John LaPorte Given Professor of Immunology and Infectious Diseases
Immunology and Infectious Diseases
Chair, Department of Immunology and Infectious Diseases
Immunology and Infectious Diseases
Harvard T.H. Chan School of Public Health
My laboratory focuses on the molecular basis of population heterogeneity in Mycobacterium tuberculosis (Mtb) and the extent to which differences between mycobacterial cells contribute to differences in disease and treatment outcomes. Our work combines bacterial genetic approaches with high throughput methodologies including population genomics, ssRNAseq and quantitative live cell imaging to define the molecular mechanisms by which Mtb generates diversity and how this diversity enables the bacterium to survive subsequent selective forces including antibiotics and immune selection. We further seek to understand the impact of host immune responses on the interaction of Mtb with the infected host, again working at both single cell and genomic levels. My work engages a broad network of collaborators including experts in technologies to assess single cell behavior at MIT and MGH, experts in sequencing methodologies at the Broad Institute and experts in human immunology at the Ragon Institute, where I am the outgoing Director of the TB Program.
B.S., 1990, Biology
Yale University
M.D., 1996, Medicine
Columbia University, College of Physicians and Surgeons
2000, 3years Internship/Residency in Internal Medicine
Brigham and Women’s Hospital
2001, 1year Clinical Fellowship in Infectious Diseases
Brigham and Women’s Hospital
Post Doc, 2006, Immunology & Infectious Diseases - 5years Postdoctoral Fellow
HSPH
Junior Faculty Mentoring Award
Harvard School of Public Health
John LaPorte Given Professor
Harvard School of Public Health
Alice B. Hamilton Award
Harvard School of Public Health
Investigator in the Pathogenesis of Infectious Diseases
Burroughs Welcome Foundation
Melvin and Geraldine Glimcher Associate Professorship
Harvard School of Public Health
Science and Public Leadership Fellow
PopTech
Clinical Scientist Development Award
Doris Duke
Early Career Award
Hood Foundation
Early Career Award
Howard Hughes Medical Institute
New Innovator Award
National Institute of Health
The Maxwell Finland Award for Excellence in Research
Mass. Infectious Disease Society
The Maxwell Finland Award for Excellence in Research, Mass. Infectious Disease Society
The National Foundation for Infectious Diseases
Teaching Award for Residents in Internal Medicine
Harvard Medical School
Alpha Omega Alpha
Phi Beta Kappa
Medical Student Fellowship for Return to Medical Studies
Howard Hughes Medical Institute
Medical Student Research Fellowship
Howard Hughes Medical Institute
B.S. Summa Cum Laude
Yale
Community Service Award
Yale
Winchell CG, Nyquist SK, Chao MC, Maiello P, Myers AJ, Hopkins F, Chase M, Gideon HP, Patel KV, Bromley JD, Simonson AW, Floyd-O'Sullivan R, Wadsworth M, Rosenberg JM, Uddin R, Hughes T, Kelly RJ, Griffo J, Tomko J, Klein E, Berger B, Scanga CA, Mattila J, Fortune SM, Shalek AK, Lin PL, Flynn JL.
J Exp Med. 2023 12 04. 220(12). PMID: 37843832
Stanley S, Wang X, Liu Q, Kwon YY, Frey AM, Hicks ND, Vickers AJ, Hui S, Fortune SM.
bioRxiv. 2023 Oct 09. PMID: 37873410
Zhou Y, Sun H, Rapiejko AR, Vargas-Blanco DA, Martini MC, Chase MR, Joubran SR, Davis AB, Dainis JP, Kelly JM, Ioerger TR, Roberts LA, Fortune SM, Shell SS.
J Biol Chem. 2023 Oct 05. 299(11):105312. PMID: 37802316
Bei C, Zhu J, Culviner PH, Rubin EJ, Fortune SM, Gao Q, Liu Q.
Res Sq. 2023 Sep 18. PMID: 37790329
Bei C, Zhu J, Culviner PH, Rubin EJ, Fortune SM, Gao Q, Liu Q.
bioRxiv. 2023 Aug 20. PMID: 37645742
Irvine EB, Darrah PA, Wang S, Wang C, McNamara RP, Roederer M, Seder RA, Lauffenburger DA, Flynn JL, Fortune SM, Alter G.
bioRxiv. 2023 Aug 02. PMID: 37577655
Peters JM, Irvine EB, Rosenberg JM, Wadsworth MH, Hughes TK, Sutton M, Nyquist SK, Bromley JD, Mondal R, Roederer M, Seder RA, Darrah PA, Alter G, Flynn JL, Shalek AK, Fortune SM, Bryson BD.
bioRxiv. 2023 Jul 18. PMID: 37502895
Davies LRL, Smith MT, Cizmeci D, Fischinger S, Shih-Lu Lee J, Lu LL, Layton ED, Grant AD, Fielding K, Stein CM, Boom WH, Hawn TR, Fortune SM, Wallis RS, Churchyard GJ, Alter G, Seshadri C.
EBioMedicine. 2023 Jul. 93:104678. PMID: 37379655
Darrah PA, Zeppa JJ, Wang C, Irvine EB, Bucsan AN, Rodgers MA, Pokkali S, Hackney JA, Kamath M, White AG, Borish HJ, Frye LJ, Tomko J, Kracinovsky K, Lin PL, Klein E, Scanga CA, Alter G, Fortune SM, Lauffenburger DA, Flynn JL, Seder RA, Maiello P, Roederer M.
Cell Host Microbe. 2023 Jun 14. 31(6):962-977.e8. PMID: 37267955
Nziza N, Jung W, Mendu M, Chen T, McNamara RP, Fortune SM, Franken KLMC, Ottenhoff THM, Bryson B, Ngonzi J, Bebell LM, Alter G.
Front Microbiol. 2023. 14:1171990. PMID: 37228375
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