Sudha Biddinger

Gut Microbiota-Derived Trimethylamine N-Oxide Contributes to Abdominal Aortic Aneurysm Through Inflammatory and Apoptotic Mechanisms.

Benson TW, Conrad KA, Li XS, Wang Z, Helsley RN, Schugar RC, Coughlin TM, Wadding-Lee C, Fleifil S, Russell HM, Stone T, Brooks M, Buffa JA, Mani K, Björck M, Wanhainen A, Sangwan N, Biddinger S, Bhandari R, Ademoya A, Pascual C, Tang WHW, Tranter M, Cameron SJ, Brown JM, Hazen SL, Owens AP.

Circulation. 2023 04 04. 147(14):1079-1096. PMID: 37011073

Inhibition of nonalcoholic fatty liver disease in mice by selective inhibition of mTORC1.

Gosis BS, Wada S, Thorsheim C, Li K, Jung S, Rhoades JH, Yang Y, Brandimarto J, Li L, Uehara K, Jang C, Lanza M, Sanford NB, Bornstein MR, Jeong S, Titchenell PM, Biddinger SB, Arany Z.

Science. 2022 04 15. 376(6590):eabf8271. PMID: 35420934

Evaluating human genetic support for hypothesized metabolic disease genes.

Dornbos P, Singh P, Jang DK, Mahajan A, Biddinger SB, Rotter JI, McCarthy MI, Flannick J.

Cell Metab. 2022 05 03. 34(5):661-666. PMID: 35421386

Insulin Prevents Hypercholesterolemia by Suppressing 12a-Hydroxylated Bile Acids.

Semova I, Levenson AE, Krawczyk J, Bullock K, Gearing ME, Ling AV, Williams KA, Miao J, Adamson SS, Shin DJ, Chahar S, Graham MJ, Crooke RM, Hagey LR, Vicent D, de Ferranti SD, Kidambi S, Clish CB, Biddinger SB.

Circulation. 2022 03 29. 145(13):969-982. PMID: 35193378

Triglycerides in Nonalcoholic Fatty Liver Disease: Guilty Until Proven Innocent.

Semova I, Biddinger SB.

Trends Pharmacol Sci. 2021 03. 42(3):183-190. PMID: 33468321

Markers of cholesterol synthesis are elevated in adolescents and young adults with type 2 diabetes.

Semova I, Levenson AE, Krawczyk J, Bullock K, Williams KA, Wadwa RP, Khoury PR, Kimball TR, Urbina EM, de Ferranti SD, Maahs DM, Dolan LM, Shah AS, Clish CB, Biddinger SB.

Pediatr Diabetes. 2020 11. 21(7):1126-1131. PMID: 32738021

Type 1 diabetes is associated with an increase in cholesterol absorption markers but a decrease in cholesterol synthesis markers in a young adult population.

Semova I, Levenson AE, Krawczyk J, Bullock K, Williams KA, Wadwa RP, Shah AS, Khoury PR, Kimball TR, Urbina EM, de Ferranti SD, Bishop FK, Maahs DM, Dolan LM, Clish CB, Biddinger SB.

J Clin Lipidol. 2019 Nov - Dec. 13(6):940-946. PMID: 31706902

Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction.

Chen S, Henderson A, Petriello MC, Romano KA, Gearing M, Miao J, Schell M, Sandoval-Espinola WJ, Tao J, Sha B, Graham M, Crooke R, Kleinridders A, Balskus EP, Rey FE, Morris AJ, Biddinger SB.

Cell Metab. 2019 12 03. 30(6):1141-1151.e5. PMID: 31543404

Acute suppression of insulin resistance-associated hepatic miR-29 in vivo improves glycemic control in adult mice.

Hung YH, Kanke M, Kurtz CL, Cubitt R, Bunaciu RP, Miao J, Zhou L, Graham JL, Hussain MM, Havel P, Biddinger S, White PJ, Sethupathy P.

Physiol Genomics. 2019 08 01. 51(8):379-389. PMID: 31251698

microRNA-146a-5p association with the cardiometabolic disease risk factor TMAO.

Coffey AR, Kanke M, Smallwood TL, Albright J, Pitman W, Gharaibeh RZ, Hua K, Gertz E, Biddinger SB, Temel RE, Pomp D, Sethupathy P, Bennett BJ.

Physiol Genomics. 2019 02 01. 51(2):59-71. PMID: 30633643