Tamar Sofer
Assistant Professor

Tamar Sofer

Assistant Professor in the Department of Biostatistics

Biostatistics

tsofer@bwh.harvard.edu

Other Positions

Assistant Professor of Medicine

Medicine

Brigham and Women's Hospital


Overview

I am a biostatistical researcher focusing on genetic and omics analyses of diverse and complex populations. I did my PhD in Biostatistics at the Harvard T.H. Chan School of Public Health, and graduated at 2012. Then, I continued as a postdoctoral fellow there, and later became a research scientist at the Genetic Analysis Center at the University of Washington in Seattle. At UW, I worked on genetic association analyses in the Hispanic Community Health Study/Study of Latinos, and on analysis of whole genome sequencing data from the NHLBI's Trans-Omics in Precision Medicine initiative. In late 2017 I moved to BWH and Harvard University, where I continue to develop and implement methodology for genetic and omics analyses of sleep , cognitive, cardiopulmonary, and metabolic phenotypes, with the goal of understanding the genetic basis of such phenotypes, and how environmental exposures modify the pathways from genotypes to phenotypes. I extensively collaborate with minority population studies such as the Hispanic Community Health Study/Study of Latinos, the Multi-Ethnic Study of Atherosclerosis, the Jackson Heart Study, and more.

BSc, 03/2008, Mathematics
The Hebrew University of Jerusalem

PhD, 05/2012, Biostatistics
Harvard University


Bibliography

Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL.

Justice AE, Young K, Gogarten SM, Sofer T, Graff M, Love SAM, Wang Y, Klimentidis YC, Cruz M, Guo X, Hartwig F, Petty L, Yao J, Allison MA, Below JE, Buchanan TA, Chen YI, Goodarzi MO, Hanis C, Highland HM, Hsueh WA, Ipp E, Parra E, Palmas W, Raffel LJ, Rotter JI, Tan J, Taylor KD, Valladares A, Xiang AH, Sánchez-Johnsen L, Isasi CR, North KE.

Hum Mol Genet. 2021 Nov 01. 30(22):2190-2204. PMID: 34165540

Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program.

Cade BE, Lee J, Sofer T, Wang H, Zhang M, Chen H, Gharib SA, Gottlieb DJ, Guo X, Lane JM, Liang J, Lin X, Mei H, Patel SR, Purcell SM, Saxena R, Shah NA, Evans DS, Hanis CL, Hillman DR, Mukherjee S, Palmer LJ, Stone KL, Tranah GJ, Abecasis GR, Boerwinkle EA, Correa A, Cupples LA, Kaplan RC, Nickerson DA, North KE, Psaty BM, Rotter JI, Rich SS, Tracy RP, Vasan RS, Wilson JG, Zhu X, Redline S.

Genome Med. 2021 Aug 26. 13(1):136. PMID: 34446064

BinomiRare: A robust test for association of a rare genetic variant with a binary outcome for mixed models and any case-control proportion.

Sofer T, Lee J, Kurniansyah N, Jain D, Laurie CA, Gogarten SM, Conomos MP, Heavner B, Hu Y, Kooperberg C, Haessler J, Vasan RS, Cupples LA, Coombes BJ, Seyerle A, Gharib SA, Chen H, O'Connell JR, Zhang M, Gottlieb DJ, Psaty BM, Longstreth WT, Rotter JI, Taylor KD, Rich SS, Guo X, Boerwinkle E, Morrison AC, Pankow JS, Johnson AD, Pankratz N, Reiner AP, Redline S, Smith NL, Rice KM, Schifano ED.

HGG Adv. 2021 Jul 08. 2(3). PMID: 34337551