CBAR provides statistical leadership and expertise to collaborative research networks in HIV and other infectious diseases in the United States and internationally. This includes representing the Statistical and Data Analysis Center (SDAC) and the Data and Operations Center (DOC) for the following research networks:
The ACTG is an international cooperative clinical trials group dedicated to research in the treatment of HIV/AIDS, and the treatment and prevention of co-infections and other co-morbidities that affect HIV-infected people, notably tuberculosis and viral hepatitis. The ACTG is primarily funded by the National Institute of Allergy and Infectious Diseases (NIAID), with funding from other NIH Institutes including NCI and NIMH.
Selected Recent Publications
Corado KC, Chew KW, Giganti MJ, Mu Y, Fletcher CV, Currier JS, Daar ES, Wohl DA, Li JZ, Moser CB, Ritz J, Javan AC, Neytman G, Caskey M, Hughes MD, Smith DM, Eron JJ; ACTIV-2/A5401 Study Team. Safety, Efficacy, and Pharmacokinetics of Combination SARS-CoV-2 Neutralizing Monoclonal Antibodies BMS-986414 (C135-LS) and BMS-986413 (C144-LS) Administered Subcutaneously in Non-Hospitalized Persons with COVID-19 in a Phase 2 Trial. Pathog Immun. 2024 May 6;9(1):138-155. doi: 10.20411/pai.v9i1.660. PMID: 38746756; PMCID: PMC11093219. https://pubmed.ncbi.nlm.nih.gov/38746756/
Li JZ, Melberg M, Kittilson A, Abdel-Mohsen M, Li Y, Aga E, Bosch RJ, Wonderlich ER, Kinslow J, Giron LB, Di Germanio C, Pilkinton M, MacLaren L, Keefer M, Fox L, Barr L, Acosta E, Ananworanich J, Coombs R, Mellors J, Deeks S, Gandhi RT, Busch M, Landay A, Macatangay B, Smith DM; AIDS Clinical Trials Group A5345 Study Team. Predictors of HIV rebound differ by timing of antiretroviral therapy initiation. JCI Insight. 2024 Feb 8;9(3):e173864. doi: 10.1172/jci.insight.173864. PMID: 38329130; PMCID: PMC10967395. https://pubmed.ncbi.nlm.nih.gov/38329130/
Foldyna B, Mayrhofer T, Zanni MV, Lyass A, Barve R, Karady J, McCallum S, Burdo TH, Fitch KV, Paradis K, Fulda ES, Diggs MR, Bloomfield GS, Malvestutto CD, Fichtenbaum CJ, Aberg JA, Currier JS, Ribaudo HJ, Hoffmann U, Lu MT, Douglas PS, Grinspoon SK. Pericoronary Adipose Tissue Density, Inflammation, and Subclinical Coronary Artery Disease Among People With HIV in the REPRIEVE Cohort. Clin Infect Dis. 2023 Dec 15;77(12):1676-1686. doi: 10.1093/cid/ciad419. PMID: 37439633; PMCID: PMC10724469. https://pubmed.ncbi.nlm.nih.gov/37439633/
Gandhi RT, Bosch RJ, Mar H, Laird GM, Halvas EK, Hovind L, Collier AC, Riddler SA, Martin A, Ritter K, McMahon DK, Eron JJ, Cyktor JC, Mellors JW; AIDS Clinical Trials Group A5321 Team. Varied Patterns of Decay of Intact Human Immunodeficiency Virus Type 1 Proviruses Over 2 Decades of Antiretroviral Therapy. J Infect Dis. 2023 Jun 15;227(12):1376-1380. doi: 10.1093/infdis/jiad039. PMID: 36763044; PMCID: PMC10474937. https://pubmed.ncbi.nlm.nih.gov/36763044/
Sowah LA, Smeaton L, Brates I, Bhattacharya D, Linas B, Kreter B, Wagner-Cardoso S, Solomon S, Sulkowski M, Robbins GK. Perspectives on Adherence From the ACTG 5360 MINMON Trial: A Minimum Monitoring Approach With 12 Weeks of Sofosbuvir/Velpatasvir in Chronic Hepatitis C Treatment. Clin Infect Dis. 2023 Jun 8;76(11):1959-1968. doi: 10.1093/cid/ciad034. PMID: 36694361; PMCID: PMC10249990. https://pubmed.ncbi.nlm.nih.gov/36694361/
Agyemang N, Scarsi KK, Baker P, Smeaton LM, Podany AT, Olefsky M, Woolley E, Barr E, Pham M, Mawlana S, Supparatpinyo K, Gatechompol S, Jalil EM, Gadama L, Badal-Faesen S, Van Schalkwyk M, Kayama C, Belaunzaran-Zamudio PF, Godfrey C, Cohn SE, Mngqibisa R, Haas DW; AIDS Clinical Trials Group A5375 Study Team. Pharmacogenetic interactions of efavirenz or rifampin and isoniazid with levonorgestrel emergency contraception during treatment of HIV or tuberculosis. Pharmacogenet Genomics. 2023 Aug 1;33(6):126-135. doi: 10.1097/FPC.0000000000000501. Epub 2023 Jun 12. PMID: 37306344; PMCID: PMC10309098. https://pubmed.ncbi.nlm.nih.gov/37306344/
