Miguel Martinez-Gonzalez

Adjunct Professor of Nutrition

Department of Nutrition


Dr. Miguel A. Martínez-Gonzalez’s major research interests include:

  • Effects of the Mediterranean food pattern on health
  • Nutritional epidemiology of cardiovascular disease, type 2 diabetes, obesity, metabolic syndrome and major depression
  • Metabolomic profiling in epidemiologic and interventional studies of type 2 diabetes and cardiovascular disease
  • Design and development of lifestyle/diet intervention trials for the prevention of cardiovascular disease.

Dr. Martinez-Gonzalez is a chronic disease epidemiologist and the leader of several cohorts and trials conducted in Spain.

Since its inception (1999) he has been the Principal Investigator (PI) of the SUN project (prospective dynamic cohort study with >22,500 participants and mean follow-up of >9 years), patterned after the models of the Nurses Health Study.

Dr. Martinez-Gonzalez was the PI of the PREDIMED trial (www.predimed.es) at the University of Navarra (the vanguard centre of PREDIMED) and he was the coordinator of the PREDIMED Research Network funded by the Spanish Government (Instituto de Salud Carlos III, RD 06/0045). PREDIMED was the first randomized primary prevention trial of CVD through a dietary intervention based on a dietary pattern approach (published in 2013).

Dr. Martinez-Gonzalez is also the PI of the European Research Council Advanced Research Grant to fund the PREDIMEDPLUS trial, an on-going cardiovascular primary prevention trial with >6,800 randomized participants. The PREDIMED-PLUS aim is to assess the cardiovascular effects of an energy-restricted Mediterranean diet with physical activity and weight loss on-going in 23 centres. His PREDIMEDPLUS-NAVARRA centre was also the vanguard centre for this large trial.

Selected publications (full list)

  1. Martínez-González MA, Corella D, Salas-Salvadó J, Ros E, Covas MI, Fiol M, et al; for the PREDIMED Study Investigators. Cohort Profile: design and methods of the PREDIMED study. Int J Epidemiol 2012;41:377-85
  2. Estruch R, Ros E, Salas-Salvadó J, Covas MI, Corella D, Arós F, Gómez-Gracia E, Ruiz-Gutiérrez V, Fiol M, Lapetra J, Lamuela-Raventos RM, Serra-Majem L, Pintó X, Basora J, Muñoz MA, Sorlí JV, Martínez JA, Martínez-González MA. Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med 2013;368:1279-90.
  3. Martínez-González MA, Toledo E, Arós F, Fiol M, Corella D, Salas-Salvadó J, Ros E, Covas MI, Fernández-Crehuet J, Lapetra J, Muñoz MA, Fitó M, Serra-Majem L, Pintó X, Lamuela-Raventós RM, Sorlí JV, Babio N, Buil-Cosiales P, Ruiz-Gutierrez V, Estruch R, Alonso A; PREDIMED Investigators. Extravirgin Olive Oil Consumption Reduces Risk of Atrial Fibrillation: The PREDIMED (Prevención con Dieta Mediterránea) Trial. Circulation 2014;130:18-26.
  4. Martínez-González MA, Bes-Rastrollo M. Dietary patterns, Mediterranean diet, and cardiovascular disease. Curr Opin Lipidol 2014;25:20-6.
  5. Martínez-González MA, Guillén-Grima F, De Irala J, Ruíz-Canela M, Bes-Rastrollo M, et al. The Mediterranean diet is associated with a reduction in premature mortality among middle-aged adults. J Nutr 2012;142:1672-8.
  6. Martínez-González MA, García-López M, Bes-Rastrollo M, Toledo E, Martínez-Lapiscina EH, et al. Mediterranean diet and the incidence of cardiovascular disease: a Spanish cohort. Nutr Metab Cardiov Dis 2011;21:237-44.
  7. Toledo E, Salas-Salvadó J, Donat-Vargas C, Buil-Cosiales P, Estruch R, Ros E, Corella D, Fitó M, Hu FB, Arós F, Gómez-Gracia E, Romaguera D, Ortega-Calvo M, Serra-Majem L, Pintó X, Schröder H, Basora J, Sorlí JV, Bulló M, Serra-Mir M, Martínez-González MA. Mediterranean Diet and Invasive Breast Cancer Risk Among Women at High Cardiovascular Risk in the PREDIMED Trial: A Randomized Clinical Trial. JAMA Intern Med 2015;175:1752-60.
  8. Martínez-González MA, Salas-Salvadó J, Estruch R, Corella D, Fitó M, et al. Benefits of the Mediterranean Diet: Insights From the PREDIMED Study. Prog Cardiovasc Dis 2015;58:50-60.
  9. Martínez-González MA, Martínez JA, Hu FB, Gibney MJ, Kearney J. Physical inactivity, sedentary lifestyle and obesity in the European Union. Int J Obes Relat Metab Disord 1999;23:1192-201.
  10. Martínez-González MÁ, Ruiz-Canela M, Hruby A, Liang L, Trichopoulou A, Hu FB. Intervention Trials with the Mediterranean Diet in Cardiovascular Prevention: Understanding Potential Mechanisms through Metabolomic Profiling. J Nutr. 2016 Mar 9. pii: jn219147.
  11. Wang DD, Toledo E, Hruby A, Rosner BA, Willett WC, Sun Q, Razquin C, Zheng Y,
    Ruiz-Canela M, Guasch-Ferré M, Corella D, Gómez-Gracia E, Fiol M, Estruch R, Ros
    E, Lapetra J, Fito M, Aros F, Serra-Majem L, Lee CH, Clish CB, Liang L,
    Salas-Salvadó J, Martínez-González MA, Hu FB. Plasma Ceramides, Mediterranean
    Diet, and Incident Cardiovascular Disease in the PREDIMED Trial (Prevención con
    Dieta Mediterránea). Circulation 2017;135:2028-2040.