Dr. De Gruttola's research activities focus on developments of statistical methods required for appropriate public health response to the AIDS epidemic. The aspects of the epidemic on which he has worked include transmission of the Human Immunodeficiency Virus (HIV), natural history of infection with HIV, and clinical research on AIDS therapies.
This work involves not only statistical methodology, but also public health surveillance systems, medical issues surrounding HIV infection, and concerns of communities most affected by the epidemic. The goals include forecasting future AIDS incidence, developing strategies for clinical research on HIV infection, and evaluating the public health impact of antiviral treatment. The statistical issues on which Dr. De Gruttola has been engaged include evaluating the degree to which the treatment response of markers of HIV infection constitute adequate evidence for clinical efficacy. He has also worked on projections of AIDS incidence using data from the New York City Health Department. A special focus of this work was estimation of the risk that children of HIV-infected mothers would develop AIDS in the first 10 years of life using data combined from a variety of sources.
Primary Neural Degeneration in Noise-Exposed Human Cochleas: Correlations with Outer Hair Cell Loss and Word-Discrimination Scores.
Wu PZ, O'Malley JT, de Gruttola V, Liberman MC.
J Neurosci. 2021 May 19. 41(20):4439-4447. PMID: 33883202
Investigation of patient-sharing networks using a Bayesian network model selection approach for congruence class models.
Goyal R, De Gruttola V.
Stat Med. 2021 06 15. 40(13):3167-3180. PMID: 33811360
Mepani AM, Verhulst S, Hancock KE, Garrett M, Vasilkov V, Bennett K, de Gruttola V, Liberman MC, Maison SF.
J Neurophysiol. 2021 04 01. 125(4):1213-1222. PMID: 33656936
Evaluation of SARS-CoV-2 transmission mitigation strategies on a university campus using an agent-based network model.
Goyal R, Hotchkiss J, Schooley RT, De Gruttola V, Martin NK.
Clin Infect Dis. 2021 Jan 19. PMID: 33462589
The Relationship Between the Human Immunodeficiency Virus-1 Transmission Network and the HIV Care Continuum in Los Angeles County.
Hassan A, De Gruttola V, Hu YW, Sheng Z, Poortinga K, Wertheim JO.
Clin Infect Dis. 2020 12 03. 71(9):e384-e391. PMID: 32020172
Accounting for Confounding by Time, Early Intervention Adoption, and Time-Varying Effect Modification in the Design and Analysis of Stepped-Wedge Designs: Application to a Proposed Study Design to Reduce Opioid-Related Mortality.
Rennert L, Heo M, Litwin AH, De Gruttola V.
Res Sq. 2020 Nov 12. PMID: 33200125
Montazeri H, Little S, Mozaffarilegha M, Beerenwinkel N, DeGruttola V.
Stat Appl Genet Mol Biol. 2020 Oct 21. PMID: 33085643
Wang R, DeGruttola V, Lei Q, Mayer KH, Redline S, Hazra A, Mora S, Willett WC, Ganmaa D, Manson JE.
Contemp Clin Trials. 2021 01. 100:106176. PMID: 33045402
Mindfulness-based stress reduction for HIV-associated neurocognitive disorder: Rationale and protocol for a randomized controlled trial in older adults.
Addington EL, Javandel S, De Gruttola V, Paul R, Milanini B, Ances BM, Moskowitz JT, Valcour V.
Contemp Clin Trials. 2020 11. 98:106150. PMID: 32942053
The 22nd International AIDS Conference drew HIV/AIDS experts from around the world, including researchers from Harvard T.H. Chan School of Public Health, who presented new findings on topics including the risks of a new AIDS drug, “test-and-treat” campaigns…
June 17, 2014 — Victor De Gruttola, chair of the Department of Biostatistics and Henry Pickering Walcott Professor of Biostatistics at Harvard School of Public Health (HSPH), recently answered three questions about the role of biostatistics in public…
[Fall 2013 Centennial issue] The School’s fieldwork in HIV/AIDS, which has received support from the President’s Emergency Plan for AIDS Relief (PEPFAR), the National Institutes of Health, the Bill & Melinda Gates Foundation, NIH, and other private philanthropists,…
February 11, 2013 -- If you’re examining the impact of air pollution control efforts in Denver, how do you statistically account for the fact that air pollution travels east—and that pollution reduction in the western United States could…
May 11, 2012 Franziska Michor, associate professor of computational biology, received Harvard School of Public Health’s second annual Alice Hamilton Award on April 11, 2012 in recognition of her pathbreaking work applying evolutionary theory to cancer. The award,…