Wendy Garrett
Professor

Wendy Garrett

Irene Heinz Given Professor of Immunology and Infectious Diseases

Immunology and Infectious Diseases

wgarrett@hsph.harvard.edu

Other Positions

Faculty Affiliate in the Department of Molecular Metabolism

Molecular Metabolism

Harvard T.H. Chan School of Public Health

Professor of Medicine

Medicine

Dana-Farber Cancer Institute


Overview

Wendy Garrett is the Irene Heinz Given Professor of Immunology and Infectious Diseases in the Departments of Immunology and Infectious Diseases and of Molecular Metabolism at the Harvard Chan School of Public Health, and also has a Professorship in the Departments of Medicine at Harvard Medical School. Dr. Garrett pursued an MD and PhD at Yale University. She completed a fellowship at the Dana-Farber Cancer Institute and postdoctoral training at Harvard University Medical School.

Dr. Garrett investigates host-microbiota interactions in health and disease. Her research team studies the interplay between the gastrointestinal immune system and the gut microbiota in health, inflammatory bowel disease (IBD) and colorectal cancer (CRC). The Garrett lab focuses on how the gut microbiota influence both innate and adaptive populations and the contribution of these cells to immune homeostasis and disease.

Dr. Garrett's team has identified specific species, pathways, and metabolites made by the microbiota that influence health and disease states. The lab also studies microbes and immune cells that are not only instrumental in potentiating carcinogenesis but are integral to intestinal homeostasis. The multi-faceted research approach includes meta'omics, microbiology, cellular immunology, biochemistry, cell biology, and cancer biology. The lab uses mouse models, human specimens, and primary and transformed mammalian cells and bacterial cells in their experiments in order to move facilely between large human data sets and in vivo and in vitro model systems with a core mission of determining basic biologic mechanism and applying the findings to precision medicine.

The Garrett lab is highly collaborative and works with many laboratories at institutions in the greater Boston area, in Harvard-affiliated hospitals and institutes, and at national and international research centers.

B.S./ M.S., , Combined Bachelor of Science & Master of Science
Yale University

Ph.D.
Yale University

M.D.
Yale University School of Medicine

Medical Oncology Fellowship
Dana-Farber Partners Cancer Care, Laboratory of Laurie H. Glimcher


Bibliography

Association of Fusobacterium nucleatum with Specific T-cell Subsets in the Colorectal Carcinoma Microenvironment.

Borowsky J, Haruki K, Lau MC, Dias Costa A, Väyrynen JP, Ugai T, Arima K, da Silva A, Felt KD, Zhao M, Gurjao C, Twombly TS, Fujiyoshi K, Väyrynen SA, Hamada T, Mima K, Bullman S, Harrison TA, Phipps AI, Peters U, Ng K, Meyerhardt JA, Song M, Giovannucci EL, Wu K, Zhang X, Freeman GJ, Huttenhower C, Garrett WS, Chan AT, Leggett BA, Whitehall VLJ, Walker N, Brown I, Bettington M, Nishihara R, Fuchs CS, Lennerz JK, Giannakis M, Nowak JA, Ogino S.

Clin Cancer Res. 2021 May 15. 27(10):2816-2826. PMID: 33632927


News

The future of cancer prevention (part 2)

In this episode, we speak to a scientist who is examining how our microbiome—the collection of trillions of microbes in and on our bodies—can affect the development of colon cancer.