, Botti-Lodovico Y, Hughes M, Heumann K, Bronson A, Marshall J, Baron E, Parrie E, Glennon O, Fry B, Colubri A, Sabeti PC.
Sci Rep. 2022 02 03. 12(1):1857. PMID: 35115545
Containing the spread of mumps on college campuses.
Shah M, Ferra G, Fitzgerald S, Barreira PJ, Sabeti PC, Colubri A.
R Soc Open Sci. 2022 Jan. 9(1):210948. PMID: 35116142
Serological Markers of SARS-CoV-2 Reinfection.
Siddiqui SM, Bowman KA, Zhu AL, Fischinger S, Beger S, Maron JS, Bartsch YC, Atyeo C, Gorman MJ, Yanis A, Hultquist JF, Lorenzo-Redondo R, Ozer EA, Simons LM, Talj R, Rankin DA, Chapman L, Meade K, Steinhart J, Mullane S, Siebert S, Streeck H, Sabeti P, Halasa N, Musk ER, Barouch DH, Menon AS, Nilles EJ, Lauffenburger DA, Alter G.
mBio. 2022 Jan 25. e0214121. PMID: 35073738
Detection of Neanderthal Adaptively Introgressed Genetic Variants That Modulate Reporter Gene Expression in Human Immune Cells.
Jagoda E, Xue JR, Reilly SK, Dannemann M, Racimo F, Huerta-Sanchez E, Sankararaman S, Kelso J, Pagani L, Sabeti PC, Capellini TD.
Mol Biol Evol. 2022 01 07. 39(1). PMID: 34662402
News
Machine learning tool can predict which COVID variants will cause case surges
Scientists have developed a machine learning model that can predict which SARS-CoV-2 viral variants are likely to cause surges in COVID-19 cases.
At a small Colorado university, COVID tracking goes high-tech
A collaboration between Colorado Mesa University and the Broad Institute of M.I.T. and Harvard has yielded “the most sophisticated system in the country to track outbreaks” of COVID-19, according Pardis Sabeti, a professor of immunology and infectious diseases…
Sharing COVID-19 testing resources could benefit companies, universities
Companies, universities, and other large organizations and institutions that are conducting regular COVID-19 testing among their members should consider expanding their testing efforts to nearby communities to better control the spread of the virus, according to new research…
Creating an early detection system for infectious diseases in Africa
Many African nations are extremely vulnerable to infectious disease outbreaks, including Ebola, Lassa fever, Zika, and West Nile virus. A March 17, 2021, Wired article looked at the joint effort of two scientists—Christian Happi and Pardis Sabeti—to develop…
Marc Lipsitch, Pardis Sabeti elected to National Academy of Medicine
Two Harvard T.H. Chan School of Public Health faculty members, Marc Lipsitch and Pardis Sabeti, have been elected to the National Academy of Medicine.
