Antigen test swabs are comparable to nasopharyngeal swabs for sequencing of SARS-CoV-2.
Hassouneh SA, Trujillo A, Ali S, Cella E, Johnston C, DeRuff KC, Sabeti PC, Azarian T.
Sci Rep. 2023 07 12. 13(1):11255. PMID: 37438412
Primary Faculty
Pardis Christine Sabeti
Professor of Immunology and Infectious Diseases
Immunology and Infectious Diseases
Other Positions
Professor of Organismic and Evolutionary Biology
OEB Instruction + Org Res -Other Academic
Harvard Faculty of Arts and Sciences
Overview
Dr. Sabeti's lab focuses on developing new analytical and genomic methods to study evolutionary adaptation and genetic diversity in humans and pathogens, with three current research foci: (1) Identifying and characterizing the underlying adaptive changes that have shaped the human species over time; and (2) Investigating genetic diversity in pathogens such as Lassa virus, Ebola virus, Zika virus, and Babesia microti, towards improved diagnostics, surveillance, and interventions, and (3) Developing novels tools to detect and diagnose microbes causing human morbidity and mortality.
Dr. Sabeti's computational genomic lab has contributed to widely varying fields — including human evolutionary biology, gene therapy, microbial sequencing, information theory, and disease surveillance. They aim to create comprehensive approaches for detecting, containing, and treating deadly infectious diseases, including Lassa virus, Ebola virus, Zika virus, and SARS-CoV-2. She has invested in capacity building and education throughout, co-founding the African Center for Excellence of Genomic of Infectious Disease, enabling the first diagnosis of Ebola in Sierra Leone and Nigeria, training thousands of scientists through extended educational programs, and establishing genome centers in West Africa.
B.S., 1997
M.I.T.
M.Sc., 1998
University of Oxford
D.Phil., 2003
University of Oxford
M.D., 2006
Harvard Medical School
Bibliography
Single-cell profiling of lncRNA expression during Ebola virus infection in rhesus macaques.
Santus L, Sopena-Rios M, García-Pérez R, Lin AE, Adams GC, Barnes KG, Siddle KJ, Wohl S, Reverter F, Rinn JL, Bennett RS, Hensley LE, Sabeti PC, Melé M.
Nat Commun. 2023 Jun 30. 14(1):3866. PMID: 37391481
The HLA-II immunopeptidome of SARS-CoV-2.
Weingarten-Gabbay S, Chen DY, Sarkizova S, Taylor HB, Gentili M, Pearlman LR, Bauer MR, Rice CM, Clauser KR, Hacohen N, Carr SA, Abelin JG, Saeed M, Sabeti PC.
bioRxiv. 2023 Jun 01. PMID: 37398281
Development of Cas13a-based Assays for Neisseria gonorrhoeae Detection and Gyrase A Determination.
Allan-Blitz LT, Shah P, Adams G, Branda JA, Klausner JD, Goldstein R, Sabeti PC, Lemieux JE.
medRxiv. 2023 May 26. PMID: 37293004
The functional and evolutionary impacts of human-specific deletions in conserved elements.
Xue JR, Mackay-Smith A, Mouri K, Garcia MF, Dong MX, Akers JF, Noble M, Li X, Lindblad-Toh K, Karlsson EK, Noonan JP, Capellini TD, Brennand KJ, Tewhey R, Sabeti PC, Reilly SK.
Science. 2023 04 28. 380(6643):eabn2253. PMID: 37104592
Evolutionary constraint and innovation across hundreds of placental mammals.
