Alec Walker

Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain.

Marsh SE, Walker AJ, Kamath T, Dissing-Olesen L, Hammond TR, de Soysa TY, Young AMH, Murphy S, Abdulraouf A, Nadaf N, Dufort C, Walker AC, Lucca LE, Kozareva V, Vanderburg C, Hong S, Bulstrode H, Hutchinson PJ, Gaffney DJ, Hafler DA, Franklin RJM, Macosko EZ, Stevens B.

Nat Neurosci. 2022 03. 25(3):306-316. PMID: 35260865

A RIPK1-regulated inflammatory microglial state in amyotrophic lateral sclerosis.

Mifflin L, Hu Z, Dufort C, Hession CC, Walker AJ, Niu K, Zhu H, Liu N, Liu JS, Levin JZ, Stevens B, Yuan J, Zou C.

Proc Natl Acad Sci U S A. 2021 03 30. 118(13). PMID: 33766915

Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes.

Hammond TR, Dufort C, Dissing-Olesen L, Giera S, Young A, Wysoker A, Walker AJ, Gergits F, Segel M, Nemesh J, Marsh SE, Saunders A, Macosko E, Ginhoux F, Chen J, Franklin RJM, Piao X, McCarroll SA, Stevens B.

Immunity. 2019 01 15. 50(1):253-271.e6. PMID: 30471926

CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development.

Lehrman EK, Wilton DK, Litvina EY, Welsh CA, Chang ST, Frouin A, Walker AJ, Heller MD, Umemori H, Chen C, Stevens B.

Neuron. 2018 10 10. 100(1):120-134.e6. PMID: 30308165

Removal of ineligible outcome cases reduces confounding.

Walker AM, Schneeweiss S, DerSarkissian M, Duh MS.

Clin Epidemiol. 2018. 10:575-579. PMID: 29872346

Reuse of data sources to evaluate drug safety signals: When is it appropriate?

Wang SV, Kulldorff M, Glynn RJ, Gagne JJ, Pottegård A, Rothman KJ, Schneeweiss S, Walker AM.

Pharmacoepidemiol Drug Saf. 2018 06. 27(6):567-569. PMID: 29701279

Sequential surveillance for drug safety in a regulatory environment.

Martin D, Gagne JJ, Gruber S, Izem R, Nelson JC, Nguyen MD, Ouellet-Hellstrom R, Schneeweiss S, Toh S, Walker AM.

Pharmacoepidemiol Drug Saf. 2018 07. 27(7):707-712. PMID: 29504168

Possible Opioid Shopping and its Correlates.

Walker AM, Weatherby LB, Cepeda MS, Bradford D, Yuan Y.

Clin J Pain. 2017 Nov. 33(11):976-982. PMID: 28145912

For drug-induced carcinogenesis, the observations are the hypothesis: Invited editorial for the Mini-Symposium on Cancer Pharmacoepidemiology.

Walker AM.

Ann Epidemiol. 2016 11. 26(11):749-750. PMID: 27637749

Design and analysis choices for safety surveillance evaluations need to be tuned to the specifics of the hypothesized drug-outcome association.

Gruber S, Chakravarty A, Heckbert SR, Levenson M, Martin D, Nelson JC, Psaty BM, Pinheiro S, Reich CG, Toh S, Walker AM.

Pharmacoepidemiol Drug Saf. 2016 09. 25(9):973-81. PMID: 27418432