Triglycerides in Nonalcoholic Fatty Liver Disease: Guilty Until Proven Innocent.
Semova I, Biddinger SB.
Trends Pharmacol Sci. 2021 03. 42(3):183-190. PMID: 33468321
Secondary Faculty
Sudha Biddinger
Associate Professor in the Department of Molecular Metabolism
Molecular Metabolism
Other Positions
Associate Professor of Pediatrics
Pediatrics-Boston Children's Hospital
Harvard Medical School
Links
Bibliography
Markers of cholesterol synthesis are elevated in adolescents and young adults with type 2 diabetes.
Semova I, Levenson AE, Krawczyk J, Bullock K, Williams KA, Wadwa RP, Khoury PR, Kimball TR, Urbina EM, de Ferranti SD, Maahs DM, Dolan LM, Shah AS, Clish CB, Biddinger SB.
Pediatr Diabetes. 2020 11. 21(7):1126-1131. PMID: 32738021
Type 1 diabetes is associated with an increase in cholesterol absorption markers but a decrease in cholesterol synthesis markers in a young adult population.
Semova I, Levenson AE, Krawczyk J, Bullock K, Williams KA, Wadwa RP, Shah AS, Khoury PR, Kimball TR, Urbina EM, de Ferranti SD, Bishop FK, Maahs DM, Dolan LM, Clish CB, Biddinger SB.
J Clin Lipidol. 2019 Nov - Dec. 13(6):940-946. PMID: 31706902
Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction.
Chen S, Henderson A, Petriello MC, Romano KA, Gearing M, Miao J, Schell M, Sandoval-Espinola WJ, Tao J, Sha B, Graham M, Crooke R, Kleinridders A, Balskus EP, Rey FE, Morris AJ, Biddinger SB.
Cell Metab. 2019 12 03. 30(6):1141-1151.e5. PMID: 31543404
Acute suppression of insulin resistance-associated hepatic miR-29 in vivo improves glycemic control in adult mice.
Hung YH, Kanke M, Kurtz CL, Cubitt R, Bunaciu RP, Miao J, Zhou L, Graham JL, Hussain MM, Havel P, Biddinger S, White PJ, Sethupathy P.
Physiol Genomics. 2019 08 01. 51(8):379-389. PMID: 31251698
microRNA-146a-5p association with the cardiometabolic disease risk factor TMAO.
Coffey AR, Kanke M, Smallwood TL, Albright J, Pitman W, Gharaibeh RZ, Hua K, Gertz E, Biddinger SB, Temel RE, Pomp D, Sethupathy P, Bennett BJ.
Physiol Genomics. 2019 02 01. 51(2):59-71. PMID: 30633643
The beta secretase BACE1 regulates the expression of insulin receptor in the liver.
Meakin PJ, Mezzapesa A, Benabou E, Haas ME, Bonardo B, Grino M, Brunel JM, Desbois-Mouthon C, Biddinger SB, Govers R, Ashford MLJ, Peiretti F.
Nat Commun. 2018 04 03. 9(1):1306. PMID: 29610518
FoxO1 Is Required for Most of the Metabolic and Hormonal Perturbations Produced by Hepatic Insulin Receptor Deletion in Male Mice.
Ling AV, Gearing ME, Semova I, Shin DJ, Clements R, Lai ZW, Biddinger SB.
Endocrinology. 2018 03 01. 159(3):1253-1263. PMID: 29300910
Nonalcoholic fatty liver disease and gastric bypass surgery regulate serum and hepatic levels of pyruvate kinase isoenzyme M2.
Meoli L, Gupta NK, Saeidi N, Panciotti CA, Biddinger SB, Corey KE, Stylopoulos N.
Am J Physiol Endocrinol Metab. 2018 10 01. 315(4):E613-E621. PMID: 29462566
Fructose and glucose can regulate mammalian target of rapamycin complex 1 and lipogenic gene expression via distinct pathways.
Hu Y, Semova I, Sun X, Kang H, Chahar S, Hollenberg AN, Masson D, Hirschey MD, Miao J, Biddinger SB.
J Biol Chem. 2018 02 09. 293(6):2006-2014. PMID: 29222328