Krishnan S, Wu X, Kim S, McIntire K, Naini L, Hughes MD, Dawson R, Mave V, Gaikwad S, Sanchez J, Mendoza-Ticona A, Gonzales P, Comins K, Shenje J, Fontain SN, Omozoarhe A, Mohapi L, Lalloo UG, Garcia Ferreira AC, Mugah C, Harrington M, Shah NS, Hesseling AC, Churchyard G, Swindells S, Gupta A; AIDS Clinical Trials Group A5300/International Maternal Pediatric Adolescent AIDS Clinical Trials I2003 Protecting Households on Exposure to Newly Diagnosed Index Multidrug-resistant Tuberculosis Patients Feasibility Study Team* (Additional study group members are listed in the Acknowledgment section). 1-Year Incidence of Tuberculosis Infection and Disease Among Household Contacts of Rifampin- and Multidrug-Resistant Tuberculosis. Clin Infect Dis. 2023 Sep 18;77(6):892-900. doi: 10.1093/cid/ciad301. PMID: 37227925; PMCID: PMC10681643. https://pubmed.ncbi.nlm.nih.gov/37227925/
International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network
The IMPAACT Network is an international cooperative clinical trial groups dedicated to research in the treatment of children and adolescents with HIV/AIDS, its complications, and other infectious diseases that affect HIV-infected people, notably tuberculosis. It also has a major focus on research to prevent mother-to-child transmission of HIV. IMPAACT is primarily funded by the NIAID and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).
Selected Recent Publications
Dadabhai S, Chou VB, Pinilla M, Chinula L, Owor M, Violari A, Moodley D, Stranix-Chibanda L, Matubu TA, Chareka GT, Theron G, Kinikar AA, Mubiana-Mbewe M, Fairlie L, Bobat R, Mmbaga BT, Flynn PM, Taha TE, McCarthy KS, Browning R, Mofenson LM, Brummel SS, Fowler MG; IMPAACT PROMISE 1077BF/FF team.. Effects of preterm birth, maternal ART and breastfeeding on 24-month infant HIV-free survival in a randomized trial. AIDS. 2024 Mar 4. doi: 10.1097/QAD.0000000000003878. Epub ahead of print. PMID: 38427596. https://pubmed.ncbi.nlm.nih.gov/38427596/
Shivakoti R, Giganti MJ, Lederman MM, Ketchum R, Brummel S, Moisi D, Dadabhai S, Moodley D, Violari A, Chinula L, Owor M, Gupta A, Currier JS, Taha TE, Fowler MG; PROMISE study team. Systemic inflammation in pregnant women with HIV: relationship with HIV treatment regimen and preterm delivery. AIDS. 2024 Jul 1;38(8):1111-1119. doi: 10.1097/QAD.0000000000003877. Epub 2024 Mar 19. PMID: 38411599; PMCID: PMC11139235. https://pubmed.ncbi.nlm.nih.gov/38411599/
Persaud D, Bryson Y, Nelson BS, Tierney C, Cotton MF, Coletti A, Jao J, Spector SA, Mirochnick M, Capparelli EV, Costello D, Szewczyk J, Nicodimus N, Stranix-Chibanda L, Kekitiinwa AR, Korutaro V, Reding C, Carrington MN, Majji S, Yin DE, Jean-Philippe P, Chadwick EG. HIV-1 reservoir size after neonatal antiretroviral therapy and the potential to evaluate antiretroviral-therapy-free remission (IMPAACT P1115): a phase 1/2 proof-of-concept study. Lancet HIV. 2024 Jan;11(1):e20-e30. doi: 10.1016/S2352-3018(23)00236-9. Epub 2023 Dec 4. PMID: 38061376; PMCID: PMC11094801. https://pubmed.ncbi.nlm.nih.gov/38061376/
Van Schalkwyk M, Bekker A, Decloedt E, Wang J, Theron GB, Cotton MF, Eke AC, Cressey TR, Shapiro DE, Bacon K, Knowles K, George K, Browning R, Chakhtoura N, Rungruengthanakit K, Wiesner L, Capparelli EV, Stek AM, Mirochnick M, Best BM; IMPAACT P1026s Protocol Team. Pharmacokinetics and safety of first-line tuberculosis drugs rifampin, isoniazid, ethambutol, and pyrazinamide during pregnancy and postpartum: results from IMPAACT P1026s. Antimicrob Agents Chemother. 2023 Nov 15;67(11):e0073723. doi: 10.1128/aac.00737-23. Epub 2023 Oct 26. PMID: 37882552; PMCID: PMC10648924. https://pubmed.ncbi.nlm.nih.gov/37882552/