Christmas MJ, Kaplow IM, Genereux DP, Dong MX, Hughes GM, Li X, Sullivan PF, Hindle AG, Andrews G, Armstrong JC, Bianchi M, Breit AM, Diekhans M, Fanter C, Foley NM, Goodman DB, Goodman L, Keough KC, Kirilenko B, Kowalczyk A, Lawless C, Lind AL, Meadows JRS, Moreira LR, Redlich RW, Ryan L, Swofford R, Valenzuela A, Wagner F, Wallerman O, Brown AR, Damas J, Fan K, Gatesy J, Grimshaw J, Johnson J, Kozyrev SV, Lawler AJ, Marinescu VD, Morrill KM, Osmanski A, Paulat NS, Phan BN, Reilly SK, Schäffer DE, Steiner C, Supple MA, Wilder AP, Wirthlin ME, Xue JR, Birren BW, Gazal S, Hubley RM, Koepfli KP, Marques-Bonet T, Meyer WK, Nweeia M, Sabeti PC, Shapiro B, Smit AFA, Springer MS, Teeling EC, Weng Z, Hiller M, Levesque DL, Lewin HA, Murphy WJ, Navarro A, Paten B, Pollard KS, Ray DA, Ruf I, Ryder OA, Pfenning AR, Lindblad-Toh K, Karlsson EK.
Science. 2023 04 28. 380(6643):eabn3943. PMID: 37104599
CRISPR-Cas-amplified urinary biomarkers for multiplexed and portable cancer diagnostics.
Hao L, Zhao RT, Welch NL, Tan EKW, Zhong Q, Harzallah NS, Ngambenjawong C, Ko H, Fleming HE, Sabeti PC, Bhatia SN.
Nat Nanotechnol. 2023 07. 18(7):798-807. PMID: 37095220
Protecting public health in Iran in the face of oppression.
Patel T, Hammond A, Nasari A, Sani K, Dee EC, Jain B, Sabeti PC.
Nat Med. 2023 04. 29(4):767-768. PMID: 36806790
Neuropathological features of SARS-CoV-2 delta and omicron variants.
Normandin E, Valizadeh N, Rudmann EA, Uddin R, Dobbins ST, MacInnis BL, Padera RF, Siddle KJ, Lemieux JE, Sabeti PC, Mukerji SS, Solomon IH.
J Neuropathol Exp Neurol. 2023 03 20. 82(4):283-295. PMID: 36847705
Distinguishing Severe Acute Respiratory Syndrome Coronavirus 2 Persistence and Reinfection: A Retrospective Cohort Study.
Turbett SE, Tomkins-Tinch CH, Anahtar MN, Dugdale CM, Hyle EP, Shenoy ES, Shaw B, Egbuonu K, Bowman KA, Zachary KC, Adams GC, Hooper DC, Ryan ET, LaRocque RC, Bassett IV, Triant VA, Siddle KJ, Rosenberg E, Sabeti PC, Schaffner SF, MacInnis BL, Lemieux JE, Charles RC.
Clin Infect Dis. 2023 03 04. 76(5):850-860. PMID: 36268576
News
Experts reflect on COVID-19, share lessons for future pandemics
The U.S. response to the COVID-19 pandemic was full of missteps—ones that experts say can inform preparations for future global health emergencies.
Machine learning tool can predict which COVID variants will cause case surges
Scientists have developed a machine learning model that can predict which SARS-CoV-2 viral variants are likely to cause surges in COVID-19 cases.
At a small Colorado university, COVID tracking goes high-tech
A collaboration between Colorado Mesa University and the Broad Institute of M.I.T. and Harvard has yielded “the most sophisticated system in the country to track outbreaks” of COVID-19, according Pardis Sabeti, a professor of immunology and infectious diseases…
Sharing COVID-19 testing resources could benefit companies, universities
Companies, universities, and other large organizations and institutions that are conducting regular COVID-19 testing among their members should consider expanding their testing efforts to nearby communities to better control the spread of the virus, according to new research…
Creating an early detection system for infectious diseases in Africa
Many African nations are extremely vulnerable to infectious disease outbreaks, including Ebola, Lassa fever, Zika, and West Nile virus. A March 17, 2021, Wired article looked at the joint effort of two scientists—Christian Happi and Pardis Sabeti—to develop…