Collaborative Research Networks

CBAR provides statistical leadership and expertise to collaborative research networks in HIV and other infectious diseases in the United States and internationally. This includes representing the Statistical and Data Analysis Center (SDAC) and the Data and Operations Center (DOC) for the following research networks:

Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections – ACTG (formerly known as the AIDS Clinical Trials Group)

ACTG LogoThe ACTG is an international cooperative clinical trials group dedicated to research in the treatment of HIV/AIDS, and the treatment and prevention of co-infections and other co-morbidities that affect HIV-infected people, notably tuberculosis and viral hepatitis. The ACTG is primarily funded by the National Institute of Allergy and Infectious Diseases (NIAID), with funding from other NIH Institutes including NCI and NIMH.

Selected Recent Publications

Scarsi KK, Smeaton LM, Podany AT, Olefsky M, Woolley E, Barr E, Pham M, Mawlana S, Supparatpinyo K, Gatechompol S, Jalil EM, Gadama L, Badal-Faesen S, Belaunzaran-Zamudio PF, Godfrey C, Cohn SE, Mngqibisa R; ACTG A5375 Study Team. Pharmacokinetics of dose-adjusted levonorgestrel emergency contraception combined with efavirenz-based antiretroviral therapy or rifampicin-containing tuberculosis regimens. Contraception. 2023 May;121:109951. doi: 10.1016/j.contraception.2023.109951. Epub 2023 Jan 12. PMID: 36641094; PMCID: PMC10187685.

Kim S, Hesseling AC, Wu X, Hughes MD, Shah NS, Gaikwad S, Kumarasamy N, Mitchell E, Leon M, Gonzales P, Badal-Faesen S, Lourens M, Nerette S, Shenje J, de Koke P, Nedsuwan S, Mohapi L, Chakalisa UA, Mngqbisa R, Escada RO, Ouma S, Heckman B, N Naini L, Gupta A, Swindells S, Churchyard G, on behalf of the ACTG A5300/IMPAACT 2003 PHOENIx Feasibility Study Team. Factors associated with prevalent Mycobacterium tuberculosis infection and disease among adolescents and adults exposed to rifampin-resistant tuberculosis in the household. PLoS One. 2023 Mar 17;18(3):e0283290. doi: 10.1371/journal.pone.0283290. PMID: 36930628; PMCID: PMC10022776.

Wyles DL, Kang M, Matining RM, Murphy RL, Peters MG. Adverse Impact of HIV-1 on Long-term Outcomes Following HCV DAA Treatment: Final Results of ACTG A5320, the Viral Hepatitis C Infection Long-term Cohort Study (VHICS). Open Forum Infect Dis. 2023 Mar 6:10(3):ofad115. doi: /ofid/ofad115. PubMed PMID: 37008564; PubMed Central PMCID: PMC10061557.

Li Y, Harrison LJ, Chew KW, Currier JS, Wohl DA, Daar ES, Evering TH, Wu R, Giganti M, Ritz J, Javan AC, Coombs RW, Moser C, Hughes MD, Eron JJ, Smith DM, Li JZ. Nasal and Plasma Severe Acute Respiratory Syndrome Coronavirus 2 RNA Levels Are Associated With Timing of Symptom Resolution in the ACTIV-2 Trial of Nonhospitalized Adults With Coronavirus Disease 2019. Clin Infect Dis. 2023 Feb 18;76(4):734-737. doi: 10.1093/cid/ciac818. PubMed PMID: 36210483; PubMed Central PMCID: PMC9619579.

 Manuzak JA, Granche J, Tassiopoulos K, Rower JE, Knox JR, Williams DW, Ellis RJ, Goodkin K, Sharma A, Erlandson KM; AIDS Clinical Trials Group (ACTG) A5322 Study Team. Cannabis Use Is Associated With Decreased Antiretroviral Therapy Adherence Among Older Adults With HIV. Open Forum Infect Dis. 2023 Jan 5;10(1):ofac699. doi: 10.1093/ofid/ofac699. PubMed PMID: 36726540; PubMed Central PMCID: PMC9879711.

