Ralph Mazitschek

Advances in malaria pharmacology and the online guide to MALARIA PHARMACOLOGY: IUPHAR review 38.

Armstrong JF, Campo B, Alexander SPH, Arendse LB, Cheng X, Davenport AP, Faccenda E, Fidock DA, Godinez-Macias KP, Harding SD, Kato N, Lee MCS, Luth MR, Mazitschek R, Mittal N, Niles JC, Okombo J, Ottilie S, Pasaje CFA, Probst AS, Rawat M, Rocamora F, Sakata-Kato T, Southan C, Spedding M, Tye MA, Yang T, Zhao N, Davies JA.

Br J Pharmacol. 2023 08. 180(15):1899-1929. PMID: 37197802

Oxycodone withdrawal induces HDAC1/HDAC2-dependent transcriptional maladaptations in the reward pathway in a mouse model of peripheral nerve injury.

Pryce KD, Serafini RA, Ramakrishnan A, Nicolais A, Giosan IM, Polizu C, Torres-Berrío A, Vuppala S, Kronman H, Ruiz A, Gaspari S, Peña CJ, Sakloth F, Mitsi V, van Duzer J, Mazitschek R, Jarpe M, Shen L, Nestler EJ, Zachariou V.

Nat Neurosci. 2023 07. 26(7):1229-1244. PMID: 37291337

Nitrilase mediated mild hydrolysis of a carbon-14 nitrile for the radiosynthesis of 4-(7-hydroxycarbamoyl-[1-14 C-heptanoyl]-oxy)-benzoic acid methyl ester, [14 C]-SHP-141: A novel class I/II histone deacetylase (HDAC) inhibitor.

Kitson SL, Watters W, Moody TS, Chappell T, Mazitschek R.

J Labelled Comp Radiopharm. 2023 06. 66(7-8):172-179. PMID: 37186406

Structural and biochemical characterization establishes a detailed understanding of KEAP1-CUL3 complex assembly.

Adamson RJ, Payne NC, Bartual SG, Mazitschek R, Bullock AN.

Free Radic Biol Med. 2023 08 01. 204:215-225. PMID: 37156295

Diagnostic TR-FRET assays for detection of antibodies in patient samples.

Yue H, Nowak RP, Overwijn D, Payne NC, Fischinger S, Atyeo C, Lam EC, St Denis K, Brais LK, Konishi Y, Sklavenitis-Pistofidis R, Baden LR, Nilles EJ, Karlson EW, Yu XG, Li JZ, Woolley AE, Ghobrial IM, Meyerhardt JA, Balazs AB, Alter G, Mazitschek R, Fischer ES.

Cell Rep Methods. 2023 Mar 27. 3(3):100421. PMID: 37056371

Correction: Prolyl-tRNA synthetase as a novel therapeutic target in multiple myeloma.

Kurata K, James-Bott A, Tye MA, Yamamoto L, Samur MK, Tai YT, Dunford J, Johansson C, Senbabaoglu F, Philpott M, Palmer C, Ramasamy K, Gooding S, Smilova M, Gaeta G, Guo M, Christianson JC, Payne NC, Singh K, Karagoz K, Stokes ME, Ortiz M, Hagner P, Thakurta A, Cribbs A, Mazitschek R, Hideshima T, Anderson KC, Oppermann U.

Blood Cancer J. 2023 Feb 07. 13(1):24. PMID: 36746923

Prolyl-tRNA synthetase as a novel therapeutic target in multiple myeloma.

Kurata K, James-Bott A, Tye MA, Yamamoto L, Samur MK, Tai YT, Dunford J, Johansson C, Senbabaoglu F, Philpott M, Palmer C, Ramasamy K, Gooding S, Smilova M, Gaeta G, Guo M, Christianson JC, Payne NC, Singh K, Karagoz K, Stokes ME, Ortiz M, Hagner P, Thakurta A, Cribbs A, Mazitschek R, Hideshima T, Anderson KC, Oppermann U.

Blood Cancer J. 2023 01 12. 13(1):12. PMID: 36631435

Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance.

Tye MA, Payne NC, Johansson C, Singh K, Santos SA, Fagbami L, Pant A, Sylvester K, Luth MR, Marques S, Whitman M, Mota MM, Winzeler EA, Lukens AK, Derbyshire ER, Oppermann U, Wirth DF, Mazitschek R.

Nat Commun. 2022 08 25. 13(1):4976. PMID: 36008486

A direct high-throughput protein quantification strategy facilitates discovery and characterization of a celastrol-derived BRD4 degrader.

Payne NC, Maksoud S, Tannous BA, Mazitschek R.

Cell Chem Biol. 2022 08 18. 29(8):1333-1340.e5. PMID: 35649410

Resolving the deceptive isoform and complex selectivity of HDAC1/2 inhibitors.

Payne NC, Mazitschek R.

Cell Chem Biol. 2022 07 21. 29(7):1140-1152.e5. PMID: 35298895