Vincent Jaddoe 1214-016

Vincent Jaddoe

Adjunct Professor of Epidemiology

Department of Epidemiology

677 Huntington Avenue
Kresge Building, Room 902
Boston, MA 02115

Research

Dr. Jaddoe (1974) is Pediatrician and Professor of Pediatric Epidemiology. He is Principal Investigator of the Generation R Study, a population-based prospective cohort study among 10,000 pregnant women and their children in Rotterdam, The Netherlands (www.generationr.nl). His research is focused on 3 main themes: (1) Maternal and fetal health;(2) Fetal and infant programming of common childhood diseases; (3) Genetics and epigenetics of common childhood diseases. General aim of this research is to explore how genetic variants and environmental exposures lead to maternal gestational complications, fetal and childhood developmental adaptation mechanisms, and risk factors for common diseases. Specific interest is in the identification of early critical periods and mechanisms leading to risk factors for diseases in later life. Main diseases of interest include cardiovascular disease, type 2 diabetes, obesity and respiratory diseases. Genetic association studies are embedded in the Early Growth Genetics (EGG) Consortium and Early Growth & Longitudinal Epidemiology (EAGLE) Consortium, in which various birth cohorts (>30,000 subjects) combine their genome wide association studies efforts.

Additional Affiliations

The Generation R Study Group
Departments of Epidemiology and Pediatrics
Erasmus MC, University Medical Center, Rotterdam, the Netherlands
Phone: +31 10 7043405
Email: v.jaddoe@erasmusmc.nl

