Amino Acid Transporters Are a Vital Focal Point in the Control of mTORC1 Signaling and Cancer.
Cormerais Y, Vucetic M, Parks SK, Pouyssegur J.
Int J Mol Sci. 2020 Dec 22. 22(1). PMID: 33375025
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Yann Cormerais
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Targeting amino acids transporters (SLCs) to starve cancer cells to death.
Cormerais Y, Vucetic M, Pouysségur J.
Biochem Biophys Res Commun. 2019 12 17. 520(4):691-693. PMID: 31761081
Genetic Ablation of the Cystine Transporter xCT in PDAC Cells Inhibits mTORC1, Growth, Survival, and Tumor Formation via Nutrient and Oxidative Stresses.
Daher B, Parks SK, Durivault J, Cormerais Y, Baidarjad H, Tambutte E, Pouysségur J, Vucetic M.
Cancer Res. 2019 08 01. 79(15):3877-3890. PMID: 31175120
Inhibition of the amino-acid transporter LAT1 demonstrates anti-neoplastic activity in medulloblastoma.
Cormerais Y, Pagnuzzi-Boncompagni M, Schrötter S, Giuliano S, Tambutté E, Endou H, Wempe MF, Pagès G, Pouysségur J, Picco V.
J Cell Mol Med. 2019 04. 23(4):2711-2718. PMID: 30784173
Resistance to lysosomotropic drugs used to treat kidney and breast cancers involves autophagy and inflammation and converges in inducing CXCL5.
Giuliano S, Dufies M, Ndiaye PD, Viotti J, Borchiellini D, Parola J, Vial V, Cormerais Y, Ohanna M, Imbert V, Chamorey E, Rioux-Leclercq N, Savina A, Ferrero JM, Mograbi B, Pagès G.
Theranostics. 2019. 9(4):1181-1199. PMID: 30867824
The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5).
Cormerais Y, Massard PA, Vucetic M, Giuliano S, Tambutté E, Durivault J, Vial V, Endou H, Wempe MF, Parks SK, Pouyssegur J.
J Biol Chem. 2018 02 23. 293(8):2877-2887. PMID: 29326164
Dynamin inhibitors block activation of mTORC1 by amino acids independently of dynamin.
Persaud A, Cormerais Y, Pouyssegur J, Rotin D.
J Cell Sci. 2018 01 04. 131(1). PMID: 29150487
The Central Role of Amino Acids in Cancer Redox Homeostasis: Vulnerability Points of the Cancer Redox Code.
Vucetic M, Cormerais Y, Parks SK, Pouysségur J.
Front Oncol. 2017. 7:319. PMID: 29312889
The c-Jun N-terminal kinase prevents oxidative stress induced by UV and thermal stresses in corals and human cells.
Courtial L, Picco V, Grover R, Cormerais Y, Rottier C, Labbe A, Pagès G, Ferrier-Pagès C.
Sci Rep. 2017 04 04. 7:45713. PMID: 28374828
Hypoxia and cellular metabolism in tumour pathophysiology.
Parks SK, Cormerais Y, Pouysségur J.
J Physiol. 2017 04 15. 595(8):2439-2450. PMID: 28074546