Cutting Edge: The Use of Topical Aminoglycosides as an Effective Pull in "Prime and Pull" Vaccine Strategy.
Gopinath S, Lu P, Iwasaki A.
J Immunol. 2020 04 01. 204(7):1703-1707. PMID: 32122994
Assistant Professor of Immunology and Infectious Diseases
Immunology and Infectious Diseases
We are interested in studying the interactions between the commensal microbiota, pathogens and the host immune response in the one place they must necessarily meet – the mucosa. Studying host-pathogen interactions at the mucosa allows us to exploit the Red Queen Hypothesis (co-evolving organisms locked in competition) as a discovery tool to identify novel pathways and mechanisms by which we resist or tolerate infections. We have multiple projects aimed at studying the mechanisms by which pathogens activate and evade the mucosal immune response and how these interactions are modulated by the microbiota. Our goal is to generate and test new ideas for vaccine and drug candidates to better protect people against infectious disease.
B.A., 2006, Biology, English
Mount Holyoke College, South Hadley, MA
PhD, 2013, Microbiolgy & Immunology
Stanford University, Stanford, CA
2020, Viral Host-Pathogenesis
Yale University, New Haven, CT
Gopinath S, Lu P, Iwasaki A.
J Immunol. 2020 04 01. 204(7):1703-1707. PMID: 32122994
Gopinath S, Kim MV, Rakib T, Wong PW, van Zandt M, Barry NA, Kaisho T, Goodman AL, Iwasaki A.
Nat Microbiol. 2018 05. 3(5):611-621. PMID: 29632368
Chernyavskaya Y, Mudbhary R, Zhang C, Tokarz D, Jacob V, Gopinath S, Sun X, Wang S, Magnani E, Madakashira BP, Yoder JA, Hoshida Y, Sadler KC.
Development. 2017 08 15. 144(16):2925-2939. PMID: 28698226
Shin H, Kumamoto Y, Gopinath S, Iwasaki A.
Nat Commun. 2016 11 09. 7:13346. PMID: 27827367
Gopinath S, Kumamoto Y, Iwasaki A.
Nat Immunol. 2016 Feb. 17(2):119-20. PMID: 26784258
Hotson AN, Gopinath S, Nicolau M, Khasanova A, Finck R, Monack D, Nolan GP.
Sci Signal. 2016 Jan 12. 9(410):ra4. PMID: 26758212
Gopinath S, Iwasaki A.
Immunity. 2015 May 19. 42(5):790-1. PMID: 25992855
Gopinath S, Lichtman JS, Bouley DM, Elias JE, Monack DM.
Proc Natl Acad Sci U S A. 2014 Nov 04. 111(44):15780-5. PMID: 25331868
Ng KM, Ferreyra JA, Higginbottom SK, Lynch JB, Kashyap PC, Gopinath S, Naidu N, Choudhury B, Weimer BC, Monack DM, Sonnenburg JL.
Nature. 2013 Oct 03. 502(7469):96-9. PMID: 23995682
Gopinath S, Hotson A, Johns J, Nolan G, Monack D.
PLoS Pathog. 2013. 9(6):e1003408. PMID: 23754944