Resolving the deceptive isoform and complex selectivity of HDAC1/2 inhibitors.
Payne NC, Mazitschek R.
Cell Chem Biol. 2022 Mar 14. PMID: 35298895
Secondary Faculty
Ralph Mazitschek
Assistant Professor in the Department of Immunology and Infectious Diseases
Immunology and Infectious Diseases
Other Positions
Assistant Professor of Radiology
Radiology-Massachusetts General Hospital
Harvard Medical School
Links
Bibliography
Stereodivergent Complexity-to-Diversity Strategy en Route to the Synthesis of Nature-Inspired Skeleta.
Srinivasulu V, Srikanth G, Khanfar MA, Abu-Yousef IA, Majdalawieh AF, Mazitschek R, Setty SC, Sebastian A, Al-Tel TH.
J Org Chem. 2022 01 21. 87(2):1377-1397. PMID: 35014258
Bright and stable luminescent probes for target engagement profiling in live cells.
Payne NC, Kalyakina AS, Singh K, Tye MA, Mazitschek R.
Nat Chem Biol. 2021 11. 17(11):1168-1177. PMID: 34675420
Zinc-dependent histone deacetylases drive neutrophil extracellular trap formation and potentiate local and systemic inflammation.
Poli V, Pui-Yan Ma V, Di Gioia M, Broggi A, Benamar M, Chen Q, Mazitschek R, Haggarty SJ, Chatila TA, Karp JM, Zanoni I.
iScience. 2021 Nov 19. 24(11):103256. PMID: 34761180
Correction: HDAC6 inhibitor WT161 downregulates growth factor receptors in breast cancer.
Hideshima T, Mazitschek R, Qi J, Mimura N, Tseng JC, Kung AL, Bradner JE, Anderson KC.
Oncotarget. 2021 Aug 17. 12(17):1736. PMID: 34434504
Discovery of novel class of histone deacetylase inhibitors as potential anticancer agents.
El-Awady R, Saleh E, Hamoudi R, Ramadan WS, Mazitschek R, Nael MA, Elokely KM, Abou-Gharbia M, Childers WE, Srinivasulu V, Aloum L, Menon V, Al-Tel TH.
Bioorg Med Chem. 2021 07 15. 42:116251. PMID: 34116381
The Prolyl-tRNA Synthetase Inhibitor Halofuginone Inhibits SARS-CoV-2 Infection.
Sandoval DR, Clausen TM, Nora C, Cribbs AP, Denardo A, Clark AE, Garretson AF, Coker JKC, Narayanan A, Majowicz SA, Philpott M, Johansson C, Dunford JE, Spliid CB, Golden GJ, Payne NC, Tye MA, Nowell CJ, Griffis ER, Piermatteo A, Grunddal KV, Alle T, Magida JA, Hauser BM, Feldman J, Caradonna TM, Pu Y, Yin X, McVicar RN, Kwong EM, Weiss RJ, Downes M, Tsimikas S, Smidt AG, Ballatore C, Zengler K, Evans RM, Chanda SK, Croker BA, Leibel SL, Jose J, Mazitschek R, Oppermann U, Esko JD, Carlin AF, Gordts PLSM.
bioRxiv. 2021 Mar 26. PMID: 33791697
Antifungal Activity of Gepinacin Scaffold Glycosylphosphatidylinositol Anchor Biosynthesis Inhibitors with Improved Metabolic Stability.
Liston SD, Whitesell L, McLellan CA, Mazitschek R, Petraitis V, Petraitiene R, Kavaliauskas P, Walsh TJ, Cowen LE.
Antimicrob Agents Chemother. 2020 09 21. 64(10). PMID: 32661007
Rapid 'mix and read' assay for scalable detection of SARS-CoV-2 antibodies in patient plasma.
Yue H, Nowak RP, Overwijn D, Payne NC, Fischinger S, Atyeo C, Baden LR, Nilles EJ, Karlson EW, Yu XG, Li JZ, Alter G, Mazitschek R, Fischer ES.
medRxiv. 2020 Sep 03. PMID: 32909004
Obtusaquinone: A Cysteine-Modifying Compound That Targets Keap1 for Degradation.
Badr CE, da Hora CC, Kirov AB, Tabet E, Amante R, Maksoud S, Nibbs AE, Fitzsimons E, Boukhali M, Chen JW, Chiu NHL, Nakano I, Haas W, Mazitschek R, Tannous BA.
ACS Chem Biol. 2020 06 19. 15(6):1445-1454. PMID: 32338864