Dr. De Gruttola's research activities focus on developments of statistical methods required for appropriate public health response to the AIDS epidemic. The aspects of the epidemic on which he has worked include transmission of the Human Immunodeficiency Virus (HIV), natural history of infection with HIV, and clinical research on AIDS therapies.
This work involves not only statistical methodology, but also public health surveillance systems, medical issues surrounding HIV infection, and concerns of communities most affected by the epidemic. The goals include forecasting future AIDS incidence, developing strategies for clinical research on HIV infection, and evaluating the public health impact of antiviral treatment. The statistical issues on which Dr. De Gruttola has been engaged include evaluating the degree to which the treatment response of markers of HIV infection constitute adequate evidence for clinical efficacy. He has also worked on projections of AIDS incidence using data from the New York City Health Department. A special focus of this work was estimation of the risk that children of HIV-infected mothers would develop AIDS in the first 10 years of life using data combined from a variety of sources.
Grant KJ, Parthasarathy A, Vasilkov V, Caswell-Midwinter B, Freitas ME, de Gruttola V, Polley DB, Liberman MC, Maison SF.
Sci Rep. 2022 06 23. 12(1):8929. PMID: 35739134
Aslam S, Liu J, Sigler R, Syed RR, Tu XM, Little SJ, De Gruttola V.
Transpl Infect Dis. 2022 Apr. 24(2):e13788. PMID: 34989104
Goyal R, Hotchkiss J, Schooley RT, De Gruttola V, Martin NK.
Clin Infect Dis. 2021 11 02. 73(9):1735-1741. PMID: 33462589
De Gruttola V, Goyal R, Martin NK.
Stat Med. 2021 05 20. 40(11):2511-2512. PMID: 33963584
Wu PZ, O'Malley JT, de Gruttola V, Liberman MC.
J Neurosci. 2021 05 19. 41(20):4439-4447. PMID: 33883202
Goyal R, De Gruttola V.
Stat Med. 2021 06 15. 40(13):3167-3180. PMID: 33811360
Mepani AM, Verhulst S, Hancock KE, Garrett M, Vasilkov V, Bennett K, de Gruttola V, Liberman MC, Maison SF.
J Neurophysiol. 2021 04 01. 125(4):1213-1222. PMID: 33656936
Samartsidis P, Martin NN, De Gruttola V, De Vocht F, Hutchinson S, Lok JJ, Puenpatom A, Wang R, Hickman M, De Angelis D.
Stat Commun Infect Dis. 2021 Jan 01. 13(1):20200005. PMID: 35880998
Hassan A, De Gruttola V, Hu YW, Sheng Z, Poortinga K, Wertheim JO.
Clin Infect Dis. 2020 12 03. 71(9):e384-e391. PMID: 32020172
Rennert L, Heo M, Litwin AH, De Gruttola V.
Res Sq. 2020 Nov 12. PMID: 33200125
The 22nd International AIDS Conference drew HIV/AIDS experts from around the world, including researchers from Harvard T.H. Chan School of Public Health, who presented new findings on topics including the risks of a new AIDS drug, “test-and-treat” campaigns…
June 17, 2014 — Victor De Gruttola, chair of the Department of Biostatistics and Henry Pickering Walcott Professor of Biostatistics at Harvard School of Public Health (HSPH), recently answered three questions about the role of biostatistics in public…
[Fall 2013 Centennial issue] The School’s fieldwork in HIV/AIDS, which has received support from the President’s Emergency Plan for AIDS Relief (PEPFAR), the National Institutes of Health, the Bill & Melinda Gates Foundation, NIH, and other private philanthropists,…
February 11, 2013 -- If you’re examining the impact of air pollution control efforts in Denver, how do you statistically account for the fact that air pollution travels east—and that pollution reduction in the western United States could…
May 11, 2012 Franziska Michor, associate professor of computational biology, received Harvard School of Public Health’s second annual Alice Hamilton Award on April 11, 2012 in recognition of her pathbreaking work applying evolutionary theory to cancer. The award,…
