Many target antigens from parasites, as well as the mechanisms that acquired immunity protects the host against protozoan infection have been defined. However, the means that innate immune responses mediate host resistance to infection with this class of pathogens remain to be elucidated. The lack of information in this area is a major drawback for the development of effective prophylactic vaccines or protocols of immune-based therapy to prevent or treat these diseases. Therefore, my main scientific interests are: (i) to dissect the mechanisms by which innate immunity mediate host resistance, preventing disease; as well as (ii) by targeting innate immune cells to develop vaccines that induce strong and long lasting T cell-mediated immunity and protection to infection with protozoan parasites.