 Smith DM, Li JZ, Moser C, Yeh E, Currier JS, Chew KW, Hughes MD; ACTIV-2/A5401 Study Team. Recurrence of Symptoms Following a 2-Day Symptom Free Period in Patients with COVID-19. JAMA Netw Open. 2022 Oct 3;5(10):e2238867. doi: 10.1001/jamanetworkopen. 2022.38867. PubMed PMID: 36301549; PubMed Central PMCID: PMC9614575.

International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network

IMPAACTThe IMPAACT Network is an international cooperative clinical trial groups dedicated to research in the treatment of children and adolescents with HIV/AIDS, its complications, and other infectious diseases that affect HIV-infected people, notably tuberculosis.  It also has a major focus on research to prevent mother-to-child transmission of HIV. IMPAACT is primarily funded by the NIAID and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).

Selected Recent Publications

Hsu J, Van Besien K, Glesby MJ, Pahwa S, Coletti A, Warshaw MG, Petz L, Moore TB, Chen YH, Pallikkuth S, Dhummakupt A, Cortado  R, Golner A, Bone F, Baldo M, Riches M, Mellors JW, Tobin NH, Browning R, Persaud D, Bryson Y; International Maternal Pediatric Adolescent AIDS Clinical Trials Network (IMPAACT) P1107 Team. HIV-1 remission and possible cure in a woman after haplo-cord blood transplant. Cell. 2023 Mar 16; 186(6):1115-1126.e8. doi: 10.1016/j.cell.2023.02.030. PMID: 36931242.

Nelson BS, Tierney C, Persaud D, Jao J, Cotton MF, Bryson Y, Coletti A, Ruel TD, Spector SA, Reding C, Bacon K, Costello D, Perlowski C, Santos Cruz ML, Kosgei J, Majji S, Yin DE, Jean-Philippe P, Chadwick EG; IMPAACT P1115 Team. Infants Receiving Very Early Antiretroviral Therapy Have High CD4 Counts in the First Year of Life. Clin Infect Dis. 2023 Feb 8;76(3):e744-e747. doi: 10.1093/cid/ciac695. PMID: 36031390; PubMed Central PMCID: PMC10169385.

Cunningham CK, Karron RA, Muresan P, Kelly MS, McFarland EJ, Perlowski C, Libous J, Oliva J, Jean-Philippe P, Moye J, Schappell E, Barr E, Rexroad V, Johnston B, Chadwick EG, Cielo M, Paul M, Deville JG, Aziz M, Yang L, Luongo C, Collins PL, Buchholz UJ; International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) 2018 Study Team. Evaluation of Recombinant Live-Attenuated Respiratory Syncytial Virus (RSV) Vaccines RSV/ΔNS2/Δ1313/I1314L and RSV/276 in RSV-Seronegative Children. J Infect Dis. 2022 Dec 13;226(12):2069-2078. doi: 10.1093/infdis/jiac253. PMID: 35732186; PubMed Central PMCID: PMC10205613.

Rouzier V, Murrill M, Kim S, Naini L, Shenje J, Mitchell E, Raesi M, Lourens M, Mendoza A, Conradie F, Suryavanshi N, Hughes M, Shah S, Churchyard G, Swindells S, Hesseling A, Gupta A. Caregiver willingness to give TPT to children living with drug-resistant TB patients. Int J Tuberc Lung Dis. 2022 Oct 1;26(10):949-955. doi: 10.5588/ijtld.21.0760. PMID: 36163664; PMCID: PMC9524515.

Brown LK, Baltrusaitis K, Kennard BD, Emslie GJ, Chernoff M, Buisson S, Lypen K, Whiteley LB, Traite S, Krotje C, Knowles K, Townley E, Deville J, Wilkins M, Reirden D, Paul M, Beneri C, Shapiro DE. Forty-eight Week Outcomes of a Site-Randomized Trial of Combined Cognitive Behavioral Therapy and Medication Management Algorithm for Treatment of Depression Among Youth with HIV in the United States. J Acquir Immune Defic Syndr. 2022 July 15. PubMed PMID: 35839439; PubMed Central PMCID: PMC9561232; DOI: 10.1097/QAI.0000000000003058.

