665 Huntington Avenue
Building I Room 411
Boston, Massachusetts 02115
Phone: 617.432.4925

Other Affiliations

Assistant Professor of Medicine at Harvard Medical School


Dr. Lange’s research interests are at the intersection of biostatistical methodology, numerical analysis and computer science. Formally trained in all 3 areas, Dr. Lange headed the analysis of the first genome-wide association study for complex diseases, the longitudinal analysis of BMI in the Framingham Heart Study. To address the challenges of this first wave of “big data” in genetics, Dr. Lange’s group developed statistical methodology to maximize power in such studies that minimize the effects of the multiple testing problem in GWAS and developed massively parallel software implementations for the analysis that also efficiently scale with the study size (PBAT software package). Dr. Lange’s group then successfully commercialized
the package in collaboration with GoldenHelix.

Currently, Dr. Lange groups focuses on the statistical and computational challenges posed by whole-genome sequencing studies, e.g. powerful analysis methodology, clustering approaches of the genome, approaches to permutation testing, storage algorithm, etc.

Dr. Lange is also involved in collaborative research in Asthma Genetics, COPD Genetics and Alzheimer Genetics.


Ph.D., 2000, University of Reading, United Kingdom