Xin Wang

Tuberculosis treatment failure associated with evolution of antibiotic resilience.

Liu Q, Zhu J, Dulberger CL, Stanley S, Wilson S, Chung ES, Wang X, Culviner P, Liu YJ, Hicks ND, Babunovic GH, Giffen SR, Aldridge BB, Garner EC, Rubin EJ, Chao MC, Fortune SM.

Science. 2022 12 09. 378(6624):1111-1118. PMID: 36480634

Mycobacterium tuberculosis KasA as a drug target: Structure-based inhibitor design.

Rudraraju RS, Daher SS, Gallardo-Macias R, Wang X, Neiditch MB, Freundlich JS.

Front Cell Infect Microbiol. 2022. 12:1008213. PMID: 36189349

Rickettsia Aglow: A Fluorescence Assay and Machine Learning Model to Identify Inhibitors of Intracellular Infection.

Lemenze A, Mittal N, Perryman AL, Daher SS, Ekins S, Occi J, Ahn YM, Wang X, Russo R, Patel JS, Daugherty RM, Wood DO, Connell N, Freundlich JS.

ACS Infect Dis. 2022 07 08. 8(7):1280-1290. PMID: 35748568

Multiplexed Strain Phenotyping Defines Consequences of Genetic Diversity in Mycobacterium tuberculosis for Infection and Vaccination Outcomes.

Carey AF, Wang X, Cicchetti N, Spaulding CN, Liu Q, Hopkins F, Brown J, Sixsmith J, Sutiwisesak R, Behar SM, Ioerger TR, Fortune SM.

mSystems. 2022 06 28. 7(3):e0011022. PMID: 35430871

Bayesian Modeling and Intrabacterial Drug Metabolism Applied to Drug-Resistant Staphylococcus aureus.

Patel JS, Norambuena J, Al-Tameemi H, Ahn YM, Perryman AL, Wang X, Daher SS, Occi J, Russo R, Park S, Zimmerman M, Ho HP, Perlin DS, Dartois V, Ekins S, Kumar P, Connell N, Boyd JM, Freundlich JS.

ACS Infect Dis. 2021 08 13. 7(8):2508-2521. PMID: 34342426

Morphological profiling of tubercle bacilli identifies drug pathways of action.

Smith TC, Pullen KM, Olson MC, McNellis ME, Richardson I, Hu S, Larkins-Ford J, Wang X, Freundlich JS, Ando DM, Aldridge BB.

Proc Natl Acad Sci U S A. 2020 08 04. 117(31):18744-18753. PMID: 32680963

Machine Learning Platform to Discover Novel Growth Inhibitors of Neisseria gonorrhoeae.

Pereira JC, Daher SS, Zorn KM, Sherwood M, Russo R, Perryman AL, Wang X, Freundlich MJ, Ekins S, Freundlich JS.

Pharm Res. 2020 Jul 13. 37(7):141. PMID: 32661900

A Preclinical Candidate Targeting Mycobacterium tuberculosis KasA.

Inoyama D, Awasthi D, Capodagli GC, Tsotetsi K, Sukheja P, Zimmerman M, Li SG, Jadhav R, Russo R, Wang X, Grady C, Richmann T, Shrestha R, Li L, Ahn YM, Ho Liang HP, Mina M, Park S, Perlin DS, Connell N, Dartois V, Alland D, Neiditch MB, Kumar P, Freundlich JS.

Cell Chem Biol. 2020 05 21. 27(5):560-570.e10. PMID: 32197094

Antitubercular Triazines: Optimization and Intrabacterial Metabolism.

Wang X, Inoyama D, Russo R, Li SG, Jadhav R, Stratton TP, Mittal N, Bilotta JA, Singleton E, Kim T, Paget SD, Pottorf RS, Ahn YM, Davila-Pagan A, Kandasamy S, Grady C, Hussain S, Soteropoulos P, Zimmerman MD, Ho HP, Park S, Dartois V, Ekins S, Connell N, Kumar P, Freundlich JS.

Cell Chem Biol. 2020 02 20. 27(2):172-185.e11. PMID: 31711854

Intrabacterial Metabolism Obscures the Successful Prediction of an InhA Inhibitor of Mycobacterium tuberculosis.

Wang X, Perryman AL, Li SG, Paget SD, Stratton TP, Lemenze A, Olson AJ, Ekins S, Kumar P, Freundlich JS.

ACS Infect Dis. 2019 12 13. 5(12):2148-2163. PMID: 31625383