Kim S, Wu X, Hughes MD, Upton C, Narunsky K, Mendoza-Ticona A, Khajenoori S, Gonzales, P, Badal-Faesen S, Shenje J, Omoz-Oarhe A, Rouzier V, Garcia-Prats AJ, Demers AM, Naini L, Smith E, Churchyard G, Swindells S, Shah NS, Gupta A, Hesseling AC. High Prevalence of Tuberculosis Infection and Disease in Child Household Contacts of Adults With Rifampinresistant Tuberculosis. Pediatr Infect Dis J. 2022 May 1;41(5):e194-e202. PubMed PMID: 35239624; PubMed Central PMCID: PMC9007870; DOI:10.1097/INF.0000000000003505.

Pediatric HIV/AIDS Cohort Study (PHACS)

PHACSThe Pediatric HIV/AIDS Cohort Study (PHACS) network conducts longitudinal cohort studies investigating the long-term effects of HIV and antiretroviral (ARV) medications in infants, children, adolescents, and young adults (YA) living with perinatal HIV (PHIV) or born HIV-negative to mothers living with HIV. The PHACS network follows participants at 21 clinical sites across the U.S., including Puerto Rico. It is primarily funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), with co-funding from NIDCR, NIAID, NINDS, NIDCD, NIMH, NIDA, NCI, NIAAA, NHLBI, and the Office of the Director.  See the PHACS network website for more detail:

Selected Recent Publications

Jao J, Kacanek D, Broadwell C, Jacobson DL, Chadwick EG, Williams PL, Powis KM, Haddad LB, and Yee L for the Pediatric HIV/AIDS Cohort Study. Gestational weight gain in persons living with HIV in the United States: results from the PHACS SMARTT study. AIDS. 2023 May 1; ;37(6):883-893. doi: 10.1097/QAD.0000000000003454. Epub 2022 Dec 2. PMCID: PMC10079618

Shiau S, Jacobson DL, Huo Y, Kacanek D, Yee LM, Williams DB, Haddad LB, Serghides L, Powis K, Sperling RS, Williams PL, Jao J, for the Pediatric HIV/AIDS Cohort Study (PHACS). Unique profile of inflammation and immune activation in pregnant people with HIV in the United States. J Infect Dis. 2023 Mar 1; Mar 1;227(5):720-730. PMID: 36592383 PMCID: PMC10152501

Yao TJ, Malee K, Zhang J, Smith R, Redmond S, Rice ML, Frederick T, Torre P, Mellins CA, Hoffman HJ, Williams PL; Pediatric HIV/AIDS Cohort Study. In Utero Antiretroviral Exposure and Risk of Neurodevelopmental Problems in HIV-Exposed Uninfected 5-Year-Old Children. AIDS Patient Care STDS. 2023 Mar;37(3):119-130. Epub. PMID: 36827595 PMCID: PMC10081721

Lemon TL, Tassiopoulos K, Tsai AC, Cantos K, Escudero D, Quinn MK, Kacanek D, Berman C, Salomon L, Nichols S, Chadwick EG, Seage G III, Williams PL, for the Pediatric HIV/AIDS Cohort Study. Health insurance coverage, clinical outcomes, and health-related quality of life among youth born to women living with HIV. J Acquir Immune Defic Syndr. 2023 Jan 1;92(1):6-16. PMCID: PMC9742193

Yee LM, Kacanek D, Brightwell C, Haddad LB, Jao J, Powis KM, Yao TJ, Barr E, Broadwell C, Siminski S, Seage G, for the Pediatric HIV/AIDS Cohort Study (PHACS). Opioid, alcohol, and marijuana use among pregnant and postpartum individuals living with HIV in the United States. JAMA Netw Open 2021 Dec 1; 4(12):e2137162. PMCID: PMC8642784.

Other research projects include:

CFARThe Biostatistical Core for the Harvard University Center for AIDS Research (CFAR)

BHPThe Botswana Harvard AIDS Institute Partnership (BHP)

REPRIEVEData Coordinating Center for the Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE)