John LaPorte Given Professor of Immunology and Infectious Diseases
Immunology and Infectious Diseases
Chair, Department of Immunology and Infectious Diseases
Immunology and Infectious Diseases
Harvard T.H. Chan School of Public Health
My laboratory focuses on the molecular basis of population heterogeneity in Mycobacterium tuberculosis (Mtb) and the extent to which differences between mycobacterial cells contribute to differences in disease and treatment outcomes. Our work combines bacterial genetic approaches with high throughput methodologies including population genomics, ssRNAseq and quantitative live cell imaging to define the molecular mechanisms by which Mtb generates diversity and how this diversity enables the bacterium to survive subsequent selective forces including antibiotics and immune selection. We further seek to understand the impact of host immune responses on the interaction of Mtb with the infected host, again working at both single cell and genomic levels. My work engages a broad network of collaborators including experts in technologies to assess single cell behavior at MIT and MGH, experts in sequencing methodologies at the Broad Institute and experts in human immunology at the Ragon Institute, where I am the outgoing Director of the TB Program.
B.S., 1990, Biology
Yale University
M.D., 1996, Medicine
Columbia University, College of Physicians and Surgeons
2000, 3years Internship/Residency in Internal Medicine
Brigham and Women’s Hospital
2001, 1year Clinical Fellowship in Infectious Diseases
Brigham and Women’s Hospital
Post Doc, 2006, Immunology & Infectious Diseases - 5years Postdoctoral Fellow
HSPH
Community Service Award
Yale
B.S. Summa Cum Laude
Yale
Phi Beta Kappa
Medical Student Fellowship for Return to Medical Studies
Howard Hughes Medical Institute
Medical Student Research Fellowship
Howard Hughes Medical Institute
Alpha Omega Alpha
Teaching Award for Residents in Internal Medicine
Harvard Medical School
The Maxwell Finland Award for Excellence in Research
Mass. Infectious Disease Society
The Maxwell Finland Award for Excellence in Research, Mass. Infectious Disease Society
The National Foundation for Infectious Diseases
Early Career Award
Hood Foundation
Early Career Award
Howard Hughes Medical Institute
New Innovator Award
National Institute of Health
Science and Public Leadership Fellow
PopTech
Clinical Scientist Development Award
Doris Duke
Investigator in the Pathogenesis of Infectious Diseases
Burroughs Welcome Foundation
Melvin and Geraldine Glimcher Associate Professorship
Harvard School of Public Health
Alice B. Hamilton Award
Harvard School of Public Health
John LaPorte Given Professor
Harvard School of Public Health
Junior Faculty Mentoring Award
Harvard School of Public Health
Peters JM, Irvine EB, Rosenberg JM, Wadsworth MH, Hughes TK, Sutton M, Nyquist SK, Bromley JD, Mondal R, Roederer M, Seder RA, Darrah PA, Alter G, Flynn JL, Shalek AK, Fortune SM, Bryson BD.
bioRxiv. 2023 Jul 18. PMID: 37502895
Davies LRL, Smith MT, Cizmeci D, Fischinger S, Shih-Lu Lee J, Lu LL, Layton ED, Grant AD, Fielding K, Stein CM, Boom WH, Hawn TR, Fortune SM, Wallis RS, Churchyard GJ, Alter G, Seshadri C.
EBioMedicine. 2023 Jul. 93:104678. PMID: 37379655
Darrah PA, Zeppa JJ, Wang C, Irvine EB, Bucsan AN, Rodgers MA, Pokkali S, Hackney JA, Kamath M, White AG, Borish HJ, Frye LJ, Tomko J, Kracinovsky K, Lin PL, Klein E, Scanga CA, Alter G, Fortune SM, Lauffenburger DA, Flynn JL, Seder RA, Maiello P, Roederer M.
Cell Host Microbe. 2023 Jun 14. 31(6):962-977.e8. PMID: 37267955
Nziza N, Jung W, Mendu M, Chen T, McNamara RP, Fortune SM, Franken KLMC, Ottenhoff THM, Bryson B, Ngonzi J, Bebell LM, Alter G.
Front Microbiol. 2023. 14:1171990. PMID: 37228375
Stanley S, Spaulding CN, Liu Q, Chase MR, Ha DTM, Thai PVK, Lan NH, Thu DDA, Quang NL, Brown J, Hicks ND, Wang X, Marin M, Howard NC, Vickers AJ, Karpinski WM, Chao MC, Farhat MR, Caws M, Dunstan SJ, Thuong NTT, Fortune SM.
bioRxiv. 2023 Apr 10. PMID: 37090677
Bedard M, van der Niet S, Bernard EM, Babunovic G, Cheng TY, Aylan B, Grootemaat AE, Raman S, Botella L, Ishikawa E, O'Sullivan MP, O'Leary S, Mayfield JA, Buter J, Minnaard AJ, Fortune SM, Murphy LO, Ory DS, Keane J, Yamasaki S, Gutierrez MG, van der Wel N, Moody DB.
J Clin Invest. 2023 03 15. 133(6). PMID: 36757797
Gordon SB, Sichone S, Chirwa AE, Hazenberg P, Kafuko Z, Ferreira DM, Flynn J, Fortune S, Balasingam S, Biagini GA, McShane H, Mwandumba H, Jambo K, Dedha K, Raj Sharma N, Robertson BD, Walker N, Morton B.
Wellcome Open Res. 2023. 8:71. PMID: 37007907
Zhu J, Liu YJ, Fortune SM.
Curr Opin Microbiol. 2023 04. 72:102266. PMID: 36745965
Liu Q, Zhu J, Dulberger CL, Stanley S, Wilson S, Chung ES, Wang X, Culviner P, Liu YJ, Hicks ND, Babunovic GH, Giffen SR, Aldridge BB, Garner EC, Rubin EJ, Chao MC, Fortune SM.
Science. 2022 12 09. 378(6624):1111-1118. PMID: 36480634
Freeman AH, Tembiwa K, Brenner JR, Chase MR, Fortune SM, Morita YS, Boutte CC.
Mol Microbiol. 2023 02. 119(2):208-223. PMID: 36416406
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