My laboratory focuses on the molecular basis of population heterogeneity in Mycobacterium tuberculosis (Mtb) and the extent to which differences between mycobacterial cells contribute to differences in disease and treatment outcomes. Our work combines bacterial genetic approaches with high throughput methodologies including population genomics, ssRNAseq and quantitative live cell imaging to define the molecular mechanisms by which Mtb generates diversity and how this diversity enables the bacterium to survive subsequent selective forces including antibiotics and immune selection. We further seek to understand the impact of host immune responses on the interaction of Mtb with the infected host, again working at both single cell and genomic levels. My work engages a broad network of collaborators including experts in technologies to assess single cell behavior at MIT and MGH, experts in sequencing methodologies at the Broad Institute and experts in human immunology at the Ragon Institute, where I am the outgoing Director of the TB Program.
B.S., 1990, Biology
Yale University
M.D., 1996, Medicine
Columbia University, College of Physicians and Surgeons
2000, 3years Internship/Residency in Internal Medicine
Brigham and Women’s Hospital
2001, 1year Clinical Fellowship in Infectious Diseases
Brigham and Women’s Hospital
Post Doc, 2006, Immunology & Infectious Diseases - 5years Postdoctoral Fellow
HSPH
Junior Faculty Mentoring Award2019-2020
Harvard School of Public Health
John LaPorte Given Professor 2017
Harvard School of Public Health
Alice B. Hamilton Award2013
Harvard School of Public Health
Investigator in the Pathogenesis of Infectious Diseases2012
Burroughs Welcome Foundation
Melvin and Geraldine Glimcher Associate Professorship2012
Harvard School of Public Health
Science and Public Leadership Fellow2010
PopTech
Clinical Scientist Development Award2010
Doris Duke
Early Career Award2007
Hood Foundation
Early Career Award2007
Howard Hughes Medical Institute
New Innovator Award2007
National Institute of Health
The Maxwell Finland Award for Excellence in Research2004
Mass. Infectious Disease Society
The Maxwell Finland Award for Excellence in Research, Mass. Infectious Disease Society2004
The National Foundation for Infectious Diseases
Teaching Award for Residents in Internal Medicine2001
Harvard Medical School
Alpha Omega Alpha1996
Phi Beta Kappa1993
Medical Student Fellowship for Return to Medical Studies1993
Howard Hughes Medical Institute
Medical Student Research Fellowship1993
Howard Hughes Medical Institute
B.S. Summa Cum Laude1990
Yale
Community Service Award1989
Yale