Yann Cormerais

Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin.

Byles V, Cormerais Y, Kalafut K, Barrera V, Hughes Hallett JE, Sui SH, Asara JM, Adams CM, Hoxhaj G, Ben-Sahra I, Manning BD.

Mol Metab. 2021 11. 53:101309. PMID: 34303878

A Cystine-Cysteine Intercellular Shuttle Prevents Ferroptosis in xCTKO Pancreatic Ductal Adenocarcinoma Cells.

Meira W, Daher B, Parks SK, Cormerais Y, Durivault J, Tambutte E, Pouyssegur J, Vucetic M.

Cancers (Basel). 2021 Mar 21. 13(6). PMID: 33801101

Amino Acid Transporters Are a Vital Focal Point in the Control of mTORC1 Signaling and Cancer.

Cormerais Y, Vucetic M, Parks SK, Pouyssegur J.

Int J Mol Sci. 2020 Dec 22. 22(1). PMID: 33375025

Targeting amino acids transporters (SLCs) to starve cancer cells to death.

Cormerais Y, Vucetic M, Pouysségur J.

Biochem Biophys Res Commun. 2019 12 17. 520(4):691-693. PMID: 31761081

Genetic Ablation of the Cystine Transporter xCT in PDAC Cells Inhibits mTORC1, Growth, Survival, and Tumor Formation via Nutrient and Oxidative Stresses.

Daher B, Parks SK, Durivault J, Cormerais Y, Baidarjad H, Tambutte E, Pouysségur J, Vucetic M.

Cancer Res. 2019 08 01. 79(15):3877-3890. PMID: 31175120

Inhibition of the amino-acid transporter LAT1 demonstrates anti-neoplastic activity in medulloblastoma.

Cormerais Y, Pagnuzzi-Boncompagni M, Schrötter S, Giuliano S, Tambutté E, Endou H, Wempe MF, Pagès G, Pouysségur J, Picco V.

J Cell Mol Med. 2019 04. 23(4):2711-2718. PMID: 30784173

Resistance to lysosomotropic drugs used to treat kidney and breast cancers involves autophagy and inflammation and converges in inducing CXCL5.

Giuliano S, Dufies M, Ndiaye PD, Viotti J, Borchiellini D, Parola J, Vial V, Cormerais Y, Ohanna M, Imbert V, Chamorey E, Rioux-Leclercq N, Savina A, Ferrero JM, Mograbi B, Pagès G.

Theranostics. 2019. 9(4):1181-1199. PMID: 30867824

The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5).

Cormerais Y, Massard PA, Vucetic M, Giuliano S, Tambutté E, Durivault J, Vial V, Endou H, Wempe MF, Parks SK, Pouyssegur J.

J Biol Chem. 2018 02 23. 293(8):2877-2887. PMID: 29326164

Dynamin inhibitors block activation of mTORC1 by amino acids independently of dynamin.

Persaud A, Cormerais Y, Pouyssegur J, Rotin D.

J Cell Sci. 2018 01 04. 131(1). PMID: 29150487

The Central Role of Amino Acids in Cancer Redox Homeostasis: Vulnerability Points of the Cancer Redox Code.

Vucetic M, Cormerais Y, Parks SK, Pouysségur J.

Front Oncol. 2017. 7:319. PMID: 29312889