Robert Leon Summers

Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation.

Bopp S, Pasaje CFA, Summers RL, Magistrado-Coxen P, Schindler KA, Corpas-Lopez V, Yeo T, Mok S, Dey S, Smick S, Nasamu AS, Demas AR, Milne R, Wiedemar N, Corey V, Gomez-Lorenzo MG, Franco V, Early AM, Lukens AK, Milner D, Furtado J, Gamo FJ, Winzeler EA, Volkman SK, Duffey M, Laleu B, Fidock DA, Wyllie S, Niles JC, Wirth DF.

Nat Commun. 2023 03 16. 14(1):1455. PMID: 36927839

Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention.

Summers RL, Pasaje CFA, Pisco JP, Striepen J, Luth MR, Kumpornsin K, Carpenter EF, Munro JT, Plater A, Punekar AS, Shepherd AM, Shepherd SM, Vanaerschot M, Murithi JM, Rubiano K, Akidil A, Ottilie S, Mittal N, Dilmore AH, Won M, Mandt REK, McGowen K, Owen E, Walpole C, Llinás M, Lee MCS, Winzeler EA, Fidock DA, Gilbert IH, Wirth DF, Niles JC, Baragaña B, Lukens AK.

Cell Chem Biol. 2022 02 17. 29(2):191-201.e8. PMID: 34348113

Synthesis and biological evaluation of benzhydryl-based antiplasmodial agents possessing Plasmodium falciparum chloroquine resistance transporter (PfCRT) inhibitory activity.

Relitti N, Federico S, Pozzetti L, Butini S, Lamponi S, Taramelli D, D'Alessandro S, Martin RE, Shafik SH, Summers RL, Babij SK, Habluetzel A, Tapanelli S, Caldelari R, Gemma S, Campiani G.

Eur J Med Chem. 2021 Apr 05. 215:113227. PMID: 33601312

Inferring a complete genotype-phenotype map from a small number of measured phenotypes.

Sailer ZR, Shafik SH, Summers RL, Joule A, Patterson-Robert A, Martin RE, Harms MJ.

PLoS Comput Biol. 2020 09. 16(9):e1008243. PMID: 32991585

The natural function of the malaria parasite's chloroquine resistance transporter.

Shafik SH, Cobbold SA, Barkat K, Richards SN, Lancaster NS, Llinás M, Hogg SJ, Summers RL, McConville MJ, Martin RE.

Nat Commun. 2020 08 06. 11(1):3922. PMID: 32764664

Biochemical characterization and chemical inhibition of PfATP4-associated Na+-ATPase activity in Plasmodium falciparum membranes.

Rosling JEO, Ridgway MC, Summers RL, Kirk K, Lehane AM.

J Biol Chem. 2018 08 24. 293(34):13327-13337. PMID: 29986883

Verapamil-Sensitive Transport of Quinacrine and Methylene Blue via the Plasmodium falciparum Chloroquine Resistance Transporter Reduces the Parasite's Susceptibility to these Tricyclic Drugs.

van Schalkwyk DA, Nash MN, Shafik SH, Summers RL, Lehane AM, Smith PJ, Martin RE.

J Infect Dis. 2016 Mar 01. 213(5):800-10. PMID: 26503982

1H-NMR metabolite profiles of different strains of Plasmodium falciparum.

Teng R, Lehane AM, Winterberg M, Shafik SH, Summers RL, Martin RE, van Schalkwyk DA, Junankar PR, Kirk K.

Biosci Rep. 2014 Nov 21. 34(6):e00150. PMID: 25405893

Multiple drugs compete for transport via the Plasmodium falciparum chloroquine resistance transporter at distinct but interdependent sites.

Bellanca S, Summers RL, Meyrath M, Dave A, Nash MN, Dittmer M, Sanchez CP, Stein WD, Martin RE, Lanzer M.

J Biol Chem. 2014 Dec 26. 289(52):36336-51. PMID: 25378409

Diverse mutational pathways converge on saturable chloroquine transport via the malaria parasite's chloroquine resistance transporter.

Summers RL, Dave A, Dolstra TJ, Bellanca S, Marchetti RV, Nash MN, Richards SN, Goh V, Schenk RL, Stein WD, Kirk K, Sanchez CP, Lanzer M, Martin RE.

Proc Natl Acad Sci U S A. 2014 Apr 29. 111(17):E1759-67. PMID: 24728833