MIPS Seminar: A human asthma exacerbation model identifies novel transcriptional programs and pathogenic cell circuits in the lower airway mucosa specific to al

Jehan Alladina, MD, Instructor in Medicine, Pulmonary, Massachusetts General Hospital

Understand the use of bronchoscopic segmental allergen challenge as a human model of asthma exacerbation; Identify cellular and molecular pathways in the airway mucosa that distinguish allergic asthma from allergy alone; Identify potential targets to achieve disease remission, including pathways that amplify type 2 airway inflammation and link inflammation to structural remodeling.