Gupta A, Singh P, Aaron L, Montepiedra G, Chipato T, Stranix-Chibanda L, Chanaiwa V, Vhembo T, Mutambanengwe M, Masheto G, Raesi M, Bradford S, Golner A, Costello D, Kulkarni V, Shayo A, Kabugho E, Jean-Phillippe P, Chakhtoura N, Sterling TR, Theron G, Weinberg A; IMPAACT P1078 TB APPRISE Study Team. Timing of maternal isoniazid preventive therapy on tuberculosis infection among infants exposed to HIV in low-income and middle-income settings: a secondary analysis of the TB APPRISE trial. Lancet Child Adolesc Health. 2023 Oct;7(10):708-717. doi: 10.1016/S2352-4642(23)00174-8. Epub 2023 Aug 24. PMID: 37634517; PMCID: PMC10883460. https://pubmed.ncbi.nlm.nih.gov/37634517/
Pediatric HIV/AIDS Cohort Study (PHACS)
The Pediatric HIV/AIDS Cohort Study (PHACS) network conducts longitudinal cohort studies investigating the long-term effects of HIV and antiretroviral (ARV) medications in infants, children, adolescents, and young adults (YA) living with perinatal HIV (PHIV) or born HIV-negative to mothers living with HIV. The PHACS network follows participants at 21 clinical sites across the U.S., including Puerto Rico. It is primarily funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), with co-funding from NIDCR, NIAID, NINDS, NIDCD, NIMH, NIDA, NCI, NIAAA, NHLBI, and the Office of the Director. See the PHACS network website for more detail: www.phacsstudy.org
Selected Recent Publications
Berhie S, Kacanek D, Lee J, Jao J, Powis K, Salomon L, Siddiqui D, Yee LM; Pediatric HIV/AIDS Cohort Study. Routine Vaccination During Pregnancy Among People Living With HIV in the United States. JAMA Netw Open. 2024 May 1;7(5):e249531. doi: 10.1001/jamanetworkopen.2024.9531. PMID: 38696165; PMCID: PMC11066702. https://pubmed.ncbi.nlm.nih.gov/38696165/
Fisher SA, Jao JK, Yee LM, Serghides L, Chadwick EG, Jacobson DL. Association of Fatty Acid Signatures with HIV Viremia in Pregnancy. AIDS Res Hum Retroviruses. 2024 Apr;40(4):257-267. doi: 10.1089/AID.2023.0040. Epub 2023 Oct 30. PMID: 37772708; PMCID: PMC11040191. https://pubmed.ncbi.nlm.nih.gov/37772708/
Dirajlal-Fargo S, Jacobson DL, Yu W, Mirza A, Geffner ME, Mccomsey GA, Jao J; Pediatric HIV/AIDS Cohort Study (PHACS). Longitudinal changes in body fat and metabolic complications in young people with perinatally acquired HIV. HIV Med. 2024 Feb;25(2):233-244. doi: 10.1111/hiv.13566. Epub 2023 Oct 16. PMID: 37845017; PMCID: PMC10872855. https://pubmed.ncbi.nlm.nih.gov/38696165/
Caceres GA, Scambray KA, Malee K, Smith R, Williams PL, Wang L, Jenkins LM; Pediatric HIV/AIDS Cohort Study. Relationship between brain structural network integrity and emotional symptoms in youth with perinatally-acquired HIV. Brain Behav Immun. 2024 Feb;116:101-113. doi: 10.1016/j.bbi.2023.11.026. Epub 2023 Dec 2. PMID: 38043871; PMCID: PMC10842701. https://pubmed.ncbi.nlm.nih.gov/38043871/
Davtyan M, Kacanek D, Lee J, Berman C, Chadwick EG, Smith R, Salomon L, Frederick T; Pediatric HIV/AIDS Cohort Study. Factors associated with internalized HIV-related stigma among biological mothers living with HIV enrolled in a US cohort study. AIDS Care. 2024 Feb;36(2):220-226. doi: 10.1080/09540121.2023.2263680. Epub 2024 Jan 30. PMID: 37757482; PMCID: PMC10842531. https://pubmed.ncbi.nlm.nih.gov/37757482/
Tassiopoulos K, Huo Y, Kacanek D, Malee K, Nichols S, Mellins CA, Kohlhoff S, Van Dyke RB; Pediatric HIV/AIDS Cohort Study. Association of Perceived Social Support with Viral Suppression Among Young Adults with Perinatally-Acquired HIV in the US-based Pediatric HIV/AIDS Cohort Study (PHACS). Clin Epidemiol. 2023 May 9;15:601-611. doi: 10.2147/CLEP.S403570. PMID: 37193342; PMCID: PMC10182767. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182767/
Other research projects include:
The Biostatistical Core for the Harvard University Center for AIDS Research (CFAR)
The Botswana Harvard AIDS Institute Partnership (BHP)
Data Coordinating Center for the Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE)