Selected Publications

  1. Freathy RM, Mook-Kanamori DO, Sovio U, Prokopenko I, Timpson NJ, Berry DJ, Warrington NM, Widen E, Hottenga JJ, Kaakinen M, Lange LA, Bradfield JP, Kerkhof M, Marsh JA, Magi R, Chen CM, Lyon HN, Kirin M, Adair LS, Aulchenko YS, Bennett AJ, Borja JB, Bouatia-Naji N, Charoen P, Coin LJ, Cousminer DL, de Geus EJ, Deloukas P, Elliott P, Evans DM, Froguel P, Genetic Investigation of ATC, Glaser B, Groves CJ, Hartikainen AL, Hassanali N, Hirschhorn JN, Hofman A, Holly JM, Hypponen E, Kanoni S, Knight BA, Laitinen J, Lindgren CM, Meta-Analyses of G, Insulin-related traits C, McArdle WL, O’Reilly PF, Pennell CE, Postma DS, Pouta A, Ramasamy A, Rayner NW, Ring SM, Rivadeneira F, Shields BM, Strachan DP, Surakka I, Taanila A, Tiesler C, Uitterlinden AG, van Duijn CM, Wellcome Trust Case Control C, Wijga AH, Willemsen G, Zhang H, Zhao J, Wilson JF, Steegers EA, Hattersley AT, Eriksson JG, Peltonen L, Mohlke KL, Grant SF, Hakonarson H, Koppelman GH, Dedoussis GV, Heinrich J, Gillman MW, Palmer LJ, Frayling TM, Boomsma DI, Davey Smith G, Power C, Jaddoe VW, Jarvelin MR, Early Growth Genetics C, McCarthy MI. Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nat Genet. 2010;42(5):430-5.
  2. Gaillard R, Bakker R, Steegers EAP, Hofman A, Jaddoe VW. Blood pressure tracking during pregnancy and the risk of gestational hypertensive disorders. The Generation R Study. Eur Heart J. 2011;32(24):3088-97.
  3. Gaillard R, Steegers EA, Tiemeier H, Hofman A, Jaddoe VW. Placental Vascular Dysfunction, Fetal and Childhood Growth and Cardiovascular Development. The Generation R Study. Circulation 2013. 2013;128(20):2202-10.
  4. Horikoshi M, Yaghootkar H, Mook-Kanamori DO, Sovio U, Taal HR, Hennig BJ, Bradfield JP, St. Pourcain B, Evans DM, Charoen P, Kaakinen M, Cousminer DL, Lehtimäki T, Kreiner-Møller E, Warrington NM, Bustamante M, Feenstra B, Berry DJ, Thiering E, Pfab T, Barton SJ, Shields BM, Kerkhof MJ, van Leeuwen EM, Fulford AJ, Kutalik Z, Hua Zhao J, den Hoed M, Mahajan A, Lindi V, Goh LK, Hottenga JJ, Wu Y, Raitakari O, Harder MN, Meirhaeghe A, Ntalla I, Salem RM, Jameson KM, Zhou K, Monies DM, Lagou V, Kirin M, Heikkinen J, Adair LS, Alkuraya FS, Al-Odaib A, Amouyel P, Andersson EA, Bennett AJ, Blakemore AI, Buxton JL, Dallongeville J, Das S, de Geus EJ, Estivill X, Flexeder C, Froguel P, Geller F, Godfrey KM, Gottrand F, Groves CJ, Hansen T, Hirschhorn JN, Hofman A, Hollegaard MV, Hougaard DM, Hyppönen E, Inskip HM, Isaacs A, Jørgensen T, Kanaka- Gantenbein C, Kemp JP, Kiess W, Kilpeläinen TO, Klopp NO, Knight BA, Kuzawa CW, McMahon G, Newnham JP, Niinikoski H, Oostra BA, Pedersen L, Postma DS, Ring SM, Rivadeneira F, Robertson NR, Sebert S, Simell O, Slowinski T, Tiesler CMT, Tönjes A, Vaag A, Viikari JS, Vink JM, Vissing NH, Wareham NJ, Willemsen GM, Witte DR, Zhang H, Zhao J, The Meta-Analyses of Glucose- and Insulin- related traits Consortium (MAGIC), Wilson JF, Stumvoll M, Prentice AM, Meyer BF, Pearson ER, Boreham CA, Cooper C, Gillman MW, Dedoussis G, Moreno LA, Pedersen O, Saarinen M, Mohlke KL, Boomsma DI, Saw SM, Lakka TA, Körner A, Loos RJ, Ong KK, Vollenweider P, van Duijn CM, Koppelman GH, Hattersley AT, Holloway JW, Hocher B, Heinrich J, Power C, Melbye M, Guxens M, Pennell CE, Bønnelykke K, Bisgaard H, Eriksson J, Widén E, Hakonarson H, Uitterlinden AG, Pouta A, Lawlor DA, Smith GD, Frayling TM, McCarthy MI, Grant SF, Jaddoe VW, Jarvelin MR, Timpson NJ, Prokopenko I, and Freathy RM. New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. Nat Genet 2013;45(1):76-82.
  5. Jaddoe VW, van Duijn CM, Franco OH, van der Heijden AJ, de Jongste JC, van der Lugt A, Mackenbach JP, Moll HA, Raat H, Rivadeneira F, Steegers EA, Tiemeier H, Uitterlinden AG, Verhulst FC, Hofman A. The Generation R Study: design and cohort update 2012. Eur J Epidemiol. 2012 27:739-56.
  6. Jaddoe VW, de Jonge LL, Franco OH, Hofman A, Steegers EA, Gaillard R. First-trimester fetal growth restriction and cardiovascular risk factors in in school-age children: a population-based cohort study. BMJ; 2014 ;348:g14. doi: 10.1136/bmj.g14.
  7. Jaddoe VW, Verburg BO, de Ridder MA, Hofman A, Mackenbach JP, Moll HA, Steegers EA, Witteman JC. Maternal smoking and fetal growth characteristics in different periods of pregnancy: the Generation R Study. Am J Epidemiol. 2007;165(10):1207-15.
  8. de Jonge LL, van Osch-Gevers L, Willemsen SP, Steegers EA, Hofman A, Helbing WA, Jaddoe VW. Growth, Obesity, and Cardiac Structures in Early Childhood: The Generation R Study. Hypertension 2011;57(5):934-40.
  9. Mook-Kanamori DO, Steegers EA, Eilers PH, Raat H, Hofman A, Jaddoe VW. Risk factors and outcomes associated with first-trimester fetal growth restriction. JAMA. 2010;303(6):527-34.
  10. Taal HR, St Pourcain B, Thiering E, Das S, Mook-Kanamori DO, Warrington NM, Kaakinen M, Kreiner- Moller E, Bradfield JP, Freathy RM, Geller F, Guxens M, Cousminer DL, Kerkhof M, Timpson NJ, Ikram MA, Beilin LJ, Bonnelykke K, Buxton JL, Charoen P, Chawes BL, Eriksson J, Evans DM, Hofman A, Kemp JP, Kim CE, Klopp N, Lahti J, Lye SJ, McMahon G, Mentch FD, Muller-Nurasyid M, O’Reilly PF, Prokopenko I, Rivadeneira F, Steegers EA, Sunyer J, Tiesler C, Yaghootkar H, Cohorts for H, Aging Research in Genetic Epidemiology C, Breteler MM, Decarli C, Debette S, Fornage M, Gudnason V, Launer LJ, van der Lugt A, Mosley TH, Jr., Seshadri S, Smith AV, Vernooij MW, Early G, Lifecourse Epidemiology C, Blakemore AI, Chiavacci RM, Feenstra B, Fernandez-Banet J, Grant SF, Hartikainen AL, van der Heijden AJ, Iniguez C, Lathrop M, McArdle WL, Molgaard A, Newnham JP, Palmer LJ, Palotie A, Pouta A, Ring SM, Sovio U, Standl M, Uitterlinden AG, Wichmann HE, Vissing NH, van Duijn CM, McCarthy MI, Koppelman GH, Estivill X, Hattersley AT, Melbye M, Bisgaard H, Pennell CE, Widen E, Hakonarson H, Smith GD, Heinrich J, Jarvelin MR, Jaddoe VW. Common variants at 12q15 and 12q24 are associated with infant head circumference. Nat Genet 2012;44: 532-8.