Replicative fitness costs of nonnucleoside reverse transcriptase inhibitor drug resistance mutations on HIV subtype C.
Armstrong KL, Lee TH, Essex M.
Antimicrob Agents Chemother. 2011 May. 55(5):2146-53. PMID: 21402856
Emeritus Faculty
Tun-hou Lee
Links
Overview
Research
Professor Lee's major research interests are virus-specific antigens and their association with disease manifestations, viral replication, and host-virus interactions, with particular focus on human and related primate retroviruses.
Currently, Professor Lee is focusing on the modification of the antigenicity of HIV envelope protein for vaccine development. His work has contributed to the development of serologic testing for the human leukemia virus (HTLV-I) and HIV. He was the first to identify the envelope gene products of HTLV-I, HTLV-II and HIV, and demonstrated that the envelope antibody is the most important marker for screening individuals for infection with the human retroviruses. This information became the basis for serologic tests for blood bank screening. He also identified the putative transforming protein of HTLV-I, which was also the first observation of a retrovirus protein linked to a cancer that was not an oncogene product.
Professor Lee has also worked to identify the immune response to HIV envelope protein and outcome of human immunodeficiency virus infection. His work on HIV envelope protein revealed that an association exists between progress to AIDS and the lack of certain envelope antibodies. Professor Lee has been a recipient of the junior investigator award from the Leukemia Society of America and the Swedish Medical Research Council postdoctoral fellowship award.
B.P.H, 1976
National Taiwan University
S.M., 1978
Harvard School of Public Health
D.Sc., 1982
Harvard School of Public Health
Bibliography
Conserved determinants of enhanced CCR5 binding in the human immunodeficiency virus subtype D envelope third variable loop.
Teeravechyan S, Essex M, Lee TH.
AIDS Res Hum Retroviruses. 2010 Apr. 26(4):481-8. PMID: 20377425
Replicative capacity differences of thymidine analog resistance mutations in subtype B and C human immunodeficiency virus type 1.
Armstrong KL, Lee TH, Essex M.
J Virol. 2009 May. 83(9):4051-9. PMID: 19225005
Estimating the lost benefits of antiretroviral drug use in South Africa.
Chigwedere P, Seage GR, Gruskin S, Lee TH, Essex M.
J Acquir Immune Defic Syndr. 2008 Dec 01. 49(4):410-5. PMID: 19186354
Efficacy of antiretroviral drugs in reducing mother-to-child transmission of HIV in Africa: a meta-analysis of published clinical trials.
Chigwedere P, Seage GR, Lee TH, Essex M.
AIDS Res Hum Retroviruses. 2008 Jun. 24(6):827-37. PMID: 18544018
Relative concordance of human immunodeficiency virus oligomeric and monomeric envelope in CCR5 coreceptor usage.
Teeravechyan S, Suphaphiphat P, Essex M, Lee TH.
Virology. 2008 Jan 20. 370(2):443-50. PMID: 17936869
Mutations in the V3 stem versus the V3 crown and C4 region have different effects on the binding and fusion steps of human immunodeficiency virus type 1 gp120 interaction with the CCR5 coreceptor.
Suphaphiphat P, Essex M, Lee TH.
Virology. 2007 Mar 30. 360(1):182-90. PMID: 17101166
Breastfeeding plus infant zidovudine prophylaxis for 6 months vs formula feeding plus infant zidovudine for 1 month to reduce mother-to-child HIV transmission in Botswana: a randomized trial: the Mashi Study.
Thior I, Lockman S, Smeaton LM, Shapiro RL, Wester C, Heymann SJ, Gilbert PB, Stevens L, Peter T, Kim S, van Widenfelt E, Moffat C, Ndase P, Arimi P, Kebaabetswe P, Mazonde P, Makhema J, McIntosh K, Novitsky V, Lee TH, Marlink R, Lagakos S, Essex M.
JAMA. 2006 Aug 16. 296(7):794-805. PMID: 16905785
Helminth infection suppresses T-cell immune response to HIV-DNA-based vaccine in mice.
Da'Dara AA, Lautsch N, Dudek T, Novitsky V, Lee TH, Essex M, Harn DA.
Vaccine. 2006 Jun 12. 24(24):5211-9. PMID: 16675073
Interactive association of proviral load and IFN-gamma-secreting T cell responses in HIV-1C infection.
Novitsky VA, Gilbert PB, Shea K, McLane MF, Rybak N, Klein I, Thior I, Ndung'u T, Lee TH, Essex ME.
Virology. 2006 May 25. 349(1):142-55. PMID: 16